COMT but Not 5HTTLPR Gene Is Associated with Depression in First-Episode Psychosis: The Role of Stressful Life Events.
5-HTTLPR
COMT
depression
first-episode psychosis
stressful life events
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
29 01 2023
29 01 2023
Historique:
received:
19
12
2022
revised:
10
01
2023
accepted:
26
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
Serotonergic and dopaminergic systems are involved in the regulation of mood and reactivity to psychological stress. This study explores, in a sample of first episode psychosis (FEP) patients, whether more severe depressive symptoms were found in those who: (1) experienced a major stressful event in the 6 months preceding illness onset; and (2) were homozygous for the COMT Val158 allele or carrying the S allele of 5-HTTLPR. A total of 186 FEP patients recruited were assessed using the Hamilton Rating Scale for Depression (HAMD) for depressive symptoms. Stressful life events (SLEs) were collected by the List of Events Scale. The genotypes of 5-HTTLPR, rs25531, and COMT Val158 Met were performed. It has been found that higher levels of depression is associated with the presence of SLEs (
Identifiants
pubmed: 36833277
pii: genes14020350
doi: 10.3390/genes14020350
pmc: PMC9956580
pii:
doi:
Substances chimiques
COMT protein, human
EC 2.1.1.6
Catechol O-Methyltransferase
EC 2.1.1.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Psychol Rev. 2019 Nov;126(6):791-816
pubmed: 31414874
Mol Psychiatry. 2007 May;12(5):421-2
pubmed: 17453058
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:54-63
pubmed: 23602950
Epidemiol Psychiatr Sci. 2012 Sep;21(3):281-303
pubmed: 22794251
Mol Psychiatry. 2001 May;6(3):350-2
pubmed: 11326308
J Psychiatry Neurosci. 2013 Nov;38(6):366-80
pubmed: 23527885
Am J Psychiatry. 2006 Jan;163(1):48-51
pubmed: 16390888
Schizophr Bull. 2009 May;35(3):638-45
pubmed: 18245057
Neuroscientist. 2003 Oct;9(5):404-16
pubmed: 14580124
Behav Brain Res. 2011 Jan 1;216(1):53-8
pubmed: 20620172
Genes (Basel). 2021 Nov 26;12(12):
pubmed: 34946845
Arch Gen Psychiatry. 1971 Oct;25(4):340-7
pubmed: 5116988
Psychiatr Genet. 2010 Apr;20(2):49-58
pubmed: 20016401
Psychol Med Monogr Suppl. 1992;20:1-97
pubmed: 1565705
Neuroscience. 2009 Nov 24;164(1):72-87
pubmed: 19446012
Child Abuse Negl. 2010 Jun;34(6):387-95
pubmed: 20403637
Am J Hum Genet. 2006 May;78(5):815-826
pubmed: 16642437
J Psychosom Res. 1967 Aug;11(2):213-8
pubmed: 6059863
Mol Psychiatry. 2005 Aug;10(8):765-70
pubmed: 15824744
Stress. 2014 Sep;17(5):410-5
pubmed: 25068285
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):934-9
pubmed: 20450949
Transl Psychiatry. 2017 Feb 21;7(2):e1042
pubmed: 28221367
Science. 1996 Nov 29;274(5292):1527-31
pubmed: 8929413
Annu Rev Clin Psychol. 2018 May 7;14:1-28
pubmed: 29328780
Schizophr Res. 2007 Sep;95(1-3):253-5
pubmed: 17644310
Acta Psychiatr Scand. 2009 Feb;119(2):117-27
pubmed: 19016667
Am J Psychiatry. 2019 May 1;176(5):376-387
pubmed: 30845820
Mol Psychiatry. 2006 Mar;11(3):224-6
pubmed: 16402131
Psychol Med. 2019 Nov;49(15):2463-2474
pubmed: 31524121
Mol Psychiatry. 2018 Jan;23(1):133-142
pubmed: 28373689
Schizophr Bull. 1987;13(2):261-76
pubmed: 3616518
Schizophr Res. 2007 Feb;90(1-3):186-97
pubmed: 17110087
J Neurochem. 1996 Jun;66(6):2621-4
pubmed: 8632190
Mol Psychiatry. 2022 Jul 20;:
pubmed: 35854107
J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
pubmed: 14399272
Schizophr Bull. 2013 Jul;39(4):740-7
pubmed: 23671196
Acta Psychiatr Scand. 2012 Mar;125(3):247-56
pubmed: 22128864
Aust N Z J Psychiatry. 2016 Sep;50(9):842-57
pubmed: 26979101
J Psychiatr Res. 2015 Jan;60:1-13
pubmed: 25287955
J Psychiatr Res. 2013 Apr;47(4):438-44
pubmed: 23290558
Am J Psychiatry. 2003 Mar;160(3):469-76
pubmed: 12611827
J Trauma Stress. 2013 Dec;26(6):645-53
pubmed: 24222274
Nat Rev Neurosci. 2016 Aug;17(8):524-32
pubmed: 27256556
Schizophr Res. 2021 Sep;235:91-101
pubmed: 34332429
J Neuroimmune Pharmacol. 2016 Sep;11(3):434-45
pubmed: 26803486
Child Adolesc Psychiatry Ment Health. 2021 Nov 23;15(1):70
pubmed: 34814943
Schizophr Bull. 1984;10(2):258-92
pubmed: 6729412