Pharmacokinetics and Pharmacodynamics of Anthocyanins after Administration of Tart Cherry Juice to Individuals with Gout.
anthocyanins
gout
inflammation
pharmacokinetics
tart cherry
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
revised:
21
12
2022
received:
18
08
2022
medline:
10
5
2023
pubmed:
28
2
2023
entrez:
27
2
2023
Statut:
ppublish
Résumé
Tart cherries (TCs) contain high levels of anthocyanins that exert potent antioxidant and antiinflammatory effects and potentially benefit individuals with gout. This study aims to quantitate the major anthocyanins in TC Juice Concentrate (TCJC) and identify the pharmacokinetic (PK) and pharmacodynamic (PD) parameters of the major anthocyanin cyanidin-3-glucosylrutinoside (C3GR). A PK-PD study enrolling human subjects with a history of gout is performed. Subjects are randomized to receive either 60 or 120 mL of TCJC. Anthocyanins are quantitated using liquid chromatography-mass spectroscopy (LCMS). Antioxidant and antiinflammatory mRNA expression is measured using real-time qPCR before and after the administration of TCJC. A population PK model (popPK) is fit to the experimental data, and an indirect PD model (IDR) is constructed in Monolix. Of the bioavailable anthocyanins, C3GR achieves the highest plasma concentration in a dose-dependent manner. A popPK predicts anthocyanin exposure, and an IDR produces reasonable approximations of PD effects.
Identifiants
pubmed: 36843307
doi: 10.1002/mnfr.202200550
doi:
Substances chimiques
Antioxidants
0
Anthocyanins
0
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200550Informations de copyright
© 2023 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.
Références
A. Wertheimer, R. Morlock, M. A. Becker, Curr. Ther. Res. Clin. Exp. 2013, 75, 1.
J. Coresh, B. C. Astor, T. Greene, G. Eknoyan, A. S. Levey, Am. J. Kidney Dis. 2003, 41, 1.
Writing Group Members, D. Mozaffarian, E. J. Benjamin, A. S. Go, D. K. Arnett, M. J. Blaha, M. Cushman, S. R. Das, S. de Ferranti, J.-P. Després, H. J. Fullerton, V. J. Howard, M. D. Huffman, C. R. Isasi, M. C. Jiménez, S. E. Judd, B. M. Kissela, J. H. Lichtman, L. D. Lisabeth, S. Liu, R. H. Mackey, D. J. Magid, D. K. McGuire, E. R. Mohler 3rd, C. S. Moy, P. Muntner, M. E. Mussolino, K. Nasir, R. W. Neumar, G. Nichol, et al., Circulation 2016, 133, e38.
R. Guo, P. H. Canter, E. Ernst, Postgrad. Med. J. 2007, 83, 633.
S. Tyler, M. Gillespie, V. Eckl, C. M. Reynolds, HerbalGram 2018, 62.
K. Naumann, J. Altern. Complement. Med. 2018, 24, 168.
J. A. Singh, Arthritis Res. Ther. 2017, 19, 204.
F. Blando, C. Gerardi, I. Nicoletti, Biomed. Res. Int. 2004, 2004, 253.
H. E. Khoo, A. Azlan, S. T. Tang, S. M. Lim, Food Nutr. Res. 2017, 61, 1361779.
P. G. Bell, D. C. Gaze, G. W. Davison, T. W. George, M. J. Scotter, G. Howatson, J. Funct. Foods 2014, 11, 82.
E. M. Seymour, S. M. Warber, A. Kirakosyan, K. R. Noon, B. Gillespie, V. E. Uhley, J. Wunder, D. E. Urcuyo, P. B. Kaufman, S. F. Bolling, J. Funct. Foods 2014, 11, 509.
C. Kropat, D. Mueller, U. Boettler, K. Zimmermann, E. H. Heiss, V. M. Dirsch, D. Rogoll, R. Melcher, E. Richling, D. Marko, Mol. Nutr. Food Res. 2013, 57, 545.
