Neurobiology of Disorganized Attachment: A Review of Primary Studies on Human Beings.
Neurobiology
neurophysiology
psychology
review
Journal
Neuroscience insights
ISSN: 2633-1055
Titre abrégé: Neurosci Insights
Pays: United States
ID NLM: 101760670
Informations de publication
Date de publication:
2023
2023
Historique:
received:
25
05
2022
accepted:
28
11
2022
entrez:
27
2
2023
pubmed:
28
2
2023
medline:
28
2
2023
Statut:
epublish
Résumé
This article describes and analyzes various aspects related to the neurobiology of disorganized attachment (DA), which is associated with personality, eating, affective, dissociative, and addictive disorders. We included primary studies in humans, published in PubMed from 2000 to 2022. Eight genetic and one epigenetic study were considered. Three molecular studies describe possible roles of oxytocin and cortisol, seven neurophysiological studies investigated functional correlates, and five morphological studies describe anatomical changes. Findings in candidate genes involved in dopaminergic, serotonergic, and oxytonergic systems have not been able to be replicated in large-scale human studies. Alterations in the functioning of cortisol and oxytocin are preliminary. Neurophysiological studies show changes in subcortical structures (mainly in the hippocampus) and occipital, temporal, parietal, and insular cortices. Since there is a lack of robust evidence on the neurobiology of DA in humans, the possible inferences of these studies are preliminary, which restricts their translation to clinical parameters.
Identifiants
pubmed: 36844427
doi: 10.1177/26331055221145681
pii: 10.1177_26331055221145681
pmc: PMC9947683
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
26331055221145681Informations de copyright
© The Author(s) 2023.
Déclaration de conflit d'intérêts
The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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