Natural Killer Cell Derived Microvesicles Affect the Function of Trophoblast Cells.
ERK1/2
STAT1
STAT3
microvesicles
migration
natural killer cells
proliferation
trophoblast
Journal
Membranes
ISSN: 2077-0375
Titre abrégé: Membranes (Basel)
Pays: Switzerland
ID NLM: 101577807
Informations de publication
Date de publication:
09 Feb 2023
09 Feb 2023
Historique:
received:
23
12
2022
revised:
02
02
2023
accepted:
06
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
The interaction of natural killer (NK) and trophoblast cells underlies the formation of immune tolerance in the mother-fetus system and the maintenance of the physiological course of pregnancy. In addition, NK cells affect the function of trophoblast cells, interacting with them via the receptor apparatus and through the production of cytokines. Microvesicles (MVs) derived from NK cells are able to change the function of target cells. However, in the overall pattern of interactions between NK cells and trophoblasts, the possibility that both can transmit signals to each other via MVs has not been taken into account. Therefore, the aim of this study was to assess the effect of NK cell-derived MVs on the phenotype, proliferation, and migration of trophoblast cells and their expression of intracellular messengers. We carried out assays for the detection of content transferred from MV to trophoblasts. We found that NK cell-derived MVs did not affect the expression of CD54, CD105, CD126, CD130, CD181, CD119, and CD120a receptors in trophoblast cells or lead to the appearance of CD45 and CD56 receptors in the trophoblast membrane. Further, the MVs reduced the proliferation but increased the migration of trophoblasts with no changes to their viability. Incubation of trophoblast cells in the presence of MVs resulted in the activation of STAT3 via pSTAT3(Ser727) but not via pSTAT3(Tyr705). The treatment of trophoblasts with MVs did not result in the phosphorylation of STAT1 and ERK1/2. The obtained data indicate that NK cell-derived MVs influence the function of trophoblast cells, which is accompanied by the activation of STAT3 signaling.
Identifiants
pubmed: 36837716
pii: membranes13020213
doi: 10.3390/membranes13020213
pmc: PMC9963951
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Russian Science Foundation
ID : 21-15-00021
Références
Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11520-5
pubmed: 9326642
J Immunol. 2020 Jul 1;205(1):153-167
pubmed: 32404352
Traffic. 2018 May;19(5):319-327
pubmed: 29479795
Nature. 2003 Oct 9;425(6958):577-84
pubmed: 14534577
J Thromb Haemost. 2014 Jul;12(7):1182-92
pubmed: 24818656
Eur J Immunol. 1997 Apr;27(4):979-83
pubmed: 9130653
Sci Rep. 2019 Jun 19;9(1):8756
pubmed: 31217484
Hum Reprod Update. 2012 Jul;18(4):458-71
pubmed: 22523109
Nat Commun. 2017 Dec 12;8(1):2079
pubmed: 29233981
Methods. 2015 Oct 1;87:64-74
pubmed: 25843788
