Impact of Female Gender in Inflammatory Bowel Diseases: A Narrative Review.
Crohn’s disease
female gender
female sex
inflammatory bowel disease
quality of life
ulcerative colitis
women
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
17 Jan 2023
17 Jan 2023
Historique:
received:
09
12
2022
revised:
05
01
2023
accepted:
12
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Inflammatory bowel diseases show a gender bias, as reported for several other immune-mediated diseases. Female-specific differences influence disease presentation and activity, leading to a different progression between males and females. Women show a genetic predisposition to develop inflammatory bowel disease related to the X chromosome. Female hormone fluctuation influences gastrointestinal symptoms, pain perception, and the state of active disease at the time of conception could negatively affect the pregnancy. Women with inflammatory bowel disease report a worse quality of life, higher psychological distress, and reduced sexual activity than male patients. This narrative review aims to resume the current knowledge of female-related features in clinical manifestations, development, and therapy, as well as sexual and psychological implications related to inflammatory bowel disease. The final attempt is to provide gastroenterologists with a roadmap of female-specific differences, to improve patients' diagnosis, management, and treatment.
Identifiants
pubmed: 36836400
pii: jpm13020165
doi: 10.3390/jpm13020165
pmc: PMC9958616
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : University of Ferarra
ID : FAR and FIR funds to RDG and G.C.
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