Effects of aluminium chloride added to common patch test substances.
adjuvants
allergic contact dermatitis
irritants
mixes with aluminium
patch testing with metals
sensitivity
specificity
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
revised:
09
02
2023
received:
21
10
2022
accepted:
13
02
2023
medline:
8
5
2023
pubmed:
26
2
2023
entrez:
25
2
2023
Statut:
ppublish
Résumé
A modulating effect of aluminium regarding type IV reactions might exist but has not been further investigated. The aim of this study was to investigate the effect on patch test reactions when adding aluminium chloride hexahydrate (Al-Cl) to common test preparations. Al-Cl in different concentrations was added to nickel sulphate 15.0% aqua (Ni), methylisothiazolinone 0.2% aqua (MI) and fragrance mix I 10.0% aqua/ethanol (FM I). The Ni preparations were tested in 120 consecutive patients. MI and FM I were tested in participants known to have contact allergy to the respective allergen. McNemar's test was used to decide which Ni preparation had the highest sensitivity. Wilcoxon signed-rank test was used to calculate pairwise comparison in summarized test score for the preparations with MI and FM I. Adding Al-Cl 20.0%/30.0% to Ni identified twice as many patients with contact allergy to nickel compared to Ni without Al-Cl. Adding Al-Cl 20.0%/10.0% to MI, decreased the patch test reactivity compared to MI without Al-Cl. No differences in patch reactivity were noticed when adding Al-Cl to FM I. Al-Cl 20.0% or 30.0% seems to enhance the patch test reactivity to Ni 15.0% aqua.
Sections du résumé
BACKGROUND
BACKGROUND
A modulating effect of aluminium regarding type IV reactions might exist but has not been further investigated.
OBJECTIVES
OBJECTIVE
The aim of this study was to investigate the effect on patch test reactions when adding aluminium chloride hexahydrate (Al-Cl) to common test preparations.
MATERIALS AND METHODS
METHODS
Al-Cl in different concentrations was added to nickel sulphate 15.0% aqua (Ni), methylisothiazolinone 0.2% aqua (MI) and fragrance mix I 10.0% aqua/ethanol (FM I). The Ni preparations were tested in 120 consecutive patients. MI and FM I were tested in participants known to have contact allergy to the respective allergen. McNemar's test was used to decide which Ni preparation had the highest sensitivity. Wilcoxon signed-rank test was used to calculate pairwise comparison in summarized test score for the preparations with MI and FM I.
RESULTS
RESULTS
Adding Al-Cl 20.0%/30.0% to Ni identified twice as many patients with contact allergy to nickel compared to Ni without Al-Cl. Adding Al-Cl 20.0%/10.0% to MI, decreased the patch test reactivity compared to MI without Al-Cl. No differences in patch reactivity were noticed when adding Al-Cl to FM I.
CONCLUSION
CONCLUSIONS
Al-Cl 20.0% or 30.0% seems to enhance the patch test reactivity to Ni 15.0% aqua.
Substances chimiques
Aluminum Chloride
3CYT62D3GA
Allergens
0
Aluminum
CPD4NFA903
2-methyl-4-isothiazolin-3-one
229D0E1QFA
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
456-462Subventions
Organisme : Astma- och Allergiförbundet
Informations de copyright
© 2023 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
Références
Johansen JD, Aalto-Korte K, Agner T, et al. European Society of Contact Dermatitis guideline for diagnostic patch testing - recommendations on best practice. Contact Dermatitis. 2015;73(4):195-221.
Ponten A, Goossens A, Bruze M. Recommendation to include formaldehyde 2.0% aqua in the European baseline patch test series. Contact Dermatitis. 2013;69(6):372-374.
Bruze M, Engfeldt M, Goncalo M, Goossens A. Recommendation to include methylisothiazolinone in the European baseline patch test series - on behalf of the European Society of Contact Dermatitis and the European Environmental and Contact Dermatitis Research Group. Contact Dermatitis. 2013;69(5):263-270.
Isaksson M, Ryberg K, Goossens A, Bruze M. Recommendation to include a textile dye mix in the European baseline series. Contact Dermatitis. 2015;73(1):15-20.
Agner T, Johansen JD, Overgaard L, Volund A, Basketter D, Menne T. Combined effects of irritants and allergens. Synergistic effects of nickel and sodium lauryl sulfate in nickel-sensitized individuals. Contact Dermatitis. 2002;47(1):21-26.
