Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring.
assisted reproductive techniques
genetics
infertility
offspring
paternal age
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
14 02 2023
14 02 2023
Historique:
received:
10
01
2023
revised:
01
02
2023
accepted:
13
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
The average age of fathers at first pregnancy has risen significantly over the last decade owing to various variables, including a longer life expectancy, more access to contraception, later marriage, and other factors. As has been proven in several studies, women over 35 years of age have an increased risk of infertility, pregnancy problems, spontaneous abortion, congenital malformations, and postnatal issues. There are varying opinions on whether a father's age affects the quality of his sperm or his ability to father a child. First, there is no single accepted definition of old age in a father. Second, much research has reported contradictory findings in the literature, particularly concerning the most frequently examined criteria. Increasing evidence suggests that the father's age contributes to his offspring's higher vulnerability to inheritable diseases. Our comprehensive literature evaluation shows a direct correlation between paternal age and decreased sperm quality and testicular function. Genetic abnormalities, such as DNA mutations and chromosomal aneuploidies, and epigenetic modifications, such as the silencing of essential genes, have all been linked to the father's advancing years. Paternal age has been shown to affect reproductive and fertility outcomes, such as the success rate of in vitro fertilisation (IVF), intracytoplasmic sperm injection (ICSI), and premature birth rate. Several diseases, including autism, schizophrenia, bipolar disorders, and paediatric leukaemia, have been linked to the father's advanced years. Therefore, informing infertile couples of the alarming correlations between older fathers and a rise in their offspring's diseases is crucial, so that they can be effectively guided through their reproductive years.
Identifiants
pubmed: 36833413
pii: genes14020486
doi: 10.3390/genes14020486
pmc: PMC9957550
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Hum Reprod Update. 2006 Jul-Aug;12(4):417-35
pubmed: 16581810
Am J Med Genet. 1995 Nov 6;59(2):209-17
pubmed: 8588588
Nature. 2012 Apr 04;485(7397):246-50
pubmed: 22495309
Mol Hum Reprod. 2013 Aug;19(8):495-9
pubmed: 23515669
N Engl J Med. 2001 Nov 8;345(19):1388-93
pubmed: 11794171
Lancet. 2003 Jun 7;361(9373):1975-7
pubmed: 12801753
Hum Reprod. 1998 Feb;13(2):334-8
pubmed: 9557833
Lancet. 2016 Jul 2;388(10039):86-97
pubmed: 26777917
J Androl. 2006 May-Jun;27(3):414-20
pubmed: 16474017
Fertil Steril. 2009 Nov;92(5):1772-5
pubmed: 19539905
BMJ. 2012 Dec 27;345:e8508
pubmed: 23271744
Reprod Biomed Online. 2008 Sep;17(3):392-7
pubmed: 18765010
Genes Dev. 1995 Oct 1;9(19):2325-34
pubmed: 7557385
