3D-Printed Soft Membrane for Periodontal Guided Tissue Regeneration.
3D-printed membrane
guided tissue regeneration (GTR)
membranes
periodontal
periodontal regeneration
tissue engineering
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
06 Feb 2023
06 Feb 2023
Historique:
received:
12
12
2022
revised:
24
01
2023
accepted:
28
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
The current study aimed to perform an in vivo examination using a critical-size periodontal canine model to investigate the capability of a 3D-printed soft membrane for guided tissue regeneration (GTR). This membrane is made of a specific composition of gelatin, elastin, and sodium hyaluronate that was fine-tuned and fully characterized in vitro in our previous study. The value of this composition is its potential to be employed as a suitable replacement for collagen, which is the main component of conventional GTR membranes, to overcome the cost issue with collagen. Critical-size dehiscence defects were surgically created on the buccal surface of the roots of canine bilateral mandibular teeth. GTR treatment was performed with the 3D-printed membrane and two commercially available collagen membranes (Botiss Jason Histometric evaluations confirmed higher levels of new bone formation in the 3D-printed membrane group. Moreover, in all defects treated with the membranes, the formation of periodontal tissues, bone, periodontal ligaments, and cementum was observed after 8 weeks, while in the control group, only connective tissue was found in the defect sites. There was no clinical sign of inflammation or recession of gingiva in any of the groups. The 3D-printed gelatin/elastin/sodium hyaluronate membrane can be safe and effective for use in GTR for periodontal tissue regeneration therapies, with better or comparable results to the commercial collagen membranes.
Identifiants
pubmed: 36836994
pii: ma16041364
doi: 10.3390/ma16041364
pmc: PMC9967512
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIDCR NIH HHS
ID : R15 DE027533
Pays : United States
Organisme : NIDCR NIH HHS
ID : R56 DE029191
Pays : United States
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