Polymer-Antimicrobial Peptide Constructs with Tailored Drug-Release Behavior.
HPMA copolymers
antimicrobial peptides
bacteria
drug delivery
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
25 Jan 2023
25 Jan 2023
Historique:
received:
15
12
2022
revised:
20
01
2023
accepted:
23
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Microbial resistance is one of the main problems of modern medicine. Recently, antimicrobial peptides have been recognized as a novel approach to overcome the microbial resistance issue, nevertheless, their low stability, toxicity, and potential immunogenic response in biological systems have limited their clinical application. Herein, we present the design, synthesis, and preliminary biological evaluation of polymer-antibacterial peptide constructs. The antimicrobial GKWMKLLKKILK-NH
Identifiants
pubmed: 36839728
pii: pharmaceutics15020406
doi: 10.3390/pharmaceutics15020406
pmc: PMC9960778
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Czech Science Foundation
ID : 20-04790S
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