GRHL2 and AP2a coordinate early surface ectoderm lineage commitment during development.
Biological sciences
Cell biology
Developmental biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
17 Mar 2023
17 Mar 2023
Historique:
received:
20
02
2022
revised:
09
05
2022
accepted:
30
01
2023
entrez:
27
2
2023
pubmed:
28
2
2023
medline:
28
2
2023
Statut:
epublish
Résumé
Ectodermal dysplasias including skin abnormalities and cleft lip/palate result from improper surface ectoderm (SE) patterning. However, the connection between SE gene regulatory networks and disease remains poorly understood. Here, we dissect human SE differentiation with multiomics and establish GRHL2 as a key mediator of early SE commitment, which acts by skewing cell fate away from the neural lineage. GRHL2 and master SE regulator AP2a balance early cell fate output, with GRHL2 facilitating AP2a binding to SE loci. In turn, AP2a restricts GRHL2 DNA binding away from
Identifiants
pubmed: 36843855
doi: 10.1016/j.isci.2023.106125
pii: S2589-0042(23)00202-X
pmc: PMC9950457
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106125Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Genesis. 2011 Apr;49(4):307-25
pubmed: 21309073
Nat Commun. 2019 Jun 6;10(1):2487
pubmed: 31171776
Dis Model Mech. 2020 Mar 25;13(3):
pubmed: 32005677
Nature. 1996 May 16;381(6579):238-41
pubmed: 8622766
Nat Genet. 2021 Jun;53(6):830-839
pubmed: 33821002
Nat Biotechnol. 2014 Apr;32(4):381-386
pubmed: 24658644
Dev Cell. 2011 Oct 18;21(4):627-41
pubmed: 21982646
Fetal Pediatr Pathol. 2021 Aug;40(4):337-353
pubmed: 31880477
Hum Mol Genet. 2008 Jan 15;17(2):159-69
pubmed: 17921507
Curr Protoc Cell Biol. 2018 Jun;79(1):e51
pubmed: 29924488
J Oncol. 2009;2009:780874
pubmed: 20066163
Nat Commun. 2017 Mar 13;8:14759
pubmed: 28287101
Development. 2020 Jun 24;147(21):
pubmed: 32467233
Cleft Palate Craniofac J. 2021 Feb;58(2):237-243
pubmed: 32864997
Commun Biol. 2019 Jul 24;2:272
pubmed: 31372511
PLoS Comput Biol. 2013;9(8):e1003118
pubmed: 23950696
Front Genet. 2020 May 13;11:424
pubmed: 32477401
BMC Bioinformatics. 2013 Apr 15;14:128
pubmed: 23586463
Adv Otorhinolaryngol. 2011;70:107-113
pubmed: 21358192
Cell Stem Cell. 2019 Feb 7;24(2):271-284.e8
pubmed: 30686763
EMBO J. 2008 Mar 19;27(6):886-97
pubmed: 18288204
Nature. 1996 May 16;381(6579):235-8
pubmed: 8622765
Nat Methods. 2016 Nov;13(11):919-922
pubmed: 27643841
Nat Biotechnol. 2016 May;34(5):525-7
pubmed: 27043002
Int J Dev Biol. 2010;54(5):837-50
pubmed: 19757382
Nat Genet. 2010 Jan;42(1):24-6
pubmed: 20023658
Nature. 2020 Sep;585(7825):357-362
pubmed: 32939066
PLoS Genet. 2013;9(9):e1003785
pubmed: 24068957
Cell. 2021 Jun 24;184(13):3573-3587.e29
pubmed: 34062119
Dev Biol. 2011 Dec 1;360(1):173-85
pubmed: 21963426
Cell. 2017 May 4;169(4):693-707.e14
