Effect of Acetazolamide on Postural Control in Patients with COPD Travelling to 3100 m Randomized Trial.
COPD
acetazolamide
high-altitude
hypoxemia
hypoxia
postural control
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
04 Feb 2023
04 Feb 2023
Historique:
received:
03
11
2022
revised:
26
01
2023
accepted:
29
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Patients with chronic obstructive pulmonary disease (COPD) may be susceptible to impairments in postural control (PC) when exposed to hypoxia at high altitude. This randomized, placebo-controlled, double-blind, parallel-design trial evaluated the effect of preventive acetazolamide treatment on PC in lowlanders with COPD traveling to 3100 m. 127 lowlanders (85 men, 42 women) with moderate to severe COPD, aged 57 ± 8 y, living below 800 m, were randomized to treatment with acetazolamide 375 mg/d starting 24 h before ascent from 760 m to 3100 m and during a 2-day sojourn in a clinic at 3100 m. PC was evaluated at both altitudes with a balance platform on which patients were standing during five tests of 30 s each. The primary outcome was the center of pressure path length (COPL). In the placebo group, COPL significantly increased from (mean ± SD) 28.8 ± 9.7 cm at 760 m to 30.0 ± 10.0 cm at 3100 m (
Identifiants
pubmed: 36835782
pii: jcm12041246
doi: 10.3390/jcm12041246
pmc: PMC9960941
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Suva
ID : NA
Organisme : Swiss National Science Foundation
ID : 32003B_172980
Organisme : Lunge Zurich
ID : NA
Références
Neurosci Res. 2016 Mar;104:96-104
pubmed: 26746115
Eur J Appl Physiol. 2010 Oct;110(3):539-47
pubmed: 20549513
Pharmacol Res Perspect. 2016 May 19;4(3):e00203
pubmed: 27433337
Aviat Space Environ Med. 1982 Jul;53(7):647-51
pubmed: 7115252
Gait Posture. 2015 Feb;41(2):482-7
pubmed: 25555361
Gait Posture. 2010 Mar;31(3):307-10
pubmed: 20005112
Neurobiol Aging. 1989 Nov-Dec;10(6):727-38
pubmed: 2697808
High Alt Med Biol. 2001 Winter;2(4):509-14
pubmed: 11809091
Gerontology. 2006;52(1):1-16
pubmed: 16439819
J Cardiopulm Rehabil. 2004 Jul-Aug;24(4):274-80
pubmed: 15286536
High Alt Med Biol. 2002 Fall;3(3):283-7
pubmed: 12396882
Dan Med J. 2014 Jan;61(1):B4775
pubmed: 24393594
Trends Pharmacol Sci. 2002 Feb;23(2):83-9
pubmed: 11830265
JAMA. 2017 Nov 14;318(18):1810-1819
pubmed: 29136449
Gait Posture. 2014 Jan;39(1):224-8
pubmed: 23910725
J Travel Med. 2012 Sep-Oct;19(5):298-307
pubmed: 22943270
PLoS One. 2015 Feb 27;10(2):e0116695
pubmed: 25723529
Exp Brain Res. 2002 Jun;144(3):293-302
pubmed: 12021811
Neurotoxicol Teratol. 2013 Jan-Feb;35:28-33
pubmed: 23280141
Med Care. 1989 Mar;27(3 Suppl):S178-89
pubmed: 2646488
Clin Biomech (Bristol, Avon). 2015 Jun;30(5):481-4
pubmed: 25796535
Age Ageing. 2017 Nov 1;46(6):964-970
pubmed: 28531243
Neurosci Biobehav Rev. 2012 Jan;36(1):162-76
pubmed: 21645543
J Alzheimers Dis. 2009;16(1):113-20
pubmed: 19158427
Eur J Appl Physiol. 2002 Feb;86(4):322-6
pubmed: 11990745
High Alt Med Biol. 2018 Mar;19(1):4-6
pubmed: 29583031
Gait Posture. 2016 Jan;43:101-7
pubmed: 26471324
Int J Chron Obstruct Pulmon Dis. 2015 Jun 29;10:1233-9
pubmed: 26170652
Aviat Space Environ Med. 2011 May;82(5):518-22
pubmed: 21614865
J Med Signals Sens. 2011 Jan;1(1):55-61
pubmed: 22606659
Front Physiol. 2018 Jun 22;9:752
pubmed: 29988503
PLoS One. 2018 Jan 17;13(1):e0190919
pubmed: 29342191
Aviat Space Environ Med. 1983 Dec;54(12 Pt 1):1063-73
pubmed: 6661120