Kligman AM. The SLS provocative patch test in allergic contact sensitization. J Invest Dermatol. 1966;46(6):573-583.
Seidenari S, Manzini BM, Belletti B. Pretreatment of the test area with 1-day occlusion improves the response rate to NiSO4 5% pet. patch tests in subjects with a positive history of nickel allergy. Contact Dermatitis. 1995;33(3):152-156.
Seidenari S, Motolese A, Belletti B. Pre-treatment of nickel test areas with sodium lauryl sulfate detects nickel sensitivity in subjects reacting negatively to routinely performed patch tests. Contact Dermatitis. 1996;34(2):88-92.
Dickel H, Kreft B, Kuss O, et al. Increased sensitivity of patch testing by standardized tape stripping beforehand: a multicentre diagnostic accuracy study. Contact Dermatitis. 2010;62(5):294-302.
Garcon N, Hem S, Friede M. 5-Evolution of adjuvants across the centuries. Vaccines. 6th ed. Elsievier; 2013.
Siemund I, Hindsen M, Netterlid E, Guner N, Bruze M. Contact allergy in atopic individuals in relation to allergen-specific immunotherapy. Eur J Dermatol. 2016;26(3):271-280.
Siemund I, Zimerson E, Hindsen M, Bruze M. Establishing aluminium contact allergy. Contact Dermatitis. 2012;67(3):162-170.
Bruze M, Hindsen M, Mowitz M. A retrospective study of aimed patch testing with aqueous nickel sulfate hexahydrate at 30% and 15% in patients with dermatitis. Dermatitis. 2018;29(4):193-195.
Fregert S. Manual of Contact Dermatitis. 2nd ed. Munksgaard; 1981.
Hindsen M, Bruze M, Christensen OB. Individual variation in nickel patch test reactivity. Am J Contact Dermat. 1999;10(2):62-67.
Bonefeld CM, Geisler C, Gimenez-Arnau E, Lepoittevin JP, Uter W, Johansen JD. Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens. Contact Dermatitis. 2017;77(3):133-142.
Johansen JD, Skov L, Volund A, Andersen K, Menne T. Allergens in combination have a synergistic effect on the elicitation response: a study of fragrance-sensitized individuals. Br J Dermatol. 1998;139(2):264-270.
McLelland J, Shuster S. Contact dermatitis with negative patch tests: the additive effect of allergens in combination. Br J Dermatol. 1990;122(5):623-630.
Krasteva M, Garrigue JL, Horrand F, Tchou I, Descotes J, Nicolas JF. Suboptimal non-inflammatory concentrations of haptens may elicit a contact sensitivity reaction when used as a mix. Contact Dermatitis. 1996;35(5):279-282.
McLelland J, Shuster S, Matthews JN. 'Irritants' increase the response to an allergen in allergic contact dermatitis. Arch Dermatol. 1991;127(7):1016-1019.
Allenby CF, Basketter DA. An arm immersion model of compromised skin (II). Influence on minimal eliciting patch test concentrations of nickel. Contact Dermatitis. 1993;28(3):129-133.
Wilkinson M, Goncalo M, Aerts O, et al. The European baseline series and recommended additions: 2019. Contact Dermatitis. 2019;80(1):1-4.
Liden C, Skare L, Lind B, Nise G, Vahter M. Assessment of skin exposure to nickel, chromium and cobalt by acid wipe sampling and ICP-MS. Contact Dermatitis. 2006;54(5):233-238.
Fullerton A, Andersen JR, Hoelgaard A, Menne T. Permeation of nickel salts through human skin in vitro. Contact Dermatitis. 1986;15(3):173-177.
Rasanen L, Mattila U, Kalimo K. Patch testing with nickel sulfate versus nickel chloride. Contact Dermatitis. 1999;40(5):287-288.
Nikpour S, Hedberg YS. Using chemical speciation modelling to discuss variations in patch test reactions to different aluminium and chromium salts. Contact Dermatitis. 2021;85(4):415-420.
Hedberg YS, Dobryden I, Chaudhary H, Wei Z, Claesson PM, Lendel C. Synergistic effects of metal-induced aggregation of human serum albumin. Colloids Surf B Biointerfaces. 2019;173:751-758.