Development and Comparative In Vitro and In Vivo Study of BNN27 Mucoadhesive Liposomes and Nanoemulsions for Nose-to-Brain Delivery.
BNN27
LIPs
chitosan
intranasal delivery
mucoadhesive formulations
nanoemulsions
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
27 Jan 2023
27 Jan 2023
Historique:
received:
05
01
2023
revised:
20
01
2023
accepted:
24
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
Intranasal administration offers an alternative and promising approach for direct nose-to-brain delivery. Herein, we developed two chitosan (CHT)-coated (and uncoated) nanoformulations of BNN27 (a synthetic C-17-spiro-dehydroepiandrosterone analogue), liposomes (LIPs), and nanoemulsions (NEs), and compared their properties and brain disposition (in vitro and in vivo). LIPs were formulated by thin film hydration and coated with CHT by dropwise addition. BNN27-loaded NEs (BNEs) were developed by spontaneous emulsification and optimized for stability and mucoadhesive properties. Mucoadhesive properties were evaluated by mucin adherence. Negatively charged CHT-coated LIPs (with 0.1% CHT/lipid) demonstrated the highest coating efficiency and mucoadhesion. BNEs containing 10%
Identifiants
pubmed: 36839740
pii: pharmaceutics15020419
doi: 10.3390/pharmaceutics15020419
pmc: PMC9967044
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : the European Regional Development Fund of the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH-CREATE-INNOVATE (project code: T1EDK-03186, Acronym: DINNESMIN
ID : T1EDK-03186
Références
Pharmaceutics. 2020 Jul 17;12(7):
pubmed: 32709076
Eur J Pharm Sci. 2000 Jul;11(1):1-18
pubmed: 10913748
Anal Biochem. 1976 May 7;72:248-54
pubmed: 942051
J Pharm Sci. 2020 Jul;109(7):2237-2251
pubmed: 32320670
Drug Dev Ind Pharm. 2019 Jul;45(7):1061-1072
pubmed: 30922126
Pharm Res. 2014 May;31(5):1275-89
pubmed: 24338512
Clin Chem. 1973 Dec;19(12):1350-6
pubmed: 4757363
Trends Endocrinol Metab. 2008 Oct;19(8):300-7
pubmed: 18771935
J Microencapsul. 2001 Jan-Feb;18(1):3-12
pubmed: 11201339
J Pharm Sci. 2010 Apr;99(4):1654-73
pubmed: 19877171
Pharm Res. 2017 Jul;34(7):1416-1427
pubmed: 28389708
Biochem Pharmacol. 2016 Oct 1;117:68-77
pubmed: 27498123
Int J Pharm. 2017 Aug 30;529(1-2):667-677
pubmed: 28729175
J Control Release. 2018 Jul 10;281:139-177
pubmed: 29772289
Pharmacol Res Perspect. 2021 Apr;9(2):e00724
pubmed: 33638308
Int J Pharm. 2008 Apr 16;354(1-2):204-9
pubmed: 18207675
Anal Biochem. 1980 May 1;104(1):10-4
pubmed: 6892980
Drug Dev Ind Pharm. 2009 Mar;35(3):379-86
pubmed: 18951272
Eur J Pharm Biopharm. 2020 Jul;152:248-256
pubmed: 32439308
AAPS PharmSciTech. 2017 Apr;18(3):686-696
pubmed: 27207184
Eur J Pharm Biopharm. 2012 May;81(1):49-56
pubmed: 22386910
J Control Release. 2003 Jan 17;86(2-3):235-42
pubmed: 12526820
Oncotarget. 2017 Feb 7;8(6):9005-9006
pubmed: 28099949
J Neurochem. 2008 Dec;107(5):1358-68
pubmed: 19013850
J Med Chem. 2009 Nov 12;52(21):6569-87
pubmed: 19845386
J Vis Exp. 2018 Nov 14;(141):
pubmed: 30507914
Springerplus. 2015 Jun 12;4(Suppl 1):L25
pubmed: 27386188
Int J Biol Macromol. 2016 Jul;88:320-32
pubmed: 26976069
Clin Chem. 1974 Apr;20(4):470-5
pubmed: 4818200
Nanoscale. 2017 Jan 19;9(3):1174-1183
pubmed: 28009915
Drug Dev Ind Pharm. 2009 Apr;35(4):387-95
pubmed: 19016058
Eur J Pharm Biopharm. 2018 Jul;128:337-362
pubmed: 29733950
Expert Opin Drug Deliv. 2018 Apr;15(4):369-378
pubmed: 29338427
Adv Sci (Weinh). 2017 Jan 31;4(5):1600476
pubmed: 28546914
Psychopharmacology (Berl). 2020 Aug;237(8):2435-2449
pubmed: 32506234
Adv Healthc Mater. 2022 Jun;11(11):e2102610
pubmed: 35166052
Int J Pharm. 2000 Feb 25;196(1):51-61
pubmed: 10675707
Pharmaceutics. 2019 Feb 17;11(2):
pubmed: 30781585
Drug Dev Ind Pharm. 2011 Apr;37(4):482-8
pubmed: 20961263
Int J Pharm. 2008 Jun 24;358(1-2):285-91
pubmed: 18455333
Colloids Surf B Biointerfaces. 2009 Jun 1;71(1):88-95
pubmed: 19201583
Int J Pharm. 2014 Oct 1;473(1-2):591-8
pubmed: 25102113