Aerobic exercise and scaffolds with hierarchical porosity synergistically promote functional recovery post volumetric muscle loss.
Colloidal scaffolds
Exercise therapy
IGF-1
In situ printing
Volumetric muscle loss
Journal
Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
03
07
2022
revised:
10
01
2023
accepted:
14
02
2023
pmc-release:
01
05
2024
medline:
11
4
2023
pubmed:
26
2
2023
entrez:
25
2
2023
Statut:
ppublish
Résumé
Volumetric muscle loss (VML), which refers to a composite skeletal muscle defect, most commonly heals by scarring and minimal muscle regeneration but substantial fibrosis. Current surgical interventions and physical therapy techniques are limited in restoring muscle function following VML. Novel tissue engineering strategies may offer an option to promote functional muscle recovery. The present study evaluates a colloidal scaffold with hierarchical porosity and controlled mechanical properties for the treatment of VML. In addition, as VML results in an acute decrease in insulin-like growth factor 1 (IGF-1), a myogenic factor, the scaffold was designed to slowly release IGF-1 following implantation. The foam-like scaffold is directly crosslinked onto remnant muscle without the need for suturing. In situ 3D printing of IGF-1-releasing porous muscle scaffold onto VML injuries resulted in robust tissue ingrowth, improved muscle repair, and increased muscle strength in a murine VML model. Histological analysis confirmed regeneration of new muscle in the engineered scaffolds. In addition, the scaffolds significantly reduced fibrosis and increased the expression of neuromuscular junctions in the newly regenerated tissue. Exercise training, when combined with the engineered scaffolds, augmented the treatment outcome in a synergistic fashion. These data suggest highly porous scaffolds and exercise therapy, in combination, may be a treatment option following VML.
Identifiants
pubmed: 36841214
pii: S0142-9612(23)00066-2
doi: 10.1016/j.biomaterials.2023.122058
pmc: PMC10085854
mid: NIHMS1877814
pii:
doi:
Substances chimiques
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
122058Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR073822
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR077132
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR079114
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Mohamadmahdi Samandari reports a relationship with InPrint Bio LLC that includes: equity or stocks. Jacob Quint reports a relationship with InPrint Bio LLC that includes: equity or stocks. Ali Tamayol reports a relationship with InPrint Bio LLC that includes: equity or stocks. Indranil Sinha reports a relationship with InPrint Bio LLC that includes: equity or stocks.
Références
Trends Biotechnol. 2020 Apr;38(4):418-431
pubmed: 31699534
Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H326-36
pubmed: 26608338
Tissue Eng Part B Rev. 2019 Dec;25(6):510-525
pubmed: 31578930
J Clin Endocrinol Metab. 1996 Oct;81(10):3492-7
pubmed: 8855791
Adv Mater. 2022 Mar;34(12):e2105883
pubmed: 34773667
Front Physiol. 2020 Jul 23;11:874
pubmed: 32792984
Bioact Mater. 2021 Jul 05;8:296-308
pubmed: 34541402
Biofabrication. 2017 Feb 14;9(1):015020
pubmed: 28195834
Nat Mater. 2015 Jul;14(7):737-44
pubmed: 26030305
Am J Sports Med. 2005 May;33(5):745-64
pubmed: 15851777
Sci Adv. 2019 Mar 20;5(3):eaav1281
pubmed: 30906864
