Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future.
alternative treatment
chronic constipation
drug treatment
laxatives
magnesium salts
pharmacologic treatment
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
20 Feb 2023
20 Feb 2023
Historique:
received:
23
01
2023
revised:
14
02
2023
accepted:
17
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Despite great progress in pharmaceutical research, the medical treatment of chronic idiopathic constipation is far from ideal. The aim of the present article was to review literature data, focusing on poorly studied or commercially unavailable/unapproved drugs potentially useful for the treatment of chronic idiopathic constipation in adults. An extensive online literature search was conducted using the keywords "chronic constipation", "colon", "constipation", "drugs", "laxatives", and "treatment", in various combinations between January 1960 and December 2022. The literature search showed the presence of some drugs whose efficacy has only recently been demonstrated by modern investigations, and which are likely to be incorporated into future guidelines, of others that are proven effective and potentially effective on constipated patients but limited by small or relatively old studies, or by side effects which could be used in experienced hands, and of others that might be useful but lack a solid scientific background. Looking into the future for patients with chronic constipation might add some more tools to the therapeutic portfolio, especially for certain subgroups of these patients.
Identifiants
pubmed: 36836237
pii: jcm12041702
doi: 10.3390/jcm12041702
pmc: PMC9959210
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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