New Concepts in Barrier Dysfunction in CRSwNP and Emerging Roles of Tezepelumab and Dupilumab.
AERD
TSLP
allergic rhinitis
asthma
atopic dermatitis
barrier dysfunction
chronic rhinosinusitis
dupilumab
nasal polyps
tezepelumab
Journal
American journal of rhinology & allergy
ISSN: 1945-8932
Titre abrégé: Am J Rhinol Allergy
Pays: United States
ID NLM: 101490775
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
entrez:
27
2
2023
pubmed:
28
2
2023
medline:
3
3
2023
Statut:
ppublish
Résumé
Epithelial barrier disturbances in CRSwNP patients play an important role in both the innate and adaptive immune responses, contributing to chronic inflammation, olfactory dysfunction, and impairments in quality of life. To evaluate the role of the sinonasal epithelium in disease and health, review the pathophysiology of epithelial barrier dysfunction in CRSwNP, and the immunologic targets for treatment. Literature review. Blockade of cytokines such as thymic stromal lymphopoietin (TSLP), IL-4, and IL-13 have shown promise in barrier restoration and IL-13, specifically may be central to olfactory dysfunction. The sinonasal epithelium plays a crucial role in the health and function of the mucosa and immune response. Increased understanding of the local immunologic dysfunction has led to several therapeutics that can potentially restore epithelial barrier function and olfaction. Real world and comparative effectiveness studies are needed.
Sections du résumé
BACKGROUND
BACKGROUND
Epithelial barrier disturbances in CRSwNP patients play an important role in both the innate and adaptive immune responses, contributing to chronic inflammation, olfactory dysfunction, and impairments in quality of life.
OBJECTIVE
OBJECTIVE
To evaluate the role of the sinonasal epithelium in disease and health, review the pathophysiology of epithelial barrier dysfunction in CRSwNP, and the immunologic targets for treatment.
METHODS
METHODS
Literature review.
RESULTS
RESULTS
Blockade of cytokines such as thymic stromal lymphopoietin (TSLP), IL-4, and IL-13 have shown promise in barrier restoration and IL-13, specifically may be central to olfactory dysfunction.
CONCLUSION
CONCLUSIONS
The sinonasal epithelium plays a crucial role in the health and function of the mucosa and immune response. Increased understanding of the local immunologic dysfunction has led to several therapeutics that can potentially restore epithelial barrier function and olfaction. Real world and comparative effectiveness studies are needed.
Identifiants
pubmed: 36848281
doi: 10.1177/19458924231154061
doi:
Substances chimiques
tezepelumab
RJ1IW3B4QX
dupilumab
420K487FSG
Interleukin-13
0
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM