Embryoid Body Cells from Human Embryonic Stem Cells Overexpressing Dopaminergic Transcription Factors Survive and Initiate Neurogenesis via Neural Rosettes in the Substantia Nigra.
embryoid body cells
human embryonic stem cells
neural rosettes
stem-cell transplantation
substantia nigra
transcription factors
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
14 Feb 2023
14 Feb 2023
Historique:
received:
22
12
2022
revised:
06
02
2023
accepted:
13
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Transplantation of immature dopaminergic neurons or neural precursors derived from embryonic stem cells (ESCs) into the substantia nigra pars compacta (SNpc) is a potential therapeutic approach for functional restitution of the nigrostriatal pathway in Parkinson's disease (PD). However, further studies are needed to understand the effects of the local microenvironment on the transplanted cells to improve survival and specific differentiation in situ. We have previously reported that the adult SNpc sustains a neurogenic microenvironment. Non-neuralized embryoid body cells (EBCs) from mouse ESCs (mESCs) overexpressing the dopaminergic transcription factor
Identifiants
pubmed: 36831872
pii: brainsci13020329
doi: 10.3390/brainsci13020329
pmc: PMC9954545
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : DGAPA-PAPIIT
ID : IN211419
Organisme : DGAPA-PAPIIT
ID : IN219623
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : A1-S-10064
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : CVU 768446
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : CVU 699541
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : CVU 767791
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : CVU 1037918
Organisme : DGAPA-PAPIIT
ID : IA205423
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