Inhibition of Myeloperoxidase Pro-Fibrotic Effect by Noscapine in Equine Endometrium.
collagen
endometrosis
equine
fibrosis
inhibition
myeloperoxidase
noscapine
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Feb 2023
10 Feb 2023
Historique:
received:
16
12
2022
revised:
06
02
2023
accepted:
09
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
Myeloperoxidase is an enzyme released by neutrophils when neutrophil extracellular traps (NETs) are formed. Besides myeloperoxidase activity against pathogens, it was also linked to many diseases, including inflammatory and fibrotic ones. Endometrosis is a fibrotic disease of the mare endometrium, with a large impact on their fertility, where myeloperoxidase was shown to induce fibrosis. Noscapine is an alkaloid with a low toxicity, that has been studied as an anti-cancer drug, and more recently as an anti-fibrotic molecule. This work aims to evaluate noscapine inhibition of collagen type 1 (COL1) induced by myeloperoxidase in equine endometrial explants from follicular and mid-luteal phases, at 24 and 48 h of treatment. The transcription of collagen type 1 alpha 2 chain (
Identifiants
pubmed: 36835008
pii: ijms24043593
doi: 10.3390/ijms24043593
pmc: PMC9959736
pii:
doi:
Substances chimiques
Collagen
9007-34-5
Collagen Type I, alpha2 Subunit
0
Noscapine
8V32U4AOQU
Peroxidase
EC 1.11.1.7
RNA, Messenger
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação para a Ciência e Tecnologia
ID : UIDB/00276/2020; LA/P/0059/2020
Organisme : Fundação para a Ciência e Tecnologia
ID : PTDC/CVT-REP/4202/2014
Organisme : Fundação para a Ciência e Tecnologia
ID : SFRH/BD/101058/2014
Organisme : Narodowa Agencja Wymiany Akademickiej (NAWA)
ID : PPN/BIL/2018/1/00250/U/0001
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