The D405N Mutation in the Spike Protein of SARS-CoV-2 Omicron BA.5 Inhibits Spike/Integrins Interaction and Viral Infection of Human Lung Microvascular Endothelial Cells.
Omicron variant
SARS-CoV-2
endothelial cell dysfunction
integrins
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
24 01 2023
24 01 2023
Historique:
received:
20
12
2022
revised:
19
01
2023
accepted:
22
01
2023
entrez:
28
2
2023
pubmed:
1
3
2023
medline:
3
3
2023
Statut:
epublish
Résumé
Severe COVID-19 is characterized by angiogenic features, such as intussusceptive angiogenesis, endothelialitis, and activation of procoagulant pathways. This pathological state can be ascribed to a direct SARS-CoV-2 infection of human lung ECs. Recently, we showed the capability of SARS-CoV-2 to infect ACE2-negative primary human lung microvascular endothelial cells (HL-mECs). This occurred through the interaction of an Arg-Gly-Asp (RGD) motif, endowed on the Spike protein at position 403-405, with α
Identifiants
pubmed: 36851546
pii: v15020332
doi: 10.3390/v15020332
pmc: PMC9962894
pii:
doi:
Substances chimiques
spike protein, SARS-CoV-2
0
Spike Glycoprotein, Coronavirus
0
Integrins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Angiogenesis. 2022 Nov 12;:
pubmed: 36371548
Int J Mol Sci. 2022 Sep 09;23(18):
pubmed: 36142365
J Med Virol. 2021 Mar;93(3):1780-1785
pubmed: 32926453
Science. 2020 May 1;368(6490):489-493
pubmed: 32179701
Nat Rev Immunol. 2020 Jul;20(7):389-391
pubmed: 32439870
N Engl J Med. 2022 Apr 14;386(15):1397-1408
pubmed: 35172054
Viruses. 2020 Dec 26;13(1):
pubmed: 33375371
Open Biol. 2020 Aug;10(8):200208
pubmed: 32847471
Drug Discov Today. 2020 Dec;25(12):2317-2325
pubmed: 33035665
Crit Care. 2020 Jun 16;24(1):353
pubmed: 32546188
mBio. 2020 Dec 11;11(6):
pubmed: 33310781
Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L277-L288
pubmed: 32551862
Curr Pharm Des. 2009;15(25):2946-57
pubmed: 19754371
Bioinformatics. 2021 May 5;37(5):714-716
pubmed: 32814953
PLoS One. 2021 Jun 2;16(6):e0252827
pubmed: 34077448
PLoS One. 2021 Jun 23;16(6):e0253347
pubmed: 34161337
BMJ. 2020 Sep 4;370:m3379
pubmed: 32887691
Emerg Infect Dis. 2020 Jul;26(7):
pubmed: 32364890
Infect Dis Now. 2021 May;51(3):296-299
pubmed: 33495765
J Biol Chem. 2001 Jun 22;276(25):22420-5
pubmed: 11304529
Sci Rep. 2022 Jul 25;12(1):11855
pubmed: 35879338
Virus Evol. 2018 Jan 08;4(1):vex042
pubmed: 29340210
Lancet. 2020 May 2;395(10234):1417-1418
pubmed: 32325026
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Lancet Respir Med. 2020 Dec;8(12):e95
pubmed: 33035468
JAMA Netw Open. 2022 Oct 3;5(10):e2238354
pubmed: 36282501
Annu Rev Virol. 2014 Nov;1(1):285-306
pubmed: 26958723
N Engl J Med. 2020 Jul 9;383(2):120-128
pubmed: 32437596
Cell. 2020 Nov 25;183(5):1354-1366.e13
pubmed: 33065030
Nat Immunol. 2021 Jan;22(1):19-24