Hum Reprod. 2006 Jan;21(1):193-201
pubmed: 16210392
Front Endocrinol (Lausanne). 2021 Jul 28;12:694885
pubmed: 34394001
J Extracell Vesicles. 2014 Aug 04;3:
pubmed: 25143819
Onco Targets Ther. 2021 Feb 25;14:1417-1427
pubmed: 33664576
J Immunol. 2019 May 15;202(10):3065-3075
pubmed: 30979816
Immunol Cell Biol. 2022 May;100(5):312-322
pubmed: 35233830
Exp Hematol. 1995 Dec;23(14):1642-8
pubmed: 8542959
Proc Natl Acad Sci U S A. 1997 May 13;94(10):5249-54
pubmed: 9144223
Blood. 2008 Sep 15;112(6):2327-35
pubmed: 18509085
Front Cell Dev Biol. 2020 Jun 26;8:415
pubmed: 32676501
J Leukoc Biol. 2016 Jun;99(6):857-62
pubmed: 26657511
Nat Rev Immunol. 2013 Feb;13(2):145-9
pubmed: 23348417
Nat Commun. 2020 Aug 26;11(1):4254
pubmed: 32848143
Trends Cell Biol. 2009 Feb;19(2):43-51
pubmed: 19144520
Cell Cycle. 2012 Jul 1;11(13):2427-30
pubmed: 22659845
Placenta. 2000 Mar-Apr;21 Suppl A:S81-5
pubmed: 10831129
Curr Mol Med. 2020;20(3):202-219
pubmed: 31393246
Circ Res. 2017 May 12;120(10):1658-1673
pubmed: 28495996
Mol Carcinog. 2016 May;55(5):499-513
pubmed: 25728212
Cancer Sci. 2007 May;98(5):621-8
pubmed: 17355265
Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118877
pubmed: 33007330
Biol Reprod. 2010 Feb;82(2):235-45
pubmed: 19571263
Eur J Appl Physiol. 2013 Apr;113(4):859-68
pubmed: 22990626
Am J Respir Cell Mol Biol. 2018 Jun;58(6):745-755
pubmed: 29361236
Anal Biochem. 1976 May 7;72:248-54
pubmed: 942051
Curr Biol. 2009 Dec 1;19(22):1875-85
pubmed: 19896381
Transl Res. 2016 Apr;170:112-123
pubmed: 25530473
J Circ Biomark. 2015 Jul 17;4:7
pubmed: 28936243
J Biol Chem. 2001 Mar 2;276(9):6133-9
pubmed: 11087747
Placenta. 2021 Feb;105:94-103
pubmed: 33556719
J Leukoc Biol. 2009 Dec;86(6):1319-29
pubmed: 19687291
J Biol Chem. 2020 May 8;295(19):6518-6531
pubmed: 32241914
Neurosci Bull. 2021 Mar;37(3):339-352
pubmed: 33196963
Am J Reprod Immunol. 2011 Oct;66(4):329-35
pubmed: 21385272
Bull Exp Biol Med. 2022 Mar;172(5):622-631
pubmed: 35352255
J Cell Physiol. 2022 Jan;237(1):59-85
pubmed: 34286853
Mol Cell Endocrinol. 2020 Mar 1;503:110699
pubmed: 31899258
J Immunol. 2012 Dec 1;189(11):5266-76
pubmed: 23125416
Trends Endocrinol Metab. 2021 Mar;32(3):170-189
pubmed: 33478870
Ther Adv Med Oncol. 2019 Dec 11;11:1758835919891622
pubmed: 31853267
J Immunol. 2006 Dec 15;177(12):8813-21
pubmed: 17142784
J Exp Med. 2022 May 2;219(5):
pubmed: 35404390
Cancer Lett. 2016 Sep 28;380(1):257-62
pubmed: 26523672
Blood. 2012 Mar 15;119(11):2500-9
pubmed: 22289892
Reprod Biol Endocrinol. 2022 Aug 13;20(1):120
pubmed: 35964080
Am J Pathol. 2013 May;182(5):1552-62
pubmed: 23499464
Front Immunol. 2021 Jun 07;12:676056
pubmed: 34163477
Bull Exp Biol Med. 2019 May;167(1):169-176
pubmed: 31183653
Cell Immunol. 2018 Feb;324:14-23
pubmed: 29198970
Genes Dis. 2022 Jan;9(1):12-27
pubmed: 34514075
Am J Transl Res. 2021 Nov 15;13(11):13135-13146
