Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays.
cancer
cellular models
in vitro
metastasis
polyphenols
rheumatoid arthritis
signaling cascade
therapeutic adjuvant
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
28 Jan 2023
28 Jan 2023
Historique:
received:
23
12
2022
revised:
20
01
2023
accepted:
24
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Polyphenols have gained widespread attention as they are effective in the prevention and management of various diseases, including cancer diseases (CD) and rheumatoid arthritis (RA). They are natural organic substances present in fruits, vegetables, and spices. Polyphenols interact with various kinds of receptors and membranes. They modulate different signal cascades and interact with the enzymes responsible for CD and RA. These interactions involve cellular machinery, from cell membranes to major nuclear components, and provide information on their beneficial effects on health. These actions provide evidence for their pharmaceutical exploitation in the treatment of CD and RA. In this review, we discuss different pathways, modulated by polyphenols, which are involved in CD and RA. A search of the most recent relevant publications was carried out with the following criteria: publication date, 2012-2022; language, English; study design, in vitro; and the investigation of polyphenols present in extra virgin olive, grapes, and spices in the context of RA and CD, including, when available, the underlying molecular mechanisms. This review is valuable for clarifying the mechanisms of polyphenols targeting the pathways of senescence and leading to the development of CD and RA treatments. Herein, we focus on research reports that emphasize antioxidant properties.
Identifiants
pubmed: 36836717
pii: life13020361
doi: 10.3390/life13020361
pmc: PMC9967894
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Center 5 "National Biodiversity Future Center", theme "Bio-diversità", in the framework of the Piano Nazionale di Ripresa e Resilienza, Mission 4 Component 2 Investment 1.4, funded by the European Union -NextGenerationEU, identification code CN0
ID : CN00000033, CUP B73C21001300006
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