YKL-40 as a possible marker of neutrophilic asthma.
YKL-40
asthma
asthma biomarker
chitinase-like protein
neutrophilic asthma
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2023
2023
Historique:
received:
04
12
2022
accepted:
23
01
2023
entrez:
27
2
2023
pubmed:
28
2
2023
medline:
28
2
2023
Statut:
epublish
Résumé
Asthma is a heterogeneous chronic disorder of the airways, with inflammation and bronchial hyperresponsiveness as its major underlying phenomena. Asthmatics vary in terms of inflammation pattern, concomitant pathologies, and factors aggravating the course of the disease. As a result, there is a need for sensitive and specific biomarkers that could facilitate diagnosing asthma as well as phenotyping in everyday practice. Chitinases and chitinase-like proteins (CLPs) seem promising in this field. Chitinases are evolutionarily conserved hydrolases that degrade chitin. In contrast, CLPs bind chitin but do not have degrading activity. Mammalian chitinases and CLPs are produced by neutrophils, monocytes, and macrophages in response to parasitic or fungal infections. Recently, several questions have been raised about their role in chronic airway inflammation. Several studies demonstrated that overexpression of CLP YKL-40 was associated with asthma. Moreover, it correlated with exacerbation rate, therapy resistance, poor control of symptoms, and, inversely, with FEV
Identifiants
pubmed: 36844232
doi: 10.3389/fmed.2023.1115938
pmc: PMC9945318
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1115938Informations de copyright
Copyright © 2023 Specjalski, Romantowski and Niedoszytko.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Curr Opin Allergy Clin Immunol. 2009 Oct;9(5):401-8
pubmed: 19644363
Am J Respir Crit Care Med. 2009 Mar 15;179(6):449-56
pubmed: 19106306
Lancet. 2008 Sep 20;372(9643):1107-19
pubmed: 18805339
N Engl J Med. 2008 Mar 6;358(10):1073-5; author reply 1075
pubmed: 18322291
Cancer. 2002 Jul 15;95(2):267-74
pubmed: 12124825
Clin Chim Acta. 2011 Apr 11;412(9-10):709-12
pubmed: 21272568
J Allergy Clin Immunol. 2011 Feb;127(2):355-60
pubmed: 21281866
J Allergy Clin Immunol. 2013 Aug;132(2):328-35.e5
pubmed: 23628340
Respir Res. 2019 May 22;20(1):95
pubmed: 31113430
Medicine (Baltimore). 2019 Nov;98(47):e17950
pubmed: 31764795
Exp Cell Res. 2003 Jul 1;287(1):79-87
pubmed: 12799184
Am J Respir Crit Care Med. 2012 Apr 1;185(7):715-22
pubmed: 22281830
Cell Biol Int. 2021 Dec;45(12):2557-2566
pubmed: 34498339
Cancer Cell Int. 2019 Oct 10;19:259
pubmed: 31624472
J Clin Med. 2022 Sep 23;11(19):
pubmed: 36233472
J Allergy Clin Immunol. 2005 Sep;116(3):497-500
pubmed: 16159614
J Leukoc Biol. 2002 Apr;71(4):597-602
pubmed: 11927645
Allergy Asthma Proc. 2021 Nov 1;42(6):e167-e173
pubmed: 34871165
Clin Chem Lab Med. 2005;43(5):499-502
pubmed: 15899671
Am J Respir Crit Care Med. 1996 Nov;154(5):1497-504
pubmed: 8912771
J Biol Chem. 2000 Jan 14;275(2):1279-86
pubmed: 10625674
FASEB J. 1998 Jan;12(1):57-65
pubmed: 9438411
Cardiol Res Pract. 2022 Aug 23;2022:4905954
pubmed: 36051575
Scand J Rheumatol. 2006 Nov-Dec;35(6):489-91
pubmed: 17343261
Nat Med. 2012 May 04;18(5):716-25
pubmed: 22561835
N Engl J Med. 2007 Nov 15;357(20):2016-27
pubmed: 18003958
Genetics. 2007 Oct;177(2):959-70
pubmed: 17720922
Int Immunopharmacol. 2020 Nov;88:106878
pubmed: 32791244
Cell Cycle. 2016 Oct 17;15(20):2819-26
pubmed: 27579513
Nature. 2007 May 3;447(7140):92-6
pubmed: 17450126
Science. 2004 Jun 11;304(5677):1678-82
pubmed: 15192232
Am J Med. 1947 Nov;3(5):601-6
pubmed: 20269240
Br J Rheumatol. 1996 Jun;35(6):553-9
pubmed: 8670576
Eur Respir J. 2010 Apr;35(4):757-60
pubmed: 20356987
Respir Med. 2006 Apr;100(4):648-57
pubmed: 16159709
J Allergy Clin Immunol Pract. 2019 Sep - Oct;7(7):2466-2468.e3
pubmed: 30954645
Science. 1993 Jan 1;259(5091):87-91
pubmed: 7678183
J Biol Chem. 2011 Apr 29;286(17):15332-43
pubmed: 21385870
Pneumologie. 2014 Dec;68(12):784-7
pubmed: 25489866
J Med Chem. 2019 Aug 8;62(15):7126-7145
pubmed: 31291098
Int J Chron Obstruct Pulmon Dis. 2018 Jan 30;13:409-418
pubmed: 29430175
Sleep Breath. 2022 Sep;26(3):1011-1022
pubmed: 34657273
Pediatr Allergy Immunol. 2021 Jan;32(1):77-85
pubmed: 32786104
J Immunol. 2000 Feb 1;164(3):1314-21
pubmed: 10640745
Pediatr Allergy Immunol. 2010 Nov;21(7):1015-20
pubmed: 20977500
Respir Res. 2019 Dec 12;20(1):282
pubmed: 31831011
J Exp Med. 2009 May 11;206(5):1149-66
pubmed: 19414556
PLoS One. 2011;6(9):e24177
pubmed: 21915293
Respiration. 2012;83(6):507-19
pubmed: 21968467
Allergol Int. 2021 Jan;70(1):136-139
pubmed: 32571644
Eur Respir J. 2017 Oct 12;50(4):
pubmed: 29025889
Respir Res. 2018 Mar 27;19(1):47
pubmed: 29580282
Thorax. 2007 Dec;62(12):1043-9
pubmed: 17356056
Arch Gynecol Obstet. 2022 Feb;305(2):467-473
pubmed: 34417838
Eur Heart J. 2009 May;30(9):1066-72
pubmed: 19270316
Lung. 2015 Apr;193(2):189-94
pubmed: 25663327
BMC Pulm Med. 2015 Jan 12;15:1
pubmed: 25578181
Am J Respir Crit Care Med. 2005 Dec 15;172(12):1505-9
pubmed: 16179638