pubmed: 34956534
Am J Reprod Immunol. 2017 Aug;78(2):
pubmed: 28251711
Toxicol Sci. 2019 Jul 1;170(1):45-56
pubmed: 30912803
Front Immunol. 2018 Nov 05;9:2552
pubmed: 30455699
Reproduction. 2011 May;141(5):707-14
pubmed: 21310815
Blood. 2005 Sep 1;106(5):1604-11
pubmed: 15741221
J Hypertens. 2018 Nov;36(11):2215-2225
pubmed: 29939944
Int J Mol Sci. 2020 Dec 03;21(23):
pubmed: 33287465
J Control Release. 2017 Nov 28;266:100-108
pubmed: 28919558
Int J Cancer. 2015 Jan 15;136(2):462-75
pubmed: 24889539
Genes Dev. 2012 Jun 15;26(12):1287-99
pubmed: 22713869
J Cell Biol. 2013 Feb 18;200(4):373-83
pubmed: 23420871
Trends Cell Biol. 2015 Jun;25(6):364-72
pubmed: 25683921
Cytometry. 2002 Jul 1;48(3):146-52
pubmed: 12116360
Leukemia. 2020 Dec;34(12):3126-3135
pubmed: 32929129
Oncol Res. 1999;11(5):213-8
pubmed: 10608615
Eur J Obstet Gynecol Reprod Biol. 2011 Feb;154(2):151-6
pubmed: 21111525
Braz J Med Biol Res. 2013 Oct;46(10):824-30
pubmed: 24141609
Signal Transduct Target Ther. 2021 Mar 24;6(1):126
pubmed: 33758164
J Biol Chem. 2013 Jun 14;288(24):17713-24
pubmed: 23653359
Am J Reprod Immunol. 2016 Mar;75(3):341-50
pubmed: 26755153
Semin Cell Dev Biol. 2013 Mar;24(3):156-62
pubmed: 23270617
J Inflamm Res. 2021 May 25;14:2207-2223
pubmed: 34079328
BMC Immunol. 2021 Jan 6;22(1):3
pubmed: 33407095
Sci Rep. 2020 Apr 1;10(1):5785
pubmed: 32238853
J Clin Endocrinol Metab. 1971 May;32(5):683-7
pubmed: 5103722
Int J Mol Sci. 2021 Dec 20;22(24):
pubmed: 34948459
J Endocrinol. 2010 Oct;207(1):1-16
pubmed: 20817666
Sci Rep. 2017 Jul 4;7(1):4558
pubmed: 28676635
Curr Pharm Des. 2002;8(24):2131-7
pubmed: 12369858
J Thromb Haemost. 2006 Jun;4(6):1296-302
pubmed: 16706974
Curr Opin Immunol. 2015 Feb;32:71-7
pubmed: 25615701
Int J Mol Sci. 2016 Feb 06;17(2):170
pubmed: 26861301
Methods Mol Biol. 2008;484:79-93
pubmed: 18592174
Gynecol Endocrinol. 2019;35(sup1):35-40
pubmed: 31532312
Bull Exp Biol Med. 2018 Aug;165(4):564-571
pubmed: 30121912
Am J Pathol. 2008 May;172(5):1303-11
pubmed: 18403603
Mol Hum Reprod. 1997 Aug;3(8):655-62
pubmed: 9294848
Front Genet. 2019 Jan 30;10:12
pubmed: 30761180
Oncoimmunology. 2012 Sep 1;1(6):974-975
pubmed: 23162776
J Exp Clin Cancer Res. 2021 Oct 13;40(1):319
pubmed: 34645505
Am J Reprod Immunol. 2010 Mar 1;63(3):193-9
pubmed: 20047586
Proc Natl Acad Sci U S A. 2011 May 10;108(19):7820-5
pubmed: 21518866
Front Cell Neurosci. 2019 Aug 13;13:368
pubmed: 31456666
Sci Adv. 2018 Jan 31;4(1):eaar5701
pubmed: 29399633
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E968-77
pubmed: 26858453
Biol Reprod. 2016 Mar 9;94(5):106
pubmed: 26962115
Reprod Sci. 2018 Feb;25(2):185-197
pubmed: 28481180
ScientificWorldJournal. 2013 Oct 30;2013:259845
pubmed: 24288470
Reprod Biol Endocrinol. 2005 Oct 20;3:56
pubmed: 16236179
Adv Exp Med Biol. 2021;1302:41-50
pubmed: 34286440
J Exp Clin Cancer Res. 2021 Sep 18;40(1):291
pubmed: 34537073