Med Res Rev. 2012 Mar;32(2):233-53
pubmed: 20549676
Best Pract Res Clin Endocrinol Metab. 2013 Aug;27(4):617-28
pubmed: 24054934
Asian J Androl. 2004 Jun;6(2):139-48
pubmed: 15154089
J Androl. 2001 Jul-Aug;22(4):604-10
pubmed: 11451357
J Androl. 2006 Nov-Dec;27(6):890-8
pubmed: 16870950
Biol Reprod. 1990 Feb;42(2):281-7
pubmed: 2110837
Int J Epidemiol. 2013 Apr;42(2):457-62
pubmed: 23382366
Ginecol Obstet Mex. 2010 Dec;78(12):669-76
pubmed: 21961373
Nat Cell Biol. 2012 Mar 18;14(4):355-65
pubmed: 22426077
Hum Reprod. 2004 Nov;19(11):2497-501
pubmed: 15319387
Arch Androl. 1982 Dec;9(4):293-6
pubmed: 6819822
Int J Androl. 2010 Feb;33(1):e221-7
pubmed: 19840147
Am J Psychiatry. 2011 Jan;168(1):82-8
pubmed: 20952457
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Fertil Steril. 2013 Jul;100(1):262-8.e1-2
pubmed: 23579004
Breast Cancer Res Treat. 2007 Sep;104(3):331-40
pubmed: 17115113
Mutat Res. 1995 Aug;344(1-2):89-94
pubmed: 7565898
J Assist Reprod Genet. 2013 Jun;30(6):843-8
pubmed: 23722935
Genomics. 2009 Dec;94(6):363-8
pubmed: 19720138
Fertil Steril. 2009 May;91(5 Suppl):2221-9
pubmed: 18440520
Fertil Steril. 2013 Oct;100(4):945-51
pubmed: 23809503
Mech Ageing Dev. 2011 Apr;132(4):149-53
pubmed: 21354438
Fertil Steril. 2001 Feb;75(2):237-48
pubmed: 11172821
JAMA Psychiatry. 2014 Apr;71(4):432-8
pubmed: 24577047
Arch Esp Urol. 2010 Apr;63(3):214-22
pubmed: 20431185
Hum Reprod. 2003 Jun;18(6):1265-72
pubmed: 12773457
Genes (Basel). 2014 Aug 20;5(3):656-70
pubmed: 25140888
Urology. 2010 Dec;76(6):1380-6
pubmed: 20573380
Chromosome Res. 2007;15(5):667-79
pubmed: 17674153
Reprod Biomed Online. 2008 Nov;17(5):595-604
pubmed: 18983742
Int J Cancer. 2017 Jun 1;140(11):2461-2472
pubmed: 28257590
Mol Autism. 2011 Apr 18;2(1):4
pubmed: 21501488
JBRA Assist Reprod. 2014 Jun 27;18(2):34-41
pubmed: 35761724
Asian J Androl. 2006 Jan;8(1):11-29
pubmed: 16372115
Cell. 2001 Sep 21;106(6):661-73
pubmed: 11572773
Future Child. 1995 Spring;5(1):176-96
pubmed: 7543353
J Clin Endocrinol Metab. 2010 Mar;95(3):1013-24
pubmed: 20089613
Mol Psychiatry. 2012 Jul;17(7):728-40
pubmed: 21647149
Int J Androl. 1999 Apr;22(2):57-67
pubmed: 10194636
BMJ. 2004 Nov 6;329(7474):1070
pubmed: 15501901
Ageing Res Rev. 2015 Jan;19:22-33
pubmed: 25462195
Am J Hum Genet. 1986 Nov;39(5):648-60
pubmed: 3788977
J Clin Endocrinol Metab. 2008 Jul;93(7):2737-45
pubmed: 18270261
Epidemiology. 1999 May;10(3):271-5
pubmed: 10230837
JAMA. 2013 Jun 19;309(23):2445-6
pubmed: 23645117
Eur J Hum Genet. 2011 Feb;19(2):145-51
pubmed: 21045871
Baillieres Best Pract Res Clin Obstet Gynaecol. 2000 Oct;14(5):839-54
pubmed: 11023804
Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10251-6
pubmed: 22689985
J Androl. 2005 Nov-Dec;26(6):741-8
pubmed: 16291969
Fertil Steril. 2011 Jan;95(1):1-8
pubmed: 20932518
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12135-9
pubmed: 17623782
Mymensingh Med J. 2012 Apr;21(2):306-15
pubmed: 22561776
