Signature of miRNAs derived from the circulating exosomes of patients with amyotrophic lateral sclerosis.
amyotrophic lateral sclerosis
diagnostic model
exosomes
gene mutation
microRNAs
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2023
2023
Historique:
received:
23
11
2022
accepted:
09
01
2023
entrez:
27
2
2023
pubmed:
28
2
2023
medline:
28
2
2023
Statut:
epublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disorder (NDS) with unclear pathophysiology and few therapeutic options. Mutations in We compared circulating exosome-derived miRNAs of patients with ALS and HCs using the following two cohorts: a discovery cohort (three patients with A total of 64 differentially expressed miRNAs in patients with Our study identified aberrant miRNAs from exosomes of SALS and ALS patients with
Sections du résumé
Background
UNASSIGNED
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disorder (NDS) with unclear pathophysiology and few therapeutic options. Mutations in
Methods
UNASSIGNED
We compared circulating exosome-derived miRNAs of patients with ALS and HCs using the following two cohorts: a discovery cohort (three patients with
Results
UNASSIGNED
A total of 64 differentially expressed miRNAs in patients with
Conclusion
UNASSIGNED
Our study identified aberrant miRNAs from exosomes of SALS and ALS patients with
Identifiants
pubmed: 36845651
doi: 10.3389/fnagi.2023.1106497
pmc: PMC9951117
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1106497Informations de copyright
Copyright © 2023 Cheng, Gu, Yang, Wei, Cao, Zhang, Shang and Chen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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