Genetics in reproductive endocrinology and infertility.
aneuploidy
genetics
monogenic disorder
preimplantation genetic testing
Journal
Fertility and sterility
ISSN: 1556-5653
Titre abrégé: Fertil Steril
Pays: United States
ID NLM: 0372772
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
10
01
2023
revised:
19
02
2023
accepted:
20
02
2023
medline:
28
8
2023
pubmed:
28
2
2023
entrez:
27
2
2023
Statut:
ppublish
Résumé
Tremendous advances in genetics have transformed the field of reproductive endocrinology and infertility over the last few decades. One of the most prominent advances is preimplantation genetic testing (PGT), which allows for the screening of embryos obtained during in vitro fertilization before transfer. Moreover, PGT can be performed for aneuploidy screening, detection of monogenic disorders, or exclusion of structural rearrangements. Refinement of biopsy techniques, such as obtaining samples at the blastocyst rather than the cleavage stage, has helped optimize results from PGT, and technological advances, including next-generation sequencing, have made PGT more efficient and accurate. The continued evolution of the approach to PGT has the potential to further enhance the accuracy of results, expand the application to other conditions, and increase access by reducing cost and improving efficiency.
Identifiants
pubmed: 36849035
pii: S0015-0282(23)00162-0
doi: 10.1016/j.fertnstert.2023.02.029
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
521-527Informations de copyright
Copyright © 2023 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.