Gut Microbiota Composition Changes following Discontinuation of Exclusive Enteral Nutrition in Children with Crohn's Disease.
Crohn’s disease
adolescents
children
exclusive enteral nutrition
microbiota
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
17 Feb 2023
17 Feb 2023
Historique:
received:
13
12
2022
revised:
08
02
2023
accepted:
14
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
This study aims to determine changes in the intestinal microbiota of children with Crohn's disease (CD) before and during exclusive enteral nutrition (EEN) and after its discontinuation. A total of 14 newly diagnosed children with CD (median age 16.0 years; 43% female) were included in this study. Patients were initially treated with EEN and were followed for one year after EEN discontinuation. Stool samples were taken at the time of diagnosis (before EEN introduction), the second day of EEN, the last day of EEN, and every two months for one year after the discontinuation of EEN. A molecular approach targeting 16S ribosomal RNA was used for analysing the gut microbiota. No change was found in the Shannon diversity index before, during, and after EEN cessation (
Identifiants
pubmed: 36838471
pii: microorganisms11020505
doi: 10.3390/microorganisms11020505
pmc: PMC9960627
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Croatian Science Foundation
ID : IP-2014-09-3788
Références
J Crohns Colitis. 2020 Oct 07;:
pubmed: 33026087
Gut. 2017 Jan;66(1):194-195
pubmed: 26818618
Aliment Pharmacol Ther. 2013 Mar;37(6):622-9
pubmed: 23360085
Am J Gastroenterol. 2015 Dec;110(12):1718-29; quiz 1730
pubmed: 26526081
Dig Dis Sci. 2012 Aug;57(8):2171-7
pubmed: 22661250
J Crohns Colitis. 2013 May;7(4):263-70
pubmed: 22820027
Nutrients. 2020 Jun 05;12(6):
pubmed: 32517036
Inflamm Bowel Dis. 2020 Jun 18;26(7):1026-1037
pubmed: 31961432
Nutrients. 2020 Aug 23;12(9):
pubmed: 32842543
Inflamm Bowel Dis. 2016 Dec;22(12):2853-2862
pubmed: 27805918
Nutrients. 2017 May 01;9(5):
pubmed: 28468301
Gastroenterology. 2019 Apr;156(5):1354-1367.e6
pubmed: 30550821
Biomed Res Int. 2017;2017:8102589
pubmed: 29124070
J Pediatr Gastroenterol Nutr. 2020 Nov;71(5):589-595
pubmed: 33093364
JPEN J Parenter Enteral Nutr. 2021 Aug;45(6):1352-1363
pubmed: 32740959
Aliment Pharmacol Ther. 2008 Sep 15;28(6):724-33
pubmed: 19145728
Inflamm Bowel Dis. 2012 Jan;18(1):55-62
pubmed: 21351206
J Allergy Clin Immunol. 2016 Aug;138(2):592-6
pubmed: 26987574
Gastroenterology. 2019 Aug;157(2):440-450.e8
pubmed: 31170412
Inflamm Bowel Dis. 2011 Jun;17(6):1314-21
pubmed: 21560194
Sci Rep. 2020 Nov 3;10(1):18879
pubmed: 33144591
Curr Opin Clin Nutr Metab Care. 2017 Sep;20(5):384-389
pubmed: 28768295
Clin Transl Gastroenterol. 2015 Jan 15;6:e71
pubmed: 25588524
Cell Host Microbe. 2017 Aug 9;22(2):247
pubmed: 28799909
J Pediatr Gastroenterol Nutr. 2014 Jun;58(6):795-806
pubmed: 24231644
Aliment Pharmacol Ther. 2014 Jun;39(12):1398-407
pubmed: 24779671
Inflamm Bowel Dis. 2014 May;20(5):861-71
pubmed: 24651582
Dig Liver Dis. 2012 Sep;44(9):736-42
pubmed: 22622202