Indian J Urol. 2011 Jan;27(1):74-85
pubmed: 21716893
Hum Reprod. 2002 Jun;17(6):1649-56
pubmed: 12042293
Andrologia. 2011 Jun;43(3):174-9
pubmed: 21561463
Fertil Steril. 1988 Jun;49(6):1045-51
pubmed: 3371482
Novartis Found Symp. 2002;242:66-77; discussion 77-81
pubmed: 11855695
Schizophr Res. 2011 Dec;133(1-3):120-4
pubmed: 22000939
J Urol. 2021 Jan;205(1):36-43
pubmed: 33295257
Hum Reprod. 2013 Dec;28(12):3370-6
pubmed: 24166593
Aging Male. 2002 Dec;5(4):242-7
pubmed: 12630072
Trends Genet. 1991 Feb;7(2):45-9
pubmed: 2035190
Am J Epidemiol. 2005 May 1;161(9):816-23
pubmed: 15840613
Mol Hum Reprod. 2012 Nov;18(11):517-22
pubmed: 22782639
Arch Gen Psychiatry. 2008 Sep;65(9):1034-40
pubmed: 18762589
Am J Hum Genet. 2000 Mar;66(3):768-77
pubmed: 10712195
Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9601-6
pubmed: 16766665
Hormones (Athens). 2015 Oct-Dec;14(4):479-503
pubmed: 26732153
Am J Med Genet. 2002 Apr 8;114(3):299-303
pubmed: 11920852
Sex Dev. 2011;5(2):60-9
pubmed: 21293114
Transl Androl Urol. 2016 Dec;5(6):935-950
pubmed: 28078226
Rev Reprod. 1999 Jan;4(1):31-7
pubmed: 10051100
Int J Androl. 2008 Dec;31(6):537-45
pubmed: 18298569
Mol Psychiatry. 2011 Dec;16(12):1203-12
pubmed: 21116277
Fertil Steril. 2000 Jan;73(1):43-50
pubmed: 10632410
J Pediatr. 1998 Mar;132(3 Pt 1):401-4
pubmed: 9544890
Ageing Res Rev. 2011 Jan;10(1):146-52
pubmed: 20946972
Hum Genet. 2004 Aug;115(3):200-7
pubmed: 15241680
Nat Genet. 2008 Jul;40(7):880-5
pubmed: 18511947
Am J Hum Genet. 1996 Nov;59(5):1108-13
pubmed: 8900240
J Submicrosc Cytol Pathol. 1996 Oct;28(4):587-96
pubmed: 8933742
Hum Mol Genet. 2007 Nov 1;16(21):2542-51
pubmed: 17636251
Protein Pept Lett. 2011 Aug;18(8):772-7
pubmed: 21443494
Ginekol Pol. 2016;87(12):820-823
pubmed: 28098933
J Radiat Res. 2006;47 Suppl B:B75-82
pubmed: 17019055
Mutat Res. 1991 Jan;256(1):45-8
pubmed: 1944386
Cancer. 2015 Sep 1;121(17):2863
pubmed: 26291438
Psychol Med. 2010 Mar;40(3):477-85
pubmed: 19627644
J Coll Physicians Surg Pak. 2021 Jan;31(1):4-7
pubmed: 33546525
Am J Perinatol. 2002 Jan;19(1):49-54
pubmed: 11857096
Arch Gynecol Obstet. 2013 Apr;287(4):803-7
pubmed: 23179801
Lancet. 2004 May 22;363(9422):1700-2
pubmed: 15158633
Fertil Steril. 2006 Feb;85(2):496-9
pubmed: 16595239
Eur J Hum Genet. 2013 Oct;21(10):1163-8
pubmed: 23321625
Horm Behav. 2011 Mar;59(3):306-14
pubmed: 20620140
Science. 2000 Mar 31;287(5462):2486-92
pubmed: 10741968
Fertil Steril. 2011 Jan;95(1):129-34, 134.e1-4
pubmed: 20655520
Urology. 2009 Oct;74(4):789-93
pubmed: 19643462
Hum Reprod. 2013 Jun;28(6):1455-67
pubmed: 23539611
Fertil Steril. 2013 Mar 1;99(3):673-7
pubmed: 23391408
J Androl. 1985 May-Jun;6(3):144-51
pubmed: 3997660
Fertil Steril. 2014 Oct;102(4):998-1005.e8
pubmed: 25190048
J Androl. 1995 Jul-Aug;16(4):292-8
pubmed: 8537245
Hum Reprod. 1995 May;10(5):1090-7
pubmed: 7657747
Am J Hum Genet. 2001 Nov;69(5):1046-54
pubmed: 11582569
Adv Exp Med Biol. 2014;791:13-26
pubmed: 23955670
