Long-Term Outcome Following Liver Transplantation for Primary Hepatic Tumors-A Single Centre Observational Study over 40 Years.
AFP
biliary complication
hepatoblastoma
liver malignancy
long-term outcome
pediatric liver transplantation
salvage transplant
tumor recurrence
Journal
Children (Basel, Switzerland)
ISSN: 2227-9067
Titre abrégé: Children (Basel)
Pays: Switzerland
ID NLM: 101648936
Informations de publication
Date de publication:
22 Jan 2023
22 Jan 2023
Historique:
received:
02
12
2022
revised:
11
01
2023
accepted:
17
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
The incidence of pediatric liver tumors in general has been rising over the last years and so is the number of children undergoing liver transplantation for this indication. To contribute to the ongoing improvement of pre- and post-transplant care, we aim to describe outcome and risk factors in our patient cohort. We have compared characteristics and outcome for patients transplanted for hepatoblastoma to other liver malignancies in our center between 1983 and 2022 and analysed influential factors on tumor recurrence and mortality using nominal logistic regression analysis. Of 39 children (16 f) who had transplants for liver malignancy, 31 were diagnosed with hepatoblastoma. The proportion of malignant tumors in the transplant cohort rose from 1.9% (1983-1992) to 9.1% in the current decade (
Identifiants
pubmed: 36832331
pii: children10020202
doi: 10.3390/children10020202
pmc: PMC9954409
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Pediatrics. 2022 Oct 1;150(4):
pubmed: 36111446
Pediatr Transplant. 2018 Jun 11;:e13250
pubmed: 29888545
Am J Transplant. 2022 May;22(5):1396-1408
pubmed: 34990053
N Engl J Med. 2018 Jun 21;378(25):2376-2385
pubmed: 29924955
Curr Opin Pediatr. 2014 Jun;26(3):362-9
pubmed: 24759227
J Pediatr Surg. 2017 Oct 12;:
pubmed: 29108844
Liver Transpl. 2022 Mar;28(3):454-465
pubmed: 34365719
Liver Transpl. 2017 Dec;23(12):1577-1588
pubmed: 28834194
Cancer Commun (Lond). 2019 Oct 24;39(1):62
pubmed: 31651371
Children (Basel). 2021 Jul 27;8(8):
pubmed: 34438532
Pediatr Transplant. 2011 Aug;15(5):510-4
pubmed: 21696525
Front Biosci (Elite Ed). 2012 Jan 01;4(1):493-8
pubmed: 22201890
J Pediatr Surg. 2007 May;42(5):834-9
pubmed: 17502194
Transl Gastroenterol Hepatol. 2016 May 20;1:44
pubmed: 28138611
Pediatr Radiol. 2007 Feb;37(2):123-32; quiz 249-50
pubmed: 17186233
Pediatr Transplant. 2019 May;23(3):e13369
pubmed: 30719825
Lancet Child Adolesc Health. 2021 Apr;5(4):274-283
pubmed: 33581749
J Pediatr Surg. 2006 Jan;41(1):182-6
pubmed: 16410130
Transplantation. 2001 Sep 15;72(5):851-5
pubmed: 11571449
Pediatr Transplant. 2020 Feb;24(1):e13605
pubmed: 31680409
Pediatr Transplant. 2018 Dec;22(8):e13305
pubmed: 30341782
World J Hepatol. 2015 Aug 28;7(18):2162-70
pubmed: 26328028
Pediatr Transplant. 2004 Jun;8(3):243-8
pubmed: 15176961
Lancet Child Adolesc Health. 2020 Feb;4(2):141-150
pubmed: 31866182
Pediatr Blood Cancer. 2022 Oct;69(10):e29763
pubmed: 35591805
Liver Transpl. 2018 Feb;24(2):246-255
pubmed: 29222922
J Am Coll Surg. 2019 Jul;229(1):69-77.e2
pubmed: 30905856
Pediatr Transplant. 2018 Mar;22(2):
pubmed: 29341393
Hepatol Int. 2022 Feb;16(1):125-134
pubmed: 34506008