Hyaluronan-Cyclodextrin Conjugates as Doxorubicin Delivery Systems.
CD44
SK-N-SH
cyclodextrins
doxorubicin
hyaluronan-cyclodextrin conjugate
hyaluronic acid
nanomedicine
nanoparticles
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
21 Jan 2023
21 Jan 2023
Historique:
received:
20
12
2022
revised:
16
01
2023
accepted:
18
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
In the last years, nanoparticles based on cyclodextrins have been widely investigated for the delivery of anticancer drugs. In this work, we synthesized nanoparticles with a hyaluronic acid backbone functionalized with cyclodextrins under green conditions. We functionalized hyaluronic acid with two different molecular weights (about 11 kDa and 45 kDa) to compare their behavior as doxorubicin delivery systems. We found that the new hyaluronan-cyclodextrin conjugates increased the water solubility of doxorubicin. Moreover, we tested the antiproliferative activity of doxorubicin in the presence of the new cyclodextrin polymers in SK-N-SH and SK-N-SH-PMA (over-expressing CD44 receptor) cancer cells. We found that hyaluronan-cyclodextrin conjugates improved the uptake and antiproliferative activity of doxorubicin in the SK-N-SH-PMA compared to the SK-N-SH cell line at the ratio 8/1 doxorubicin/polymer. Notably, the system based on hyaluronan (45 kDa) was more effective as a drug carrier and significantly reduced the IC
Identifiants
pubmed: 36839696
pii: pharmaceutics15020374
doi: 10.3390/pharmaceutics15020374
pmc: PMC9963997
pii:
doi:
Types de publication
Journal Article
Langues
eng
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