pubmed: 28475897
Nat Methods. 2020 Mar;17(3):261-272
pubmed: 32015543
Nat Commun. 2019 Sep 17;10(1):4221
pubmed: 31530818
Mol Med Rep. 2016 Mar;13(3):2857-63
pubmed: 26847018
Nature. 2022 Jun;606(7912):188-196
pubmed: 35585237
Curr Protoc Mol Biol. 2015 Jan 05;109:21.29.1-21.29.9
pubmed: 25559105
Cleft Palate Craniofac J. 2020 Jun;57(6):671-677
pubmed: 31950859
Cell Stem Cell. 2018 Aug 02;23(2):226-238.e4
pubmed: 30017589
Nucleic Acids Res. 2019 Jan 8;47(D1):D1005-D1012
pubmed: 30445434
Am J Hum Genet. 2008 May;82(5):1171-7
pubmed: 18423521
PLoS Comput Biol. 2021 Sep 20;17(9):e1009382
pubmed: 34543288
Birth Defects Res A Clin Mol Teratol. 2012 Nov;94(11):934-42
pubmed: 23008150
Cell. 1995 Sep 22;82(6):969-79
pubmed: 7553857
PLoS Comput Biol. 2020 Apr 14;16(4):e1007819
pubmed: 32287273
Genome Biol. 2008;9(9):R137
pubmed: 18798982
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
EMBO J. 1995 Apr 3;14(7):1508-19
pubmed: 7729426
Hum Genet. 2017 Mar;136(3):275-286
pubmed: 28054174
Development. 2005 Jul;132(13):3127-38
pubmed: 15944192
J Invest Dermatol. 2018 Dec;138(12):2578-2588
pubmed: 29913133
Nat Genet. 2010 Jun;42(6):525-9
pubmed: 20436469
Nat Genet. 2018 Jul;50(7):1011-1020
pubmed: 29867222
J Dent Res. 2017 Oct;96(11):1200-1209
pubmed: 28697314
Development. 2008 Apr;135(7):1377-88
pubmed: 18326838
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W187-91
pubmed: 24799436
Genet Med. 2016 Dec;18(12):1269-1275
pubmed: 27148939
Genome Biol. 2016 May 06;17(1):91
pubmed: 27154141
J Matern Fetal Neonatal Med. 2022 Jul;35(13):2499-2506
pubmed: 32698641
Am J Hum Genet. 2014 Sep 4;95(3):308-14
pubmed: 25152456
Nat Genet. 2018 Dec;50(12):1658-1665
pubmed: 30397335
Bioinformatics. 2018 Feb 15;34(4):672-674
pubmed: 29028898
Congenit Anom (Kyoto). 2014 May;54(2):94-9
pubmed: 24206222
Dev Dyn. 2006 Sep;235(9):2353-75
pubmed: 16680722
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Genome Biol. 2015 Dec 01;16:259
pubmed: 26619908
J Cell Biol. 2006 Jan 30;172(3):409-21
pubmed: 16449191
Bioinformatics. 2015 Apr 15;31(8):1334-6
pubmed: 25431330
Dev Biol. 2007 Apr 1;304(1):338-54
pubmed: 17258188
Bioinformatics. 2010 Mar 15;26(6):841-2
pubmed: 20110278
Dev Dyn. 2016 Mar;245(3):220-32
pubmed: 26332872
Genome Med. 2021 Feb 22;13(1):31
pubmed: 33618777
Nat Protoc. 2017 Dec;12(12):2478-2492
pubmed: 29120462
Dev Biol. 2014 Aug 15;392(2):168-81
pubmed: 24949938
Cell Stem Cell. 2017 Sep 7;21(3):399-410.e7
pubmed: 28886367
Dev Biol. 2010 Nov 1;347(1):109-21
pubmed: 20727875
Elife. 2022 Mar 25;11:
pubmed: 35333176
Dev Biol. 2006 Nov 1;299(1):122-36
pubmed: 16949565
Nat Genet. 2021 Jan;53(1):45-53
pubmed: 33288918
Hum Mol Genet. 2002 Nov 1;11(23):2877-85
pubmed: 12393799
Nat Biotechnol. 2015 May;33(5):495-502
pubmed: 25867923