Cortisol and ACTH Measurements at Extubation From Pituitary Surgery Predicts Hypothalamic-Pituitary-Adrenal Axis Function.

Cushing's disease hypercortisolism pituitary adenoma remission transsphenoidal surgery

Journal

Journal of the Endocrine Society
ISSN: 2472-1972
Titre abrégé: J Endocr Soc
Pays: United States
ID NLM: 101697997

Informations de publication

Date de publication:
09 Feb 2023
Historique:
received: 08 12 2022
entrez: 27 2 2023
pubmed: 28 2 2023
medline: 28 2 2023
Statut: epublish

Résumé

Early prediction of hypothalamic-pituitary-adrenal (HPA) axis function following transsphenoidal surgery (TSS) can improve patient safety and reduce costs. Systematic measurement of ACTH and cortisol at extubation following anesthesia to predict remission from Cushing's disease (CD) and HPA axis preservation following non-CD surgery. Retrospective analysis of clinical data between August 2015 and May 2022. Referral center. Consecutive patients (n = 129) undergoing TSS who had perioperative ACTH and cortisol measurements. ACTH and cortisol measurement at extubation. Further serial 6-hourly measurements in CD patients. Prediction of future HPA axis status based on ACTH/cortisol at extubation. ACTH and cortisol increased sharply in all patients at extubation. CD patients (n = 101) had lower ACTH values than non-CD patients (110.1 vs 293.1 pg/mL; We found that at extubation following TSS, ACTH can predict the need for eventual steroid replacement in non-Cushing's patients. In patients with CD, we found a robust prediction of nonremission with NEPV cortisol at extubation and later.

Identifiants

pubmed: 36846212
doi: 10.1210/jendso/bvad025
pii: bvad025
pmc: PMC9954986
doi:

Types de publication

Journal Article

Langues

eng

Pagination

bvad025

Informations de copyright

Published by Oxford University Press on behalf of the Endocrine Society 2023.

Références

J Neurosurg. 2012 Apr;116(4):721-7
pubmed: 22283193
Eur J Endocrinol. 2018 Mar;178(3):255-263
pubmed: 29330227
Curr Probl Surg. 1994 Aug;31(8):658-720
pubmed: 8045159
Pituitary. 2010 Sep;13(3):249-55
pubmed: 20339931
Mayo Clin Proc. 1978 Jan;53(1):24-8
pubmed: 625141
Physiol Rev. 1999 Jan;79(1):1-71
pubmed: 9922367
Neurosurgery. 2019 Mar 1;84(3):616-623
pubmed: 30767017
J Neurosurg. 1989 Oct;71(4):520-7
pubmed: 2552045
Clin Endocrinol (Oxf). 2001 Jul;55(1):61-8
pubmed: 11453953
J Clin Endocrinol Metab. 2005 Sep;90(9):5478-82
pubmed: 15956075
Lancet Diabetes Endocrinol. 2021 Dec;9(12):847-875
pubmed: 34687601
Acta Neurochir (Wien). 2007;149(5):471-7; discussion 477-9
pubmed: 17406780
J Clin Endocrinol Metab. 1993 Nov;77(5):1308-12
pubmed: 8077325
J Clin Endocrinol Metab. 2001 Nov;86(11):5554-63
pubmed: 11701735
N Engl J Med. 1991 Sep 26;325(13):897-905
pubmed: 1652686
Science. 1985 Nov 29;230(4729):1035-7
pubmed: 2997929
J Clin Endocrinol Metab. 1987 Nov;65(5):906-13
pubmed: 3499448
J Clin Endocrinol Metab. 2014 Nov;99(11):3933-51
pubmed: 25356808
Br J Surg. 1992 Aug;79(8):757-60
pubmed: 1393463
J Clin Endocrinol Metab. 2011 Jul;96(7):2057-64
pubmed: 21508126
Eur J Endocrinol. 2020 May;182(5):489-498
pubmed: 32187576
Neurosurgery. 2012 Jan;70(1):70-80; discussion 80-1
pubmed: 21772221
Ann Endocrinol (Paris). 2015 Jul;76(3):191-200
pubmed: 26054868
J Clin Endocrinol Metab. 2008 May;93(5):1526-40
pubmed: 18334580
J Clin Endocrinol Metab. 2017 Jul 1;102(7):2179-2187
pubmed: 28323961
J Neurosurg. 2016 Mar;124(3):589-95
pubmed: 26252454
J Clin Endocrinol Metab. 1997 Jun;82(6):1776-9
pubmed: 9177381
J Clin Endocrinol Metab. 1994 Feb;78(2):418-22
pubmed: 8106630
J Clin Endocrinol Metab. 2015 Aug;100(8):2807-31
pubmed: 26222757
Clin Endocrinol (Oxf). 2001 May;54(5):609-16
pubmed: 11380491
J Clin Endocrinol Metab. 2012 Apr;97(4):1285-93
pubmed: 22337905
J Clin Endocrinol Metab. 2009 Aug;94(8):2757-65
pubmed: 19470618
Biometrika. 1947;34(1-2):28-35
pubmed: 20287819
J Neurosurg. 2017 Feb;126(2):404-417
pubmed: 27104844
J Clin Neurosci. 2021 Jul;89:113-121
pubmed: 34119253
Neurosurg Focus. 2007;23(3):E6
pubmed: 17961022
J Clin Endocrinol Metab. 2004 Mar;89(3):1131-9
pubmed: 15001598
Eur J Endocrinol. 2018 May;178(5):R201-R214
pubmed: 29472379
J Clin Endocrinol Metab. 2002 Apr;87(4):1646-53
pubmed: 11932296
J Clin Endocrinol Metab. 1987 May;64(5):986-94
pubmed: 3031124
Ann Endocrinol (Paris). 2015 Jul;76(3):239-47
pubmed: 26072284
J Neurosurg. 1994 Jan;80(1):37-45
pubmed: 8271020
Pituitary. 2013 Jun;16(2):139-45
pubmed: 22466318
Clin Endocrinol (Oxf). 2006 Aug;65(2):265-73
pubmed: 16886971
J Clin Endocrinol Metab. 1998 Apr;83(4):1163-7
pubmed: 9543134
J Clin Endocrinol Metab. 2009 Aug;94(8):2930-7
pubmed: 19509103
J Clin Endocrinol Metab. 1999 Feb;84(2):440-8
pubmed: 10022398
Endocr Pract. 2019 Apr;25(4):353-360
pubmed: 30720340
Clin Endocrinol (Oxf). 2012 Feb;76(2):253-63
pubmed: 21781143

Auteurs

David T Asuzu (DT)

Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, MD, USA.
Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, MD, USA.
Department of Neurosurgery, University of Virginia, Charlottesville, VA, USA.

Shyama Bhatt (S)

Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, MD, USA.

Diana Nwokoye (D)

Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, MD, USA.

Christina Hayes (C)

Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, MD, USA.

Michaela Cortes (M)

Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, MD, USA.

Raven McGlotten (R)

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

Meg Keil (M)

Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Christina Tatsi (C)

Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Lynnette Nieman (L)

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

Prashant Chittiboina (P)

Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, MD, USA.
Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, MD, USA.

Classifications MeSH