Adv Healthc Mater. 2020 May;9(9):e1901058
pubmed: 32196144
Appl Phys Rev. 2021 Dec;8(4):041415
pubmed: 34970378
J Orthop Res. 2015 Jan;33(1):40-6
pubmed: 25231205
Plast Reconstr Surg. 2007 Jun;119(7):2118-2126
pubmed: 17519710
Adv Healthc Mater. 2021 May;10(10):e2002152
pubmed: 33644996
Growth Horm IGF Res. 2014 Oct;24(5):157-63
pubmed: 25002025
Exerc Sport Sci Rev. 1998;26:31-60
pubmed: 9696984
Nat Rev Mol Cell Biol. 2011 Dec 21;13(2):127-33
pubmed: 22186952
Clin Endocrinol (Oxf). 1998 Dec;49(6):739-46
pubmed: 10209561
Small. 2019 Jun;15(24):e1805530
pubmed: 31012262
Nat Biotechnol. 2014 Aug;32(8):773-85
pubmed: 25093879
Wound Repair Regen. 2017 May;25(3):408-413
pubmed: 28494512
Biofabrication. 2016 Sep 16;8(3):035020
pubmed: 27634915
Clin Endocrinol (Oxf). 1999 Jun;50(6):683-9
pubmed: 10468938
Discoveries (Craiova). 2019 Mar 31;7(1):e90
pubmed: 32309608
Sci Rep. 2019 May 22;9(1):7733
pubmed: 31118478
Sci Rep. 2019 Feb 12;9(1):1856
pubmed: 30755653
Nat Commun. 2017 Jun 20;8:15613
pubmed: 28631758
FASEB J. 2020 Dec;34(12):16086-16104
pubmed: 33064329
Nanoscale. 2022 Jan 20;14(3):797-814
pubmed: 34951427
Nat Commun. 2021 Jan 29;12(1):692
pubmed: 33514709
Clin Plast Surg. 2002 Oct;29(4):483-95, v-vi
pubmed: 12484600
Plast Reconstr Surg. 2008 Jun;121(6):2010-2019
pubmed: 18520889
Adv Mater. 2017 Aug;29(32):
pubmed: 28650574
Nat Mater. 2015 Dec;14(12):1269-77
pubmed: 26366848
Tissue Eng Part C Methods. 2019 Feb;25(2):59-70
pubmed: 30648479
Cell. 2006 Aug 25;126(4):677-89
pubmed: 16923388
BMC Sports Sci Med Rehabil. 2014 Dec 19;6(1):41
pubmed: 25598983
Am J Physiol Regul Integr Comp Physiol. 2010 May;298(5):R1173-87
pubmed: 20219869
Trends Cell Biol. 2011 Sep;21(9):543-51
pubmed: 21727007
Sci Rep. 2018 Aug 17;8(1):12307
pubmed: 30120282
Nanoscale. 2019 Aug 29;11(34):15846-15861
pubmed: 31289795
Cells. 2020 Jul 24;9(8):
pubmed: 32722232
Adv Healthc Mater. 2020 Jan;9(1):e1900626
pubmed: 31622051
J R Soc Interface. 2011 Feb 6;8(55):153-70
pubmed: 20719768
J Cell Biol. 2004 Sep 13;166(6):877-87
pubmed: 15364962
Acta Biomater. 2015 Oct;25:2-15
pubmed: 26219862
Tissue Eng Part A. 2009 Jul;15(7):1695-707
pubmed: 19119921
Sci Transl Med. 2014 Apr 30;6(234):234ra58
pubmed: 24786326
Sci Rep. 2017 Oct 13;7(1):13179
pubmed: 29030619
FASEB J. 2004 Feb;18(2):403-5
pubmed: 14688207
J Mater Sci Mater Med. 2021 Jan 21;32(1):15
pubmed: 33475855
Appl Phys Rev. 2021 Jun;8(2):021404
pubmed: 34084254
PLoS One. 2021 Jun 25;16(6):e0253629
pubmed: 34170933
Adv Healthc Mater. 2015 Dec 9;4(17):2677-87
pubmed: 26474318
J Am Acad Orthop Surg. 2011;19 Suppl 1:S35-7
pubmed: 21304045
J Rehabil Res Dev. 2015;52(7):785-92
pubmed: 26745661
Nat Commun. 2020 Feb 24;11(1):1025
pubmed: 32094341
Acta Biomater. 2021 Jun;127:313-326
pubmed: 33705990
BMC Musculoskelet Disord. 2018 May 29;19(1):173
pubmed: 29843673
Acta Biomater. 2020 Jan 1;101:14-25
pubmed: 31476384
Adv Colloid Interface Sci. 2004 May 20;108-109:63-71
pubmed: 15072929
Adv Mater. 2011 Mar 25;23(12):H119-24
pubmed: 21394793
In Vivo. 2009 Sep-Oct;23(5):779-96
pubmed: 19779115
Wound Repair Regen. 2020 Jan;28(1):61-74
pubmed: 31603580
Proc Natl Acad Sci U S A. 2019 May 21;116(21):10244-10249
pubmed: 31068458
Biomaterials. 2017 Sep;140:115-127
pubmed: 28646685
ACS Appl Bio Mater. 2020 Mar 16;3(3):1568-1579
pubmed: 35021647
Nat Rev Immunol. 2017 Mar;17(3):165-178
pubmed: 28163303
Tissue Eng Part C Methods. 2010 Dec;16(6):1439-48
pubmed: 20388039