Blood Type A1 Mismatch Does Not Affect Heart Transplant Outcomes at One Year.
ABO subtype
heart transplant
rejection
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
08 Feb 2023
08 Feb 2023
Historique:
received:
20
12
2022
revised:
01
02
2023
accepted:
06
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
There are subtypes within blood type A, termed non-A1, that have reduced expression of A antigen on cell surfaces. This can result in the development of anti-A1 antibodies. There is limited information regarding the impact of this in heart transplant (HTx) recipients. We conducted a single-center cohort study of 142 Type A HTx recipients in which we compared outcomes of a match group (an A1/O heart into an A1 recipient or a non-A1/O heart into a non-A1 recipient) with a mismatch group (an A1 heart into a non-A1 recipient or a non-A1 heart into an A1 recipient). At one year post-transplant, there were no differences between the groups in survival, freedom from non-fatal major adverse cardiovascular events, freedom from any treated rejection, or freedom from cardiac allograft vasculopathy. There was an increased hospital length of stay in the mismatch group (13.5 vs. 17.1 days,
Identifiants
pubmed: 36835873
pii: jcm12041337
doi: 10.3390/jcm12041337
pmc: PMC9961239
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Cedars-Sinai Smidt Heart Institute
ID : 233046
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