Genetic Variation in
CYP2D6
SLC22A1
amlodipine
pharmacogenetics
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
25 Jan 2023
25 Jan 2023
Historique:
received:
04
01
2023
revised:
18
01
2023
accepted:
19
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Amlodipine is an antihypertensive drug with unknown pharmacogenetic biomarkers. This research is a candidate gene study that looked for associations between amlodipine pharmacokinetics and safety and pharmacogenes. Pharmacokinetic and safety data were taken from 160 volunteers from eight bioequivalence trials. In the exploratory step, 70 volunteers were genotyped for 44 polymorphisms in different pharmacogenes. CYP2D6 poor metabolizers (PMs) showed higher half-life (t
Identifiants
pubmed: 36839726
pii: pharmaceutics15020404
doi: 10.3390/pharmaceutics15020404
pmc: PMC9959242
pii:
doi:
Types de publication
Journal Article
Langues
eng
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