Prediction of Coreceptor Tropism in HIV-1 Subtype C in Botswana.
CCR5
CXCR4
HIV-1C tropism
R5-tropic viruses
X4-tropic viruses
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
31 01 2023
31 01 2023
Historique:
received:
31
12
2022
revised:
25
01
2023
accepted:
26
01
2023
entrez:
28
2
2023
pubmed:
1
3
2023
medline:
3
3
2023
Statut:
epublish
Résumé
It remains unknown whether the C-C motif chemokine receptor type 5 (CCR5) coreceptor is still the predominant coreceptor used by Human Immunodeficiency Virus-1 (HIV-1) in Botswana, where the HIV-1 subtype C predominates. We sought to determine HIV-1C tropism in Botswana using genotypic tools, taking into account the effect of antiretroviral treatment (ART) and virologic suppression. HIV-1 gp120 V3 loop sequences from 5602 participants were analyzed for viral tropism using three coreceptor use predicting algorithms/tools: Geno2pheno, HIV-1C Web Position-Specific Score Matrices (WebPSSM) and the 11/25 charge rule. We then compared the demographic and clinical characteristics of people living with HIV (PLWH) harboring R5- versus X4-tropic viruses using χ
Identifiants
pubmed: 36851617
pii: v15020403
doi: 10.3390/v15020403
pmc: PMC9963705
pii:
doi:
Substances chimiques
Anti-Retroviral Agents
0
Banques de données
ClinicalTrials.gov
['NCT01965470']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : FIC NIH HHS
ID : K43 TW012350
Pays : United States
Organisme : NHGRI NIH HHS
ID : U41 HG006941
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW009610
Pays : United States
Organisme : PEPFAR
ID : U01 GH000447
Pays : United States
Organisme : Medical Research Council
ID : MR/R015600/1
Pays : United Kingdom
Références
N Engl J Med. 2019 Jul 18;381(3):230-242
pubmed: 31314967
J Acquir Immune Defic Syndr. 2014 Apr 1;65(4):397-404
pubmed: 24189148
J Clin Microbiol. 2011 Sep;49(9):3380-2
pubmed: 21734029
Virology. 2006 Apr 10;347(2):247-60
pubmed: 16406460
AIDS. 2019 May 1;33(6):1073-1082
pubmed: 30946161
Nat Biotechnol. 2007 Dec;25(12):1407-10
pubmed: 18066037
AIDS Res Hum Retroviruses. 2002 Mar 20;18(5):343-52
pubmed: 11897036
Nature. 1996 Jun 20;381(6584):661-6
pubmed: 8649511
J Virol. 2003 Dec;77(24):13376-88
pubmed: 14645592
Nature. 1996 Jun 20;381(6584):667-73
pubmed: 8649512
AIDS Res Hum Retroviruses. 2012 Apr;28(4):324-32
pubmed: 21819257
AIDS Res Hum Retroviruses. 2014 May;30(5):436-45
pubmed: 24205895
AIDS Res Hum Retroviruses. 2017 May 25;33(11):1083-1098
pubmed: 28540766
Virology. 1998 Feb 15;241(2):181-8
pubmed: 9499793
Lancet Infect Dis. 2011 May;11(5):394-407
pubmed: 21429803
J Virol. 1999 Aug;73(8):6271-81
pubmed: 10400718
J Infect Dis. 2006 Oct 1;194(7):926-30
pubmed: 16960780
Lancet HIV. 2016 May;3(5):e221-30
pubmed: 27126489
J Acquir Immune Defic Syndr. 2011 Jan 1;56(1):9-15
pubmed: 20921899
PLoS One. 2017 Aug 25;12(8):e0182384
pubmed: 28841646
Sci Rep. 2019 Jul 10;9(1):9997
pubmed: 31292462
PLoS One. 2013 Jul 09;8(7):e68076
pubmed: 23874501
J Microbiol. 2012 Oct;50(5):869-73
pubmed: 23124759
AIDS Patient Care STDS. 2007 Sep;21(9):702
pubmed: 17919097
AIDS Res Ther. 2020 Feb 7;17(1):5
pubmed: 32033571
Nucleic Acids Res. 2014 Oct;42(18):e144
pubmed: 25120265
Lancet HIV. 2020 Jun;7(6):e422-e433
pubmed: 32504575
J Infect Dis. 2007 Jul 15;196(2):328-9; author reply 329-30
pubmed: 17570122
J Exp Med. 1997 Feb 17;185(4):621-8
pubmed: 9034141
J Antimicrob Chemother. 2015 May;70(5):1391-5
pubmed: 25608585
Sci Rep. 2016 Apr 29;6:24883
pubmed: 27126912
Lancet Infect Dis. 2015 Mar;15(3):259-61
pubmed: 25749217
J Clin Microbiol. 2015 Aug;53(8):2581-92
pubmed: 26041893
J Antimicrob Chemother. 2011 Apr;66(4):890-5
pubmed: 21393136
J Virol. 2003 Jul;77(13):7682-8
pubmed: 12805470
J Acquir Immune Defic Syndr. 2011 Nov 1;58(3):233-40
pubmed: 21709569
BMC Bioinformatics. 2010 Oct 05;11:494
pubmed: 20923564
Infect Genet Evol. 2013 Oct;19:337-48
pubmed: 23660484
J Acquir Immune Defic Syndr. 2011 May 1;57(1):46-50
pubmed: 21346588