N. P. Seeram, R. A. Momin, M. G. Nair, L. D. Bourquin, Phytomedicine 2001, 8, 362.
U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER). Assessing the Effects of Food on Drugs in INDs and NDAs - Clinical Pharmacology Considerations Guidance for Industry (June 2022). Available from: (accessed: November 2022). https://www.fda.gov/media/121313/download
R. M. de Ferrars, C. Czank, S. Saha, P. W. Needs, Q. Zhang, K. S. Raheem, N. P. Botting, P. A. Kroon, C. D. Kay, Anal. Chem. 2014, 86, 10052.
K. J. Livak, T. D. Schmittgen, Methods 2001, 25, 402.
H. Akaike, IEEE Trans. Automat. Contr. 1974, 19, 716.
Y. N. Sun, W. J. Jusko, J. Pharm. Sci. 1998, 87, 732.
N. L. Dayneka, V. Garg, W. J. Jusko, J. Pharmacokinet. Biopharm. 1993, 21, 457.
A. A. Piergies, T. I. Ruo, E. M. Jansyn, S. M. Belknap, A. J. Atkinson, jr., Clin. Pharmacol. Ther. 1987, 42, 107.
A. Cleton, H. J. M. M. de Greef, P. M. Edelbroek, R. A. Voskuyl, M. Danhof, J. Pharmacokinet. Biopharm. 1999, 27, 301.
Q. Lv, D. Xu, X. Zhang, X. Yang, P. Zhao, X. Cui, X. Liu, W. Yang, G. Yang, S. Xing, Front. Physiol. 2020, 11, 524236.
D. Xu, Q. Lv, X. Wang, X. Cui, P. Zhao, X. Yang, X. Liu, W. Yang, G. Yang, G. Wang, P. Wang, Z. Wang, Z. Li, S. Xing, Am. J. Physiol. 2019, 317, G484.
G. L. Amidon, H. Lennernäs, V. P. Shah, J. R. Crison, Pharm. Res. 1995, 12, 413.
D. Dahlgren, C. Roos, A. Lundqvist, B. Abrahamsson, C. Tannergren, P. M. Hellström, E. Sjögren, H. Lennernäs, Mol. Pharm. 2016, 13, 3013.
N. Schlesinger, P. E. Lipsky, K. Jablonski, W. Jarjour, L. Brunetti, N. A. Young, Clin. Exp. Rheumatol. 2022, 40, 1293.
A. Kirakosyan, E. M. Seymour, J. Wolforth, R. McNish, P. B. Kaufman, S. F. Bolling, Food Chem. 2015, 171, 26.
A. Kirakosyan, E. M. Seymour, D. E. U. Llanes, P. B. Kaufman, S. F. Bolling, Food Chem. 2009, 115, 20.
J. Fang, J. Agric. Food Chem. 2014, 62, 3904.
U. Hribar, N. P. Ulrih, Curr. Drug Metab. 2014, 15, 3.
S. Fornasaro, L. Ziberna, M. Gasperotti, F. Tramer, U. Vrhovšek, F. Mattivi, S. Passamonti, Sci. Rep. 2016, 6, 22815.
W. Mullen, C. A. Edwards, M. Serafini, A. Crozier, J. Agric. Food Chem. 2008, 56, 713.
M. E. Eker, K. Aaby, I. Budic-Leto, S. R. Brncic, S. N. El, S. Karakaya, S. Simsek, C. Manach, W. Wiczkowski, S. de Pascual-Teresa, Foods 2019, 9.
H. K. Min, S. M. Kim, S. Y. Baek, J. W. Woo, J.-S. Park, M.-L. Cho, J. Lee, S.-K. Kwok, S. W. Kim, S.-H. Park, PLoS One 2015, 10, e0138201.
G. Howatson, M. P. McHugh, J. A. Hill, J. Brouner, A. P. Jewell, K. A. van Someren, R. E. Shave, S. A. Howatson, Scand. J. Med. Sci. Sports 2010, 20, 843.
Y. H. He, J. Zhou, Y. S. Wang, C. Xiao, Y. Tong, J. C.-O. Tang, A. S.-C. Chan, A.-P. Lu, Scand. J. Rheumatol. 2006, 35, 356.