pubmed: 33208929
Kidney Int. 2020 Aug;98(2):505-506
pubmed: 32446936
Lancet. 2020 May 16;395(10236):1569-1578
pubmed: 32423584
Clin Transl Immunology. 2021 Oct 24;10(10):e1350
pubmed: 34721846
J Biol Chem. 2022 Mar;298(3):101695
pubmed: 35143839
Nature. 2022 Aug;608(7923):593-602
pubmed: 35714668
Elife. 2021 Mar 23;10:
pubmed: 33752798
Eur Heart J. 2020 Sep 1;41(32):3038-3044
pubmed: 32882706
Annu Rev Virol. 2020 Sep 29;7(1):143-165
pubmed: 32396772
Front Cell Infect Microbiol. 2021 Jul 06;11:701278
pubmed: 34307198
Vascul Pharmacol. 2021 Apr;137:106829
pubmed: 33422689
J Thromb Haemost. 2020 Sep;18(9):2103-2109
pubmed: 32558075
Front Immunol. 2020 Oct 08;11:583373
pubmed: 33149733
Int J Mol Sci. 2022 Feb 25;23(5):
pubmed: 35269703
Bioinformatics. 2018 Dec 1;34(23):4121-4123
pubmed: 29790939
Euro Surveill. 2017 Mar 30;22(13):
pubmed: 28382917
N Engl J Med. 2022 Feb 17;386(7):e14
pubmed: 35108465
Lancet. 2020 May 30;395(10238):e99
pubmed: 32442529
J Infect Public Health. 2022 May 14;15(6):689-702
pubmed: 35643053
Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):
pubmed: 35078919
J Transl Med. 2020 Sep 23;18(1):362
pubmed: 32967693
EBioMedicine. 2022 Dec;86:104328
pubmed: 36335670
Nat Chem Biol. 2022 Jan;18(1):81-90
pubmed: 34754101
Mol Biol Evol. 2020 May 1;37(5):1530-1534
pubmed: 32011700
Cold Spring Harb Perspect Med. 2022 Oct 3;12(10):
pubmed: 35534210
Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):846-56
pubmed: 24482377
Signal Transduct Target Ther. 2021 Jul 7;6(1):255
pubmed: 34234112
Front Pharmacol. 2020 Jun 12;11:912
pubmed: 32595513
Cell Stem Cell. 2020 Jul 2;27(1):125-136.e7
pubmed: 32579880
Circulation. 2021 Feb 23;143(8):865-868
pubmed: 33405941
Nature. 2022 Aug;608(7923):603-608
pubmed: 35790190
Sci Rep. 2022 Oct 7;12(1):16878
pubmed: 36207386
Nat Rev Dis Primers. 2019 Mar 14;5(1):18
pubmed: 30872586
Microorganisms. 2021 Jul 03;9(7):
pubmed: 34361874
Nat Med. 2020 Jul;26(7):1017-1032
pubmed: 32651579
Int J Lab Hematol. 2020 Oct;42(5):e211-e212
pubmed: 32441844
EBioMedicine. 2022 Nov;85:104296
pubmed: 36206625
Glob Chall. 2017 Jan 10;1(1):33-46
pubmed: 31565258
Immunol Rev. 2016 Nov;274(1):307-329
pubmed: 27782324
Nature. 2022 Mar;603(7902):715-720
pubmed: 35104836
JAMA Netw Open. 2021 Dec 1;4(12):e2140568
pubmed: 34935924
Front Immunol. 2022 Jan 05;12:780804
pubmed: 35069552
Clin Med (Lond). 2020 Sep;20(5):e178-e182
pubmed: 32694169
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Bioinformatics. 2018 Sep 15;34(18):3094-3100
pubmed: 29750242
N Engl J Med. 2022 Jan 13;386(2):116-127
pubmed: 34942067
Front Immunol. 2022 Oct 28;13:933960
pubmed: 36389697
Curr Hypertens Rep. 2020 Aug 27;22(9):63
pubmed: 32852642
J Pathol. 2020 Jul;251(3):228-248
pubmed: 32418199
Cell. 2020 May 14;181(4):894-904.e9
pubmed: 32275855
Viruses. 2022 Mar 29;14(4):
pubmed: 35458435