J Clin Endocrinol Metab. 2002 Feb;87(2):589-98
pubmed: 11836290
Fertil Steril. 2006 Jan;85(1):128-34
pubmed: 16412742
Int Rev Cytol. 2002;218:37-67
pubmed: 12199519
BMC Cancer. 2005 Oct 31;5:143
pubmed: 16259637
Fertil Steril. 2021 Jun;115(6):1395-1410
pubmed: 33838871
Fertil Steril. 2010 Apr;93(6):1870-4
pubmed: 19409557
Reprod Biomed Online. 2003 Oct-Nov;7(4):428-32
pubmed: 14656403
Hum Reprod. 2006 Nov;21(11):2868-75
pubmed: 16793993
Nat Genet. 1999 Dec;23(4):429-32
pubmed: 10581029
Fertil Steril. 2013 Oct;100(4):952-8
pubmed: 23809502
Cent European J Urol. 2014;67(2):184-8
pubmed: 25140235
Curr Opin Cell Biol. 1990 Apr;2(2):301-5
pubmed: 2194529
Fertil Steril. 2013 Nov;100(5):1241-7
pubmed: 23916795
Acta Biochim Biophys Sin (Shanghai). 2010 Feb;42(2):145-53
pubmed: 20119626
Schizophr Bull. 2007 Nov;33(6):1270-3
pubmed: 17712030
Fertil Steril. 2011 Jan;95(1):116-23
pubmed: 20674912
J Assist Reprod Genet. 2016 Apr;33(4):441-54
pubmed: 26867640
Hum Reprod Update. 2003 Jul-Aug;9(4):331-45
pubmed: 12926527
Am J Hum Genet. 2012 Feb 10;90(2):175-200
pubmed: 22325359
Nature. 2012 Aug 23;488(7412):471-5
pubmed: 22914163
J Obstet Gynaecol. 2011 Jul;31(5):420-3
pubmed: 21627427
Epidemiology. 2006 Mar;17(2):218-21
pubmed: 16477263
Tohoku J Exp Med. 1969 Nov;99(3):269-80
pubmed: 5363446
Andrologia. 2007 Apr;39(2):45-50
pubmed: 17430422
Am J Hum Genet. 2010 Oct 8;87(4):505-12
pubmed: 20887963
J Biol Chem. 2000 Mar 17;275(11):7447-50
pubmed: 10713043
J Androl. 2002 Jan-Feb;23(1):25-43
pubmed: 11780920
J Biol Chem. 1999 Oct 22;274(43):30651-6
pubmed: 10521451
BMC Pregnancy Childbirth. 2010 Feb 23;10 Suppl 1:S1
pubmed: 20233382
PLoS Genet. 2008 Feb;4(2):e37
pubmed: 18282113
Nat Rev Genet. 2001 Apr;2(4):280-91
pubmed: 11283700
Mol Psychiatry. 2012 Feb;17(2):142-53
pubmed: 22083728
Fertil Steril. 2010 May 1;93(7):2247-54
pubmed: 19328484
Hum Reprod. 2014 Nov;29(11):2402-12
pubmed: 25205757
Hum Reprod Update. 2004 Jul-Aug;10(4):327-39
pubmed: 15192059
J Assist Reprod Genet. 2012 Mar;29(3):213-23
pubmed: 22290605
Ann N Y Acad Sci. 2010 Jun;1197:108-17
pubmed: 20536839
Epidemiology. 1995 May;6(3):282-8
pubmed: 7619937
Exp Gerontol. 2000 Aug;35(5):543-51
pubmed: 10978677
Nat Rev Genet. 2000 Oct;1(1):40-7
pubmed: 11262873
Nature. 2008 Dec 4;456(7222):599-604
pubmed: 18923395
Nat Commun. 2013;4:1597
pubmed: 23511462
Syst Biol Reprod Med. 2012 Jun;58(3):142-8
pubmed: 22432504
Can J Public Health. 2003 Mar-Apr;94(2):88-92
pubmed: 12675162
Obstet Gynecol. 2006 Aug;108(2):369-77
pubmed: 16880308
Arch Gen Psychiatry. 2006 Sep;63(9):1026-32
pubmed: 16953005
Schizophr Res. 2009 Oct;114(1-3):1-5
pubmed: 19683417
Andrologia. 2012 Apr;44(2):130-5
pubmed: 21714801
Hum Fertil (Camb). 2021 Feb;24(1):3-13
pubmed: 31169420
Lancet. 1995 Aug 19;346(8973):486-8
pubmed: 7637485
Fertil Steril. 2015 Jun;103(6):1379-80
pubmed: 25936233
Eur J Hum Genet. 2010 Mar;18(3):385-9
pubmed: 19826452
Methods Mol Biol. 2014;1154:25-37
pubmed: 24782004
