Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review.
centrifugation
extracellular vesicles
fresh-frozen plasma
intercellular signaling peptides and proteins
platelet-rich plasma
platelets
regeneration
small cellular particles
wound healing
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Feb 2023
08 Feb 2023
Historique:
received:
31
12
2022
revised:
24
01
2023
accepted:
30
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has been explored in many medical fields with the aim to benefit from its healing potential. In parallel, efforts are being invested to understand the function and dynamics of PVRP that is complex in its composition and interactions. Some clinical evidence reveals beneficial effects of PVRP, while some report that there were no effects. To optimize the preparation methods, functions and mechanisms of PVRP, its constituents should be better understood. With the intention to promote further studies of autologous therapeutic PVRP, we performed a review on some topics regarding PVRP composition, harvesting, assessment and preservation, and also on clinical experience following PVRP application in humans and animals. Besides the acknowledged actions of platelets, leukocytes and different molecules, we focus on extracellular vesicles that were found abundant in PVRP.
Identifiants
pubmed: 36834843
pii: ijms24043420
doi: 10.3390/ijms24043420
pmc: PMC9959846
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Slovenian Research Agency
ID : P01-0201-Physical Chemistry, P1-0391, P2-0232, P3-0374, P3-0388, J2-4447, J3-3066 and L3-2621
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