Caspase Inhibition Modulates Monocyte-Derived Macrophage Polarization in Damaged Tissues.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
19 Feb 2023
Historique:
received: 17 12 2022
revised: 16 02 2023
accepted: 16 02 2023
entrez: 25 2 2023
pubmed: 26 2 2023
medline: 3 3 2023
Statut: epublish

Résumé

Circulating monocytes are recruited in damaged tissues to generate macrophages that modulate disease progression. Colony-stimulating factor-1 (CSF-1) promotes the generation of monocyte-derived macrophages, which involves caspase activation. Here, we demonstrate that activated caspase-3 and caspase-7 are located to the vicinity of the mitochondria in CSF1-treated human monocytes. Active caspase-7 cleaves p47

Identifiants

pubmed: 36835566
pii: ijms24044151
doi: 10.3390/ijms24044151
pmc: PMC9964254
pii:
doi:

Substances chimiques

Macrophage Colony-Stimulating Factor 81627-83-0
Caspase 7 EC 3.4.22.-
Caspases EC 3.4.22.-
Reactive Oxygen Species 0
NADPH Oxidases EC 1.6.3.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Stéphanie Solier (S)

INSERM U1170, Gustave Roussy, 94805 Villejuif, France.
Faculty of Medicine, Université Paris-Sud, 94270 Le Kremlin-Bicêtre, France.
Laboratoire d'Excellence LipSTIC, 21000 Dijon, France.

Michele Mondini (M)

INSERM UMR1030, Gustave Roussy, 94805 Villejuif, France.

Lydia Meziani (L)

INSERM UMR1030, Gustave Roussy, 94805 Villejuif, France.

Arnaud Jacquel (A)

INSERM U1065/C3M, 06204 Nice, France.

Catherine Lacout (C)

INSERM U1170, Gustave Roussy, 94805 Villejuif, France.
Faculty of Medicine, Université Paris-Sud, 94270 Le Kremlin-Bicêtre, France.

Tom Vanden Berghe (TV)

Inflammation Research Center (IRC), VIB, 9052 Ghent, Belgium.
Department of Biomedical Molecular Biology, University of Ghent, 9000 Ghent, Belgium.

Yvon Julé (Y)

Biocellvia, 13001 Marseille, France.

Jean-Claude Martinou (JC)

Department of Cell Biology, University of Geneva, 1211 Geneva, Switzerland.

Gérard Pierron (G)

CNRS UMR8122, Gustave Roussy, Villejuif, 94805, France.

Julie Rivière (J)

INSERM U1170, Gustave Roussy, 94805 Villejuif, France.
Faculty of Medicine, Université Paris-Sud, 94270 Le Kremlin-Bicêtre, France.

Marc Deloger (M)

AMMICa, INSERM US23, CNRS UMS 3655, Gustave Roussy, 94805 Villejuif, France.

Corinne Dupuy (C)

CNRS UMR8200, Gustave Roussy, 94805 Villejuif, France.

Anny Slama-Schwok (A)

CNRS UMR8200, Gustave Roussy, 94805 Villejuif, France.

Nathalie Droin (N)

Faculty of Medicine, Université Paris-Sud, 94270 Le Kremlin-Bicêtre, France.
INSERM U1287, Gustave Roussy, 94805 Villejuif, France.

Peter Vandenabeele (P)

Inflammation Research Center (IRC), VIB, 9052 Ghent, Belgium.
Department of Biomedical Molecular Biology, University of Ghent, 9000 Ghent, Belgium.

Patrick Auberger (P)

INSERM U1065/C3M, 06204 Nice, France.

Eric Deutsch (E)

INSERM UMR1030, Gustave Roussy, 94805 Villejuif, France.

Jamel El-Benna (J)

Centre de Recherche sur l'Inflammation (CRI), Laboratoire d'Excellence Inflamex, Faculté de Médecine Xavier Bichat, Université de Paris, INSERM-U1149, CNRS-ERL8252, 75018 Paris, France.

Pham My-Chan Dang (PM)

Centre de Recherche sur l'Inflammation (CRI), Laboratoire d'Excellence Inflamex, Faculté de Médecine Xavier Bichat, Université de Paris, INSERM-U1149, CNRS-ERL8252, 75018 Paris, France.

Eric Solary (E)

Faculty of Medicine, Université Paris-Sud, 94270 Le Kremlin-Bicêtre, France.
INSERM U1287, Gustave Roussy, 94805 Villejuif, France.

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Classifications MeSH