Variation in Post-Transplant Cancer Incidence among Italian Kidney Transplant Recipients over a 25-Year Period.

Italy cohort study immunosuppression kidney transplant trend virus-related malignancy

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
20 Feb 2023
Historique:
received: 11 01 2023
revised: 08 02 2023
accepted: 17 02 2023
entrez: 25 2 2023
pubmed: 26 2 2023
medline: 26 2 2023
Statut: epublish

Résumé

This cohort study examined 25-year variations in cancer incidence among 11,418 Italian recipients of kidney transplantation (KT) from 17 Italian centers. Cancer incidence was examined over three periods (1997-2004; 2005-2012; and 2013-2021) by internal (Incidence rate ratio-IRR) and external (standardized incidence ratios-SIR) comparisons. Poisson regression was used to assess trends. Overall, 1646 post-transplant cancers were diagnosed, with incidence rates/1000 person-years ranging from 15.5 in 1997-2004 to 21.0 in 2013-2021. Adjusted IRRs showed a significant reduction in incidence rates across periods for all cancers combined after exclusion of nonmelanoma skin cancers (IRR = 0.90, 95% confidence interval-CI: 0.76-1.07 in 2005-2012; IRR = 0.72, 95% CI: 0.60-0.87 in 2013-2021 vs. 1997-2004; P

Identifiants

pubmed: 36831688
pii: cancers15041347
doi: 10.3390/cancers15041347
pmc: PMC9954633
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Italian Association for Research on Cancer
ID : (AIRC IG No. 19112)
Organisme : Italian Ministry of Health
ID : (Ricerca Corrente to IRCCS INMI L. Spallanzani, and Ricerca Corrente to IRCCS CRO Aviano)
Organisme : CRO Aviano "5x1000 (Redditi 2018)"
ID : - Seed Grant to MT

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Auteurs

Pierluca Piselli (P)

Department of Epidemiology and Pre-Clinical Research, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.

Diego Serraino (D)

Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.

Claudia Cimaglia (C)

Department of Epidemiology and Pre-Clinical Research, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.

Lucrezia Furian (L)

Unit of Kidney and Pancreas Transplantation, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, 35128 Padova, Italy.

Luigi Biancone (L)

Division of Nephrology Dialysis and Transplantation, Renal Transplantation Center "A. Vercellone", Città della Salute e della Scienza University Hospital, 10126 Turin, Italy.

Ghil Busnach (G)

Grande Ospedale Metropolitano Niguarda, 20162 Milano, Italy.

Nicola Bossini (N)

Unit of Nephrology, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.

Paola Todeschini (P)

Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, IRCCS S. Orsola Hospital, University of Bologna, 40138 Bologna, Italy.

Maurizio Iaria (M)

Department of General and Specialized Surgery, Division of General Surgery, Transplant Surgery Unit, Parma University Hospital, 43126 Parma, Italy.

Franco Citterio (F)

Department of Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Mariarosaria Campise (M)

Unit of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy.

Massimiliano Veroux (M)

Organ Transplantation Unit, Department of Medical and Surgical Sciences and Advanced Technologies, University Hospital of Catania, 95123 Catania, Italy.

Giuseppe Tisone (G)

UOC Transplant Unit, Department of Surgery, Tor Vergata University, 00133 Rome, Italy.

Vincenzo Cantaluppi (V)

Nephrology and Kidney Transplantation Unit, Department of Translational Medicine, University of Piemonte Orientale (UPO), "Maggiore della Carità" University Hospital, 28100 Novara, Italy.

Margherita Mangino (M)

Nephrology, Dialysis, Transplantation Unit, Ca' Foncello Hospital, 31100 Treviso, Italy.

Simona Simone (S)

Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.

Davide Argiolas (D)

Renal Transplant Unit, Azienda Ospedaliera Brotzu, 09047 Cagliari, Italy.

Andrea Ambrosini (A)

Renal Transplant Unit, Azienda Ospedaliera Ospedale di Circolo e Fondazione Macchi, 21100 Varese, Italy.

Francesco Pisani (F)

General and Transplant Surgery Department, University of L'Aquila, 67100 L'Aquila, Italy.

Flavia Caputo (F)

Nephrology Dialysis and Renal Transplant Department, Civico and Di Cristina Hospital, 90127 Palermo, Italy.

Martina Taborelli (M)

Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.

Classifications MeSH