Risk-Reducing Breast and Gynecological Surgery for BRCA Mutation Carriers: A Narrative Review.
BRCA
breast cancer
endometrial cancer
gene mutation carrier
ovarian cancer
pathogenetic gene mutations
risk-reducing surgery
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
10 Feb 2023
10 Feb 2023
Historique:
received:
11
01
2023
revised:
04
02
2023
accepted:
07
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
This narrative review aims to clarify the role of breast and gynecological risk-reduction surgery in BRCA mutation carriers. We examine the indications, contraindications, complications, technical aspects, timing, economic impact, ethical issues, and prognostic benefits of the most common prophylactic surgical options from the perspectives of a breast surgeon and a gynecologist. A comprehensive literature review was conducted using the PubMed/Medline, Scopus, and EMBASE databases. The databases were explored from their inceptions to August 2022. Three independent reviewers screened the items and selected those most relevant to this review's scope. BRCA1/2 mutation carriers are significantly more likely to develop breast, ovarian, and serous endometrial cancer. Because of the Angelina effect, there has been a significant increase in bilateral risk-reducing mastectomy (BRRM) since 2013. BRRM and risk-reducing salpingo-oophorectomy (RRSO) significantly reduce the risk of developing breast and ovarian cancer. RRSO has significant side effects, including an impact on fertility and early menopause (i.e., vasomotor symptoms, cardiovascular disease, osteoporosis, cognitive impairment, and sexual dysfunction). Hormonal therapy can help with these symptoms. Because of the lower risk of developing breast cancer in the residual mammary gland tissue after BRRM, estrogen-only treatments have an advantage over an estrogen/progesterone combined treatment. Risk-reducing hysterectomy allows for estrogen-only treatments and lowers the risk of endometrial cancer. Although prophylactic surgery reduces the cancer risk, it has disadvantages associated with early menopause. A multidisciplinary team must carefully inform the woman who chooses this path of the broad spectrum of implications, from cancer risk reduction to hormonal therapies.
Identifiants
pubmed: 36835955
pii: jcm12041422
doi: 10.3390/jcm12041422
pmc: PMC9967164
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Genes (Basel). 2019 Dec 16;10(12):
pubmed: 31888263
JAMA. 2012 Jan 25;307(4):382-90
pubmed: 22274685
Am J Obstet Gynecol. 2022 Mar;226(3):386.e1-386.e9
pubmed: 34688595
N Engl J Med. 1999 Jan 14;340(2):77-84
pubmed: 9887158
BMC Cancer. 2015 Nov 25;15:936
pubmed: 26608569
Am J Obstet Gynecol. 1952 Feb;63(2):400-7
pubmed: 14894551
JAMA Netw Open. 2021 Sep 1;4(9):e2123616
pubmed: 34499134
Climacteric. 2016 Apr;19(2):109-50
pubmed: 26872610
Menopause. 2020 Jan;27(1):14-19
pubmed: 31738734
Obstet Gynecol. 1977 Jan;49(1):92-6
pubmed: 831167
Nat Rev Cancer. 2007 Jan;7(1):46-53
pubmed: 17186017
Br J Cancer. 2005 Aug 8;93(3):287-92
pubmed: 16052221
Ann Surg Oncol. 2022 Oct;29(11):6660-6668
pubmed: 35616744
Ann Surg. 2014 Dec;260(6):1000-10
pubmed: 24950272
JAMA. 2006 Jun 21;295(23):2727-41
pubmed: 16754727
Breast Cancer Res Treat. 2014 Apr;144(3):443-55
pubmed: 24567198
Clin Cancer Res. 2016 Aug 1;22(15):3971-81
pubmed: 26979395
Gynecol Oncol. 2021 Mar;160(3):755-762
pubmed: 33309051
