Serum Uric Acid Predicts All-Cause and Cardiovascular Mortality Independently of Hypertriglyceridemia in Cardiometabolic Patients without Established CV Disease: A Sub-Analysis of the URic acid Right for heArt Health (URRAH) Study.
cardiometabolic
cardiovascular
hypertriglyceridemia
mortality
risk prediction
serum uric acid
triglycerides
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
07 Feb 2023
07 Feb 2023
Historique:
received:
22
01
2023
revised:
02
02
2023
accepted:
06
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in the presence of normal and high TG levels has never been investigated. We included 8124 patients from the URic acid Right for heArt Health (URRAH) study cohort who were followed for over 20 years and had no established cardiovascular disease or uncontrolled metabolic disease. All-cause mortality (ACM) and cardiovascular mortality (CVM) were explored by the Kaplan-Meier estimator and Cox multivariable regression, adopting recently defined SUA cut-offs for ACM (≥4.7 mg/dL) and CVM (≥5.6 mg/dL). Exploratory analysis across cardiometabolic subgroups and a sensitivity analysis using SUA/serum creatinine were performed as validation. SUA predicted ACM (HR 1.25 [1.12-1.40],
Identifiants
pubmed: 36837863
pii: metabo13020244
doi: 10.3390/metabo13020244
pmc: PMC9959524
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Italian Society of Arterial Hypertension
ID : International Grant 2022
Références
J Cardiovasc Pharmacol. 2021 Dec 1;78(Suppl 6):S78-S87
pubmed: 34840260
J Hypertens. 2023 Jan 1;41(1):180-186
pubmed: 36453660
N Engl J Med. 2019 Dec 19;381(25):2440-2450
pubmed: 31851800
Lancet. 2018 Feb 10;391(10120):541-551
pubmed: 29221645
Postgrad Med J. 2020 Nov;96(1141):660-665
pubmed: 31911448
Hypertension. 2021 Feb;77(2):383-392
pubmed: 33356394
J Hypertens. 2022 Apr 1;40(4):704-711
pubmed: 34939996
Eur J Prev Cardiol. 2021 Feb 14;:
pubmed: 33582757
Intern Med J. 2021 Nov 15;:
pubmed: 34779574
Eur Heart J. 2021 Sep 7;42(34):3227-3337
pubmed: 34458905
Endocrine. 2020 Apr;68(1):71-80
pubmed: 31940133
Eur J Heart Fail. 2020 Nov;22(11):2093-2101
pubmed: 32840930
Diabetes Care. 2020 Jan;43(Suppl 1):S14-S31
pubmed: 31862745
J Hypertens. 2018 Sep;36(9):1840-1846
pubmed: 29916994
Eur Heart J. 2015 Mar 1;36(9):539-50
pubmed: 24474739
Am J Kidney Dis. 2010 Aug;56(2):273-88
pubmed: 20605302
Circulation. 2007 Aug 21;116(8):880-3
pubmed: 17709648
N Engl J Med. 2021 Nov 4;385(19):1737-1749
pubmed: 34554658
Dis Markers. 2022 Oct 15;2022:9927254
pubmed: 36284986
J Clin Hypertens (Greenwich). 2023 Jan;25(1):78-85
pubmed: 36573350
Nutr Metab Cardiovasc Dis. 2023 Feb;33(2):323-330
pubmed: 36642602
J Hypertens. 2021 Jan;39(1):62-69
pubmed: 32694342
J Clin Med. 2021 Oct 16;10(20):
pubmed: 34682873
J Am Heart Assoc. 2020 Apr 7;9(7):e013836
pubmed: 32200718
Hypertension. 2022 Sep;79(9):1927-1936
pubmed: 35658505
Front Cardiovasc Med. 2021 Sep 27;8:713652
pubmed: 34646871
J Physiol. 2016 Apr 15;594(8):2061-73
pubmed: 26391109
J Clin Med. 2020 Jun 28;9(7):
pubmed: 32605201
Eur Heart J. 2021 May 7;42(18):1742-1756
pubmed: 33748830
Nat Rev Cardiol. 2017 Oct;14(10):591-602
pubmed: 28492288
J Clin Med. 2019 Aug 12;8(8):
pubmed: 31408958
High Blood Press Cardiovasc Prev. 2022 Jan;29(1):41-48
pubmed: 34855153
Eur J Intern Med. 2020 Oct;80:1-11
pubmed: 32739239
Hypertens Res. 2012 Nov;35(11):1087-92
pubmed: 22739421
Atherosclerosis. 2013 Nov;231(1):61-8
pubmed: 24125412
Nutr Metab Cardiovasc Dis. 2022 Dec;32(12):2786-2793
pubmed: 36180296
Circ Res. 2022 Sep 2;131(6):476-491
pubmed: 35968712
J Hypertens. 2020 Mar;38(3):412-419
pubmed: 31644519
Nutrients. 2021 Nov 22;13(11):
pubmed: 34836431
Diabetes Obes Metab. 2020 Mar;22(3):279-289
pubmed: 31742844
J Am Soc Nephrol. 2015 Nov;26(11):2831-8
pubmed: 25788527
J Nephrol. 2022 Jan;35(1):211-221
pubmed: 33755930
Nat Rev Endocrinol. 2018 Oct;14(10):576-590
pubmed: 30046148
Lancet Diabetes Endocrinol. 2018 Sep;6(9):714-724
pubmed: 29859908
Immunol Rev. 2018 Jan;281(1):88-98
pubmed: 29247992
Clin Res Cardiol. 2021 Jul;110(7):1073-1082
pubmed: 33604722
Cardiovasc Diabetol. 2014 Dec 04;13:159
pubmed: 25471221
Sci Rep. 2018 Mar 27;8(1):5234
pubmed: 29588485
Nutr Metab Cardiovasc Dis. 2022 May;32(5):1245-1252
pubmed: 35282979
High Blood Press Cardiovasc Prev. 2018 Jun;25(2):197-202
pubmed: 29427170
Circ Res. 2012 Jul 20;111(3):278-89
pubmed: 22693349
Hypertension. 2020 Feb;75(2):302-308
pubmed: 31813345
Diabetologia. 2015 Mar;58(3):443-55
pubmed: 25481708
J Hum Hypertens. 2022 Nov;36(11):976-982
pubmed: 34588603