Ablation of
GABA receptor
anxiety
behavior
corticosterone
mouse model
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
21 01 2023
21 01 2023
Historique:
received:
26
10
2022
revised:
07
01
2023
accepted:
17
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
Stress responses are activated by the hypothalamic-pituitary-adrenal axis (HPA axis), culminating in the release of glucocorticoids. During prolonged periods of secretion of glucocorticoids or inappropriate behavioral responses to a stressor, pathologic conditions may occur. Increased glucocorticoid concentration is linked to generalized anxiety, and there are knowledge gaps regarding its regulation. It is known that the HPA axis is under GABAergic control, but the contribution of the individual subunits of the GABA receptor is largely unknown. In this study, we investigated the relationship between the α5 subunit and corticosterone levels in a new mouse model deficient for
Identifiants
pubmed: 36833213
pii: genes14020285
doi: 10.3390/genes14020285
pmc: PMC9956889
pii:
doi:
Substances chimiques
Corticosterone
W980KJ009P
Glucocorticoids
0
Receptors, GABA
0
GABRA5 protein, human
0
Receptors, GABA-A
0
Gabra5 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Indian J Endocrinol Metab. 2012 Dec;16(Suppl 3):S627-36
pubmed: 23565499
Front Mol Neurosci. 2019 Jul 24;12:179
pubmed: 31396049
Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3662-7
pubmed: 14993607
J Neurosci. 2002 Jul 1;22(13):5572-80
pubmed: 12097508
Rev Neurosci. 2006;17(1-2):111-33
pubmed: 16703946
Nurs Forum. 2014 Jan-Mar;49(1):71-4
pubmed: 24456555
Neuropsychopharmacology. 2010 Jan;35(1):169-91
pubmed: 19625997
Brain Struct Funct. 2008 Sep;213(1-2):63-72
pubmed: 18696110
J Neurophysiol. 2007 Oct;98(4):2244-54
pubmed: 17715197
Front Behav Neurosci. 2014 Aug 08;8:273
pubmed: 25152721
Neuropharmacology. 2009 Jan;56(1):141-8
pubmed: 18760291
J Neurosci. 2011 Dec 14;31(50):18198-210
pubmed: 22171026
Front Genet. 2012 Oct 26;3:222
pubmed: 23112806
Cells. 2020 Apr 16;9(4):
pubmed: 32316223
J Neurosci. 2019 Jan 30;39(5):788-801
pubmed: 30523065
Front Neurosci. 2011 Dec 05;5:131
pubmed: 22164129
J Neurosci. 2010 Apr 14;30(15):5269-82
pubmed: 20392949
Biochem Soc Trans. 2009 Dec;37(Pt 6):1334-7
pubmed: 19909271
Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5573-8
pubmed: 18391224
Sci Rep. 2019 Oct 23;9(1):15211
pubmed: 31645617
Neuropsychopharmacology. 2014 Sep;39(10):2423-31
pubmed: 24755890
Br J Pharmacol. 2011 Oct;164(4):1129-61
pubmed: 21545412
Med Sci Monit. 2005 Apr;11(4):RA136-45
pubmed: 15795710
Neuron. 2018 Feb 7;97(3):670-683.e6
pubmed: 29397273
Physiol Behav. 2014 Jun 22;133:30-8
pubmed: 24832050
Dialogues Clin Neurosci. 2006;8(4):383-95
pubmed: 17290797
Compr Physiol. 2016 Mar 15;6(2):603-21
pubmed: 27065163
Front Mol Neurosci. 2021 Jan 11;13:614435
pubmed: 33505245
J Neurophysiol. 2006 May;95(5):2796-807
pubmed: 16452257
Stress. 2018 Sep;21(5):443-452
pubmed: 29451062
PLoS Genet. 2017 Jul 13;13(7):e1006780
pubmed: 28704371
Appl Clin Genet. 2014 May 16;7:93-104
pubmed: 24876791
Anesthesiology. 2009 Nov;111(5):1025-35
pubmed: 19809285
Front Neuroendocrinol. 2014 Apr;35(2):180-196
pubmed: 24361584
Neuropsychopharmacology. 2016 Sep;41(10):2492-501
pubmed: 27067130
Am J Physiol Renal Physiol. 2020 Jul 1;319(1):F115-F124
pubmed: 32475134
Cell Rep. 2017 Dec 12;21(11):3022-3031
pubmed: 29241532
Front Pharmacol. 2016 Nov 22;7:446
pubmed: 27920723
Endocr Connect. 2017 Feb;6(2):R1-R7
pubmed: 28119322
Prog Neuropsychopharmacol Biol Psychiatry. 2002 Dec;26(7-8):1389-92
pubmed: 12502028
Nature. 2001 Jan 4;409(6816):88-92
pubmed: 11343119
Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8980-5
pubmed: 12084936
Adv Exp Med Biol. 2020;1191:367-388
pubmed: 32002938
Front Mol Neurosci. 2018 Feb 06;11:18
pubmed: 29467616
J Comp Neurol. 1996 Apr 22;368(1):88-99
pubmed: 8725295
J Vis Exp. 2014 Mar 01;(85):
pubmed: 24637495
Mol Metab. 2020 Jun;36:100972
pubmed: 32229097
J Comp Neurol. 2006 Nov 20;499(3):458-70
pubmed: 16998906
PLoS One. 2013;8(3):e58679
pubmed: 23516534
J Neurosci. 2008 Feb 6;28(6):1421-6
pubmed: 18256262