BMC Cancer. 2011 Feb 23;11:83
pubmed: 21342533
Cancers (Basel). 2022 Jul 24;14(15):
pubmed: 35892866
Gynecol Oncol. 2019 Apr;153(1):192-200
pubmed: 30661763
Menopause Int. 2011 Dec;17(4):132-6
pubmed: 22120945
Ann Surg Oncol. 2020 Jul;27(7):2288-2296
pubmed: 32390098
J Pers Med. 2022 May 18;12(5):
pubmed: 35629239
J Clin Oncol. 2007 Apr 10;25(11):1329-33
pubmed: 17416853
Eur J Cancer. 2020 Sep;136:169-175
pubmed: 32698099
Lancet Oncol. 2015 Jan;16(1):67-75
pubmed: 25497694
Obstet Gynecol. 2013 Jan;121(1):14-24
pubmed: 23232752
Lancet. 2016 Mar 5;387(10022):945-956
pubmed: 26707054
Obstet Gynecol. 2020 Jun;135(6):1267-1269
pubmed: 32459416
Am J Surg Pathol. 2007 Feb;31(2):161-9
pubmed: 17255760
J Natl Compr Canc Netw. 2021 Nov;19(11):1212-1217
pubmed: 34781271
J Clin Oncol. 2014 May 20;32(15):1547-53
pubmed: 24567435
Breast Cancer Res Treat. 2018 Dec;172(3):679-687
pubmed: 30203341
Maturitas. 2022 Sep;163:1-14
pubmed: 35569270
JAMA. 2017 Jun 20;317(23):2402-2416
pubmed: 28632866
Obstet Gynecol. 2020 Jun;135(6):1270-1274
pubmed: 32459417
J Pathol. 2001 Nov;195(4):451-6
pubmed: 11745677
N Engl J Med. 2021 Feb 4;384(5):428-439
pubmed: 33471991
Cancer Cell Int. 2021 Sep 25;21(1):512
pubmed: 34563200
J Natl Cancer Inst. 1998 Sep 16;90(18):1371-88
pubmed: 9747868
Obstet Gynecol. 2009 Sep;114(3):581-584
pubmed: 19701038
Gynecol Oncol. 2002 Oct;87(1):52-6
pubmed: 12468342
Lancet. 2000 Jun 10;355(9220):2015-20
pubmed: 10885351
Br J Cancer. 2019 Jul;121(1):15-21
pubmed: 30971774
Ann Oncol. 2013 Dec;24 Suppl 10:x16-21
pubmed: 24265397
J Cancer Res Clin Oncol. 2017 Oct;143(10):2011-2024
pubmed: 28664449
Aging (Albany NY). 2021 Nov 27;13(22):24686-24709
pubmed: 34837690
Front Public Health. 2022 Sep 15;10:975829
pubmed: 36187690
Lancet Oncol. 2006 Oct;7(10):821-8
pubmed: 17012044
BMC Womens Health. 2014 Dec 12;14:150
pubmed: 25494812
Gynecol Oncol. 2011 Aug;122(2):339-43
pubmed: 21531449
J Clin Med. 2022 May 31;11(11):
pubmed: 35683509
Bull Cancer. 2021 Nov;108(11):999-1009
pubmed: 34556291
Breast Cancer Res Treat. 2016 Jun;157(2):319-327
pubmed: 27117159
Menopause. 2009 Jan-Feb;16(1):15-23
pubmed: 19034050
Eur J Health Econ. 2022 Jul;23(5):807-821
pubmed: 34767113
Breast. 2017 Aug;34 Suppl 1:S82-S84
pubmed: 28673535
J Natl Cancer Inst. 2021 Sep 4;113(9):1203-1211
pubmed: 33710348
JAMA. 2010 Sep 1;304(9):967-75
pubmed: 20810374
J Natl Cancer Inst. 2021 Sep 4;113(9):1127-1128
pubmed: 33710310
J Clin Oncol. 2005 Jan 1;23(1):127-32
pubmed: 15625367
J Natl Cancer Inst. 2009 Jan 21;101(2):80-7
pubmed: 19141781
Oncologist. 2004;9(5):507-17
pubmed: 15477635
Breast Cancer Res Treat. 2010 Apr;120(3):715-23
pubmed: 19669874
N Engl J Med. 2010 Jun 3;362(22):2053-65
pubmed: 20519679
J Reprod Med. 1993 Oct;38(10):781-90
pubmed: 8263867
Mol Clin Oncol. 2015 Mar;3(2):267-273
pubmed: 25798252
Nat Rev Clin Oncol. 2010 Dec;7(12):702-7
pubmed: 20956982
J Natl Cancer Inst. 2022 Feb 7;114(2):320-321
pubmed: 34424329
Arch Intern Med. 2011 Apr 25;171(8):760-8
pubmed: 21518944
Womens Health (Lond). 2009 Sep;5(5):565-76
pubmed: 19702455
Crit Rev Oncol Hematol. 2018 Dec;132:111-115
pubmed: 30447915
Obstet Gynecol. 2005 Jan;105(1):109-14
pubmed: 15625150
BMJ. 2014 Feb 11;348:g226
pubmed: 24519767
Breast Cancer Res Treat. 2012 Apr;132(3):1107-18
pubmed: 22207277
Obstet Gynecol. 2009 Jan;113(1):65-73
pubmed: 19104361
Breast Cancer Res. 2000;2(4):264-7
pubmed: 11250719
