Evaluation of the parameters affecting the loading of anticancer drug Paclitaxel on coated gold nanoparticles for breast cancer treatment.
cancer
nanomedicine
nanoparticles
Journal
IET nanobiotechnology
ISSN: 1751-875X
Titre abrégé: IET Nanobiotechnol
Pays: United States
ID NLM: 101303205
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
revised:
28
01
2023
received:
03
10
2022
accepted:
07
02
2023
medline:
19
5
2023
pubmed:
1
3
2023
entrez:
28
2
2023
Statut:
ppublish
Résumé
The purpose of this study is the design and synthesis of gold nanoparticles (GNPs) conjugated with paclitaxel and to investigate the parameters affecting the stability of synthesised nanoparticles with drug delivery capability. Here, synthesised GNPs were coated with polyethylene glycol. Then these particles were conjugated with paclitaxel under different conditions and the physical and structural characteristics, as well as the factors affecting the loading of paclitaxel on nanoparticles, were evaluated by ultraviolet spectrophotometer, fourier transform infrared spectroscopy, transmission electron microscopy, dynamic light scattering and zeta potential apparatus. It was found that pegylated GNPs have a limited loading capacity at the time of 24 h of incubation and the Paclitaxel loading was observed to be pH dependent. The use of these particles in the treatment of breast cancer (MCF7) was also investigated using the MTT test. It was determined that the survival percentage of MCF7 cells in the presence of paclitaxel-bound nanoparticles decreases to about 55% at the maximum measured concentration (690 μM).
Identifiants
pubmed: 36849875
doi: 10.1049/nbt2.12121
pmc: PMC10190534
doi:
Substances chimiques
Paclitaxel
P88XT4IS4D
Gold
7440-57-5
Antineoplastic Agents
0
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
234-245Informations de copyright
© 2023 The Authors. IET Nanobiotechnology published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology.
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