Ageing Res Rev. 2013 Mar;12(2):661-84
pubmed: 22353384
Nat Med. 2006 Oct;12(10):1133-8
pubmed: 17024208
J Clin Endocrinol Metab. 1991 Nov;73(5):1016-25
pubmed: 1719016
Urol Res. 1999 Oct;27(5):336-45
pubmed: 10550521
Maturitas. 2014 May;78(1):22-9
pubmed: 24680129
Environ Mol Mutagen. 1995;25 Suppl 26:48-64
pubmed: 7789362
Paediatr Perinat Epidemiol. 2002 Oct;16(4):320-7
pubmed: 12445148
Schizophr Bull. 2011 Sep;37(5):1039-47
pubmed: 20185538
J Clin Endocrinol Metab. 1984 Oct;59(4):756-63
pubmed: 6434579
Hum Reprod. 2005 Mar;20(3):768-73
pubmed: 15640258
Curr Opin Genet Dev. 2014 Jun;26:89-95
pubmed: 25104620
Hum Mol Genet. 2007 Dec 15;16(24):3097-102
pubmed: 17881651
Front Endocrinol (Lausanne). 2022 Oct 13;13:1012119
pubmed: 36313743
Biol Reprod. 2004 Apr;70(4):910-8
pubmed: 14645105
Endocrinology. 2005 Sep;146(9):3926-32
pubmed: 15919739
Fertil Steril. 2007 Nov;88(5):1446-8
pubmed: 17448469
Fertil Steril. 2014 Apr;101(4):1079-1085.e3
pubmed: 24462061
Hum Reprod. 2003 May;18(5):1023-8
pubmed: 12721180
Schizophr Res. 2011 Jul;129(2-3):128-32
pubmed: 21489755
Aging Cell. 2005 Apr;4(2):97-101
pubmed: 15771613
J Clin Endocrinol Metab. 2003 Jan;88(1):179-84
pubmed: 12519849
Fertil Steril. 2011 Sep;96(3):572-6
pubmed: 21782163
Biol Reprod. 2002 Apr;66(4):1061-7
pubmed: 11906926
Curr Opin Cell Biol. 1990 Feb;2(1):28-32
pubmed: 2183839
Fertil Steril. 2003 Dec;80(6):1420-30
pubmed: 14667878
Genome Res. 2004 Apr;14(4):567-73
pubmed: 15059997
J Assist Reprod Genet. 2011 May;28(5):425-32
pubmed: 21287403
J Mol Biol. 1978 Mar 25;120(1):33-53
pubmed: 642006
Epidemiology. 2005 Mar;16(2):259-62
pubmed: 15703543
Eur Urol. 2004 Jan;45(1):87-91
pubmed: 14667522
Physiol Rev. 2008 Apr;88(2):557-79
pubmed: 18391173
Am J Obstet Gynecol. 2004 Aug;191(2):507-14
pubmed: 15343228
Hum Reprod. 2006 Nov;21(11):2876-81
pubmed: 16793992
Am J Epidemiol. 2004 Dec 15;160(12):1214-22
pubmed: 15583374
Arch Gen Psychiatry. 2001 Apr;58(4):361-7
pubmed: 11296097
Fertil Steril. 2008 Jul;90(1):97-103
pubmed: 17765235
Hum Reprod. 2012 Dec;27(12):3622-31
pubmed: 22940768
Am J Mens Health. 2012 Sep;6(5):427-35
pubmed: 22564913
PLoS One. 2007 Dec 12;2(12):e1289
pubmed: 18074014
Nature. 2012 Apr 04;485(7397):237-41
pubmed: 22495306
Hum Reprod. 2003 Feb;18(2):447-54
pubmed: 12571189
Am J Epidemiol. 2015 Jul 1;182(1):41-8
pubmed: 25964260
Urology. 2011 Jun;77(6):1343-8
pubmed: 21310465
Hum Reprod. 2002 Apr;17(4):990-8
pubmed: 11925396
Hum Reprod. 2004 Jan;19(1):129-38
pubmed: 14688171
Hum Reprod. 2000 Jun;15(6):1338-44
pubmed: 10831565
Fertil Steril. 2010 Mar 1;93(4):1142-6
pubmed: 19108827
Schizophr Res. 2005 Jul 15;76(2-3):337-42
pubmed: 15949666
Fertil Steril. 2014 Jun;101(6):1552-62
pubmed: 24882619
Eur J Paediatr Neurol. 2009 May;13(3):269-70
pubmed: 18824378
Dev Cell. 2022 May 9;57(9):1160-1176.e5
pubmed: 35504286
Reprod Biomed Online. 2006 Apr;12(4):466-72
pubmed: 16740220
Am J Epidemiol. 2008 Dec 1;168(11):1268-76
pubmed: 18945690