Low-Level Laser Treatment Induces the Blood-Brain Barrier Opening and the Brain Drainage System Activation: Delivery of Liposomes into Mouse Glioblastoma.
blood-brain barrier
brain drainage system
glioblastoma
infrared low-intensity laser treatment
liposomes
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
08 Feb 2023
08 Feb 2023
Historique:
received:
16
01
2023
revised:
30
01
2023
accepted:
02
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
26
2
2023
Statut:
epublish
Résumé
The progress in brain diseases treatment is limited by the blood-brain barrier (BBB), which prevents delivery of the vast majority of drugs from the blood into the brain. In this study, we discover unknown phenomenon of opening of the BBBB (BBBO) by low-level laser treatment (LLLT, 1268 nm) in the mouse cortex. LLLT-BBBO is accompanied by activation of the brain drainage system contributing effective delivery of liposomes into glioblastoma (GBM). The LLLT induces the generation of singlet oxygen without photosensitizers (PSs) in the blood endothelial cells and astrocytes, which can be a trigger mechanism of BBBO. LLLT-BBBO causes activation of the ABC-transport system with a temporal decrease in the expression of tight junction proteins. The BBB recovery is accompanied by activation of neuronal metabolic activity and stabilization of the BBB permeability. LLLT-BBBO can be used as a new opportunity of interstitial PS-free photodynamic therapy (PDT) for modulation of brain tumor immunity and improvement of immuno-therapy for GBM in infants in whom PDT with PSs, radio- and chemotherapy are strongly limited, as well as in adults with a high allergic reaction to PSs.
Identifiants
pubmed: 36839889
pii: pharmaceutics15020567
doi: 10.3390/pharmaceutics15020567
pmc: PMC9966329
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : EU's H2020 FET OPEN NEUROPA
ID : 863214
Organisme : Grant from the Russian Ministry of Science and High Education
ID : 075-15-2022-1094
Organisme : NIGMS NIH HHS
ID : P20 GM109089
Pays : United States
Organisme : NIH HHS
ID : R21NS091600 and R01 NS112808
Pays : United States
Organisme : Russian Science Foundation
ID : 21-75-10088; 23-25-00296; 21-74-20177
Organisme : NINDS NIH HHS
ID : R01 NS112808
Pays : United States
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