RNA Expression Signatures of Intracranial Aneurysm Growth Trajectory Identified in Circulating Whole Blood.
RNA-sequencing
aneurysm growth and rupture
classification
intracranial aneurysm
subarachnoid hemorrhage
transcriptomics
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
31 Jan 2023
31 Jan 2023
Historique:
received:
30
12
2022
revised:
24
01
2023
accepted:
27
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
After detection, identifying which intracranial aneurysms (IAs) will rupture is imperative. We hypothesized that RNA expression in circulating blood reflects IA growth rate as a surrogate of instability and rupture risk. To this end, we performed RNA sequencing on 66 blood samples from IA patients, for which we also calculated the predicted aneurysm trajectory (PAT), a metric quantifying an IA's future growth rate. We dichotomized dataset using the median PAT score into IAs that were either more stable and more likely to grow quickly. The dataset was then randomly divided into training (
Identifiants
pubmed: 36836499
pii: jpm13020266
doi: 10.3390/jpm13020266
pmc: PMC9967913
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL152270
Pays : United States
Organisme : UCLA
ID : Exploratory Research Grant
Organisme : National Institute of Health
ID : 1R01HL152270-01
Organisme : National Institute of Health
ID : 1 R43 NS115314-01
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