Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor.

Animals Mice Guanine Nucleotide Exchange Factors / metabolism rac1 GTP-Binding Protein / metabolism Cytokinesis Mutagenesis cdc42 GTP-Binding Protein / metabolism
Cdc42 DOCK GEF GTPase Rac Rho

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
23 04 2023
Historique:
received: 07 02 2023
accepted: 19 02 2023
pubmed: 28 2 2023
medline: 22 3 2023
entrez: 27 2 2023
Statut: ppublish

Résumé

Dedicator of cytokinesis 10 (DOCK10), an evolutionarily conserved guanine nucleotide exchange factor (GEF) for Rho GTPases, has the unique specificity within the DOCK-D subfamily to activate both Cdc42 and Rac, but the structural bases for these activities remained unknown. Here we present the crystal structures of the catalytic DHR2 domain of mouse DOCK10, complexed with either Cdc42 or Rac1. The structures revealed that DOCK10

Identifiants

DOI: 10.1016/j.bbrc.2023.02.054 PMID: 36848820
pubmed: 36848820
pii: S0006-291X(23)00227-9
doi: 10.1016/j.bbrc.2023.02.054
pii:
doi:

Substances chimiques

Guanine Nucleotide Exchange Factors 0
rac1 GTP-Binding Protein EC 3.6.5.2
cdc42 GTP-Binding Protein EC 3.6.5.2
DOCK10 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12-20

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Mutsuko Kukimoto-Niino (M)

Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan. Electronic address: kukimoto@riken.jp.

Kentaro Ihara (K)

Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.

Chiemi Mishima-Tsumagari (C)

Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.

Mio Inoue (M)

Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.

Yoshinori Fukui (Y)

Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Shigeyuki Yokoyama (S)

RIKEN Cluster for Science, Technology and Innovation Hub, Yokohama, Japan.

Mikako Shirouzu (M)

Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.

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Classifications MeSH

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questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Facteurs d'échange de nucléotides guanyliques › Structural basis for the dual GTPase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rho › Protéines G rac › Protéine G rac1 › Structural basis for the dual GTPase...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Cytocinèse › Structural basis for the dual GTPase...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Structural basis for the dual GTPase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rho › Protéine G cdc42 › Structural basis for the dual GTPase...