J Exp Med. 2003 Jun 2;197(11):1585-98
pubmed: 12782720
Arch Med Res. 2015 May;46(4):245-56
pubmed: 26003221
Cell Metab. 2017 Jul 5;26(1):171-184.e6
pubmed: 28683285
Recent Prog Horm Res. 2003;58:263-81
pubmed: 12795423
Small GTPases. 2017 Oct 2;8(4):220-232
pubmed: 27494381
Int J Mol Sci. 2017 Mar 31;18(4):
pubmed: 28362325
Am J Reprod Immunol. 2014 Jul;72(1):65-74
pubmed: 24716848
Biochemistry (Mosc). 2019 Oct;84(10):1186-1196
pubmed: 31694514
Biol Reprod. 2006 May;74(5):896-904
pubmed: 16452465
Cancer Res. 2019 Oct 1;79(19):5088-5101
pubmed: 31416846
J Leukoc Biol. 2009 Jan;85(1):4-19
pubmed: 18784344
Int Immunopharmacol. 2017 Oct;51:124-130
pubmed: 28830025
Bull Exp Biol Med. 2020 Nov;170(1):123-127
pubmed: 33237529
Int J Gynecol Pathol. 2017 Jan;36(1):42-49
pubmed: 26937865
Cell Biol Int. 2019 Apr;43(4):394-401
pubmed: 30690788
Tsitologiia. 2005;47(5):393-403
pubmed: 16706143
J Exp Med. 1999 Apr 5;189(7):1093-100
pubmed: 10190900
Mol Biol Cell. 2013 May;24(9):1253-9
pubmed: 23630232
Int J Mol Sci. 2022 Feb 21;23(4):
pubmed: 35216502
Neural Plast. 2021 Feb 9;2021:6619515
pubmed: 33628219
Front Cell Dev Biol. 2021 Jan 12;8:620667
pubmed: 33511132
Immunobiology. 2021 Sep;226(5):152125
pubmed: 34365089
Hematol Oncol Stem Cell Ther. 2015 Jun;8(2):47-55
pubmed: 25571788
J Leukoc Biol. 1995 Aug;58(2):249-55
pubmed: 7543923
Eur J Nutr. 2021 Apr;60(3):1655-1668
pubmed: 32808060
Eur J Immunol. 2015 Jan;45(1):192-202
pubmed: 25308526
Immunol Lett. 2018 Apr;196:22-32
pubmed: 29366662
Mol Hum Reprod. 2007 Jul;13(7):511-9
pubmed: 17496316
Front Oncol. 2020 May 05;10:652
pubmed: 32432040
Oncotarget. 2017 Dec 1;8(70):115028-115040
pubmed: 29383139
J Immunol. 1998 May 15;160(10):4951-60
pubmed: 9590243
Oncotarget. 2016 Jun 14;7(24):36842-36853
pubmed: 27167205
Cold Spring Harb Protoc. 2016 Jul 01;2016(7):
pubmed: 27371595
Eur J Immunol. 2017 Sep;47(9):1535-1549
pubmed: 28665018
Biol Open. 2019 Jul 25;8(7):
pubmed: 31345790
Sci Signal. 2021 Nov 23;14(710):eabe4627
pubmed: 34813358
Cytokine Growth Factor Rev. 2013 Feb;24(1):41-9
pubmed: 22989616
Antiviral Res. 1993 Oct;22(2-3):91-105
pubmed: 7506512
Hum Reprod Update. 2007 Mar-Apr;13(2):121-41
pubmed: 17068222
Bull Exp Biol Med. 2020 Aug;169(4):586-595
pubmed: 32910391
Front Immunol. 2022 May 13;13:814019
pubmed: 35634345
Inflammation. 2014 Oct;37(5):1718-27
pubmed: 24854161
Semin Immunol. 2008 Dec;20(6):317-20
pubmed: 18656382
Endocrinology. 2009 Jan;150(1):350-6
pubmed: 18787030
J Immunotoxicol. 2016;13(1):27-37
pubmed: 25565016
Cytometry B Clin Cytom. 2017 Mar;92(2):100-114
pubmed: 28054442
Immunol Cell Biol. 2017 Sep;95(8):695-704
pubmed: 28653669
Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1477-87
pubmed: 22492089
Mol Hum Reprod. 2004 Feb;10(2):91-7
pubmed: 14742693
Cell Immunol. 2020 Jun;352:104110
pubmed: 32387976
Exp Cell Res. 2005 May 1;305(2):355-64
pubmed: 15817160