Wnt signalling in the articular cartilage: A matter of balance.
Wnt
articular cartilage
osteoarthritis
Journal
International journal of experimental pathology
ISSN: 1365-2613
Titre abrégé: Int J Exp Pathol
Pays: England
ID NLM: 9014042
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
revised:
30
01
2023
received:
10
08
2022
accepted:
04
02
2023
pubmed:
28
2
2023
medline:
15
3
2023
entrez:
27
2
2023
Statut:
ppublish
Résumé
Degradation of the articular cartilage is a hallmark of osteoarthritis, a progressive and chronic musculoskeletal condition, affecting millions of people worldwide. The activation of several signalling cascades is altered during disease development: among them, the Wnt signalling plays a pivotal role in the maintenance of tissue homeostasis. Increasing evidence is showing that its activation needs to be maintained within a certain range to avoid the triggering of degenerative mechanisms. In this review, we summarise our current knowledge about how a balanced activation of the Wnt signalling is maintained in the articular cartilage, with a particular focus on receptor-mediated mechanisms.
Identifiants
pubmed: 36843204
doi: 10.1111/iep.12472
pmc: PMC10009303
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
56-63Subventions
Organisme : Medical Research Council
ID : MR/S008608/1
Pays : United Kingdom
Informations de copyright
© 2023 The Authors. International Journal of Experimental Pathology published by John Wiley & Sons Ltd on behalf of Company of the International Journal of Experimental Pathology (CIJEP).
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