Curr Opin Obstet Gynecol. 2019 Dec;31(6):485-493
pubmed: 31609735
J Clin Oncol. 2011 Jun 10;29(17):2327-33
pubmed: 21537036
Clin Epidemiol. 2019 Jul 11;11:543-561
pubmed: 31372057
Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):654-8
pubmed: 17255289
JAMA Oncol. 2021 Aug 01;7(8):1203-1212
pubmed: 34081085
N Engl J Med. 2021 Feb 4;384(5):440-451
pubmed: 33471974
Breast Cancer Res. 2003;5(1):42-4
pubmed: 12559045
JAMA Oncol. 2015 Jun;1(3):296-305
pubmed: 26181174
Womens Health Rep (New Rochelle). 2020 Nov 26;1(1):521-528
pubmed: 33786518
Curr Oncol. 2022 Mar 21;29(3):2132-2140
pubmed: 35323372
BMC Cancer. 2015 Aug 19;15:593
pubmed: 26286255
Asia Pac J Clin Oncol. 2017 Feb;13(1):68-78
pubmed: 27230709
JAMA Oncol. 2016 Nov 01;2(11):1434-1440
pubmed: 27367496
Breast Cancer Res Treat. 2013 Jul;140(1):135-42
pubmed: 23784379
Nat Rev Clin Oncol. 2020 Nov;17(11):687-705
pubmed: 32555420
N Engl J Med. 2011 Jun 23;364(25):2381-91
pubmed: 21639806
Cancer Res Treat. 2018 Jul;50(3):917-925
pubmed: 29020732
J Natl Compr Canc Netw. 2021 Jan 06;19(1):77-102
pubmed: 33406487
Eur J Med Genet. 2021 Dec;64(12):104350
pubmed: 34606975
Eur J Cancer. 2007 Mar;43(5):867-76
pubmed: 17307353
PLoS One. 2015 Sep 18;10(9):e0136265
pubmed: 26383760
Int J Cancer. 2015 Feb 1;136(3):668-77
pubmed: 24947112
Ann Surg Oncol. 2021 Oct;28(10):5657-5662
pubmed: 34296361
Lancet. 2014 Mar 22;383(9922):1041-8
pubmed: 24333009
Value Health. 2021 Feb;24(2):303-312
pubmed: 33518037
Obstet Gynecol. 1993 Mar;81(3):357-62
pubmed: 8437786
Biomed Res Int. 2017;2017:6486859
pubmed: 29098159
J Clin Oncol. 2007 Nov 1;25(31):4868-72
pubmed: 17971581
Minerva Ginecol. 2019 Dec;71(6):395-403
pubmed: 32064823
Genet Med. 2021 Aug;23(8):1416-1423
pubmed: 33976419
BJOG. 2011 Jun;118(7):814-24
pubmed: 21392246
Eur J Contracept Reprod Health Care. 2022 Oct;27(5):373-383
pubmed: 35862627
Ann Surg Oncol. 2019 Jul;26(7):2127-2135
pubmed: 30815800
Gynecol Obstet Invest. 1992;34(2):97-101
pubmed: 1398273
Int J Behav Med. 2022 Feb;29(1):1-13
pubmed: 33791992
JAMA. 2018 Feb 13;319(6):595-606
pubmed: 29450530
Breast J. 2016 Jan-Feb;22(1):35-44
pubmed: 26695813
Br J Cancer. 2006 Mar 27;94(6):814-9
pubmed: 16495917
Breast J. 2016 Jan-Feb;22(1):10-7
pubmed: 26782950
BJOG. 2008 Nov;115(12):1473-83
pubmed: 19035986
Gynecol Oncol. 2016 Oct;143(1):113-119
pubmed: 27430397
Lancet. 1974 Oct 26;2(7887):983-5
pubmed: 4138830
Sci Rep. 2021 Feb 2;11(1):2847
pubmed: 33531640
J Clin Oncol. 2007 Sep 1;25(25):3985-90
pubmed: 17761984
Eur J Surg Oncol. 2008 Oct;34(10):1148-54
pubmed: 18434071
J Clin Oncol. 2009 Dec 10;27(35):5887-92
pubmed: 19858402
J Ovarian Res. 2020 May 2;13(1):50
pubmed: 32359370
Ann Surg Oncol. 2019 May;26(5):1254-1262
pubmed: 30830538
Acta Obstet Gynecol Scand. 1994 Aug;73(7):575-80
pubmed: 8079610
JAMA. 1999 Nov 24;282(20):1934-41
pubmed: 10580459
Can J Psychiatry. 1985 Feb;30(1):44-7
pubmed: 4038624
Int J Cancer. 2005 Apr 10;114(3):448-54
pubmed: 15551359
Cancer Epidemiol Biomarkers Prev. 2012 Jan;21(1):134-47
pubmed: 22144499
Gynecol Oncol. 2015 Feb;136(2):305-10
pubmed: 25560807
Am J Hum Genet. 2003 May;72(5):1117-30
pubmed: 12677558
Cancers (Basel). 2022 Mar 31;14(7):
pubmed: 35406563
Int J Cancer. 2014 May 1;134(9):2211-22
pubmed: 24127248
Lancet. 2003 Jan 25;361(9354):296-300
pubmed: 12559863
Ann Intern Med. 2014 Feb 18;160(4):255-66
pubmed: 24366442
Int J Gynaecol Obstet. 2011 Jun;113(3):222-4
pubmed: 21457974