Y. Zamudio-Cuevas, C. Hernandez-Diaz, C. Pineda, A. M. Reginato, J. F. Cerna-Cortés, L. Ventura-Ríos, A. López-Reyes, Clin. Rheumatol. 2015, 34, 1667.
F. S. di Giovine, S. E. Malawista, E. Thornton, G. W. Duff, J. Clin. Invest. 1991, 87, 1375.
R. Terkeltaub, C. Zachariae, D. Santoro, J. Martin, P. Peveri, K. Matsushima, Arthritis Rheumatol. 1991, 34, 894.
P. A. Guerne, R. Terkeltaub, B. Zuraw, M. Lotz, Arthritis Rheumatol. 1989, 32, 1443.
T. J. Ju, J. M. Dan, Y. J. Cho, S. Y. Park, Korean J. Physiol. Pharmacol. 2011, 15, 363.
Y. Zhu, W. Ling, H. Guo, F. Song, Q. Ye, T. Zou, D. Li, Y. Zhang, G. Li, Y. Xiao, F. Liu, Z. Li, Z. Shi, Y. Yang, Nutr. Metab. Cardiovasc. Dis. 2013, 23, 843.
P. Vitaglione, G. Donnarumma, A. Napolitano, F. Galvano, A. Gallo, L. Scalfi, V. Fogliano, J. Nutr. 2007, 137, 2043.
A. M. Aura, K. A. O'Leary, G. Williamson, M. Ojala, M. Bailey, R. Puupponen-Pimiä, A. M. Nuutila, K.-M. Oksman-Caldentey, K. Poutanen, J. Agric. Food Chem. 2002, 50, 1725.
V. D. Bokkenheuser, C. H. Shackleton, J. Winter, Biochem. J. 1987, 248, 953.
M. Ávila, M. Hidalgo, C. Sánchez-Moreno, C. Pelaez, T. Requena, S. de Pascual-Teresa, Food Res. Int. 2009, 42, 1453.
C. A. Morais, V. V. de Rosso, D. Estadella, L. P. Pisani, J. Nutr. Biochem. 2016, 33, 1.
R. M. de Ferrars, C. Czank, Q. Zhang, N. P. Botting, P. A. Kroon, A. Cassidy, C. D. Kay, Br. J. Pharmacol. 2014, 171, 3268.
Z. Guo, J. Zhang, Z. Wang, K. Y. Ang, S. Huang, Q. Hou, X. Su, J. Qiao, Yi Zheng, L. Wang, E. Koh, H. Danliang, J. Xu, Y. K. Lee, H. Zhang, Sci. Rep. 2016, 6, 20602.
J. A. Rothwell, J. Perez-Jimenez, V. Neveu, A. Medina-Remón, N. M'Hiri, P. García-Lobato, C. Manach, C. Knox, R. Eisner, D. S. Wishart, A. Scalbert, Database 2013, 2013, bat070.
T. Rohrig, V. Kirsch, D. Schipp, J. Galan, E. Richling, J. Agric. Food Chem. 2019, 67, 6792.
T. Nurmi, J. Mursu, M. Heinonen, A. Nurmi, R. Hiltunen, S. Voutilainen, J. Agric. Food Chem. 2009, 57, 2274.
D. Mueller, K. Jung, M. Winter, D. Rogoll, R. Melcher, E. Richling, Food Chem. 2017, 231, 275.
N. Schlesinger, R. Rabinowitz, M. Schlesinger, J. Arthritis 2012, 1, 1.
S. Fruit, Shoreline Fruit FAQs, https://shorelinefruit.com/30/faqs (accessed: November 2022).
R. A. Jacob, G. M. Spinozzi, V. A. Simon, D. S. Kelley, R. L. Prior, B. Hess-Pierce, A. A. Kader, J. Nutr. 2003, 133, 1826.
Y. Zhang, T. Neogi, C. Chen, C. Chaisson, D. J. Hunter, H. K. Choi, Arthritis Rheum. 2012, 64, 4004.