Effects of GABA

Extracellular single-unit recording GABAB receptors Lateral habenula Morphine

Journal

Research in pharmaceutical sciences

ISSN: 1735-5362

Titre abrégé: Res Pharm Sci

Pays: Iran

ID NLM: 101516968

Informations de publication

Date de publication:
Feb 2023

Historique:

received: 31 05 2022

revised: 22 08 2022

accepted: 15 11 2022

entrez: 27 2 2023

pubmed: 28 2 2023

medline: 28 2 2023

Statut: epublish

Résumé

The lateral habenula (LHb), a key area in the regulation of the reward system, exerts a major influence on midbrain neurons. It has been shown that the gamma-aminobutyric acid (GABA)- ergic system plays the main role in morphine dependency. The role of GABA type B receptors (GABA The baseline firing rate was recorded for 15 min, then morphine (5 mg/kg; s.c) and phaclofen (0, 0.5, 1, and 2 μg/rat), a GABA The results revealed that morphine decreased neuronal activity, and GABA This result indicated that GABA

Sections du résumé

Background and purpose UNASSIGNED

Experimental approach UNASSIGNED

The baseline firing rate was recorded for 15 min, then morphine (5 mg/kg; s.c) and phaclofen (0, 0.5, 1, and 2 μg/rat), a GABA

Findings/Results UNASSIGNED

The results revealed that morphine decreased neuronal activity, and GABA

Conclusion and implications UNASSIGNED

This result indicated that GABA

Identifiants

DOI: 10.4103/1735-5362.363592 PMID: 36846735 PMC: PMC9951782

pubmed: 36846735

doi: 10.4103/1735-5362.363592

pii: RPS-18-16

pmc: PMC9951782

doi:

Types de publication

Journal Article

Langues

eng

Pagination

16-23

Informations de copyright

Déclaration de conflit d'intérêts

The authors declared no conflict of interest in this study.

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