Adiposity impacts cognitive function in Asian populations: an epidemiological and Mendelian Randomization study.
Adiposity
Aging
Asia
Cardiovascular risk factors
Cognitive function
DEXA
General cognition
Mendelian Randomization
Metabolic syndrome
Visceral adiposity
Journal
The Lancet regional health. Western Pacific
ISSN: 2666-6065
Titre abrégé: Lancet Reg Health West Pac
Pays: England
ID NLM: 101774968
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
01
11
2022
revised:
19
01
2023
accepted:
26
01
2023
entrez:
28
2
2023
pubmed:
1
3
2023
medline:
1
3
2023
Statut:
epublish
Résumé
Obesity and related metabolic disturbances including diabetes, hypertension and hyperlipidemia predict future cognitive decline. Asia has a high prevalence of both obesity and metabolic disease, potentially amplifying the future burden of dementia in the region. We aimed to investigate the impact of adiposity and metabolic risk on cognitive function in Asian populations, using an epidemiological analysis and a two-sample Mendelian Randomization (MR) study. The Health for Life in Singapore (HELIOS) Study is a population-based cohort of South-East-Asian men and women in Singapore, aged 30-84 years. We analyzed 8769 participants with metabolic and cognitive data collected between 2018 and 2021. Whole-body fat mass was quantified with Dual X-Ray Absorptiometry (DEXA). Cognition was assessed using a computerized cognitive battery. An index of general cognition ' Participants were 58.9% female, and aged 51.4 (11.3) years. In univariate analysis, all 29 adiposity and metabolic measures assessed were associated with ' We show an independent relationship between adiposity and cognition in a multi-ethnic Asian population. MR analyses suggest that both visceral adiposity and raised BMI are likely to be causally linked to cognition. Our findings have important implications for preservation of cognitive health, including further motivation for action to reverse the rising burden of obesity in the Asia-Pacific region. The Nanyang Technological University-the Lee Kong Chian School of Medicine, National Healthcare Group, National Medical Research Council, Ministry of Education, Singapore.
Sections du résumé
Background
UNASSIGNED
Obesity and related metabolic disturbances including diabetes, hypertension and hyperlipidemia predict future cognitive decline. Asia has a high prevalence of both obesity and metabolic disease, potentially amplifying the future burden of dementia in the region. We aimed to investigate the impact of adiposity and metabolic risk on cognitive function in Asian populations, using an epidemiological analysis and a two-sample Mendelian Randomization (MR) study.
Methods
UNASSIGNED
The Health for Life in Singapore (HELIOS) Study is a population-based cohort of South-East-Asian men and women in Singapore, aged 30-84 years. We analyzed 8769 participants with metabolic and cognitive data collected between 2018 and 2021. Whole-body fat mass was quantified with Dual X-Ray Absorptiometry (DEXA). Cognition was assessed using a computerized cognitive battery. An index of general cognition '
Findings
UNASSIGNED
Participants were 58.9% female, and aged 51.4 (11.3) years. In univariate analysis, all 29 adiposity and metabolic measures assessed were associated with '
Interpretation
UNASSIGNED
We show an independent relationship between adiposity and cognition in a multi-ethnic Asian population. MR analyses suggest that both visceral adiposity and raised BMI are likely to be causally linked to cognition. Our findings have important implications for preservation of cognitive health, including further motivation for action to reverse the rising burden of obesity in the Asia-Pacific region.
Funding
UNASSIGNED
The Nanyang Technological University-the Lee Kong Chian School of Medicine, National Healthcare Group, National Medical Research Council, Ministry of Education, Singapore.
Identifiants
pubmed: 36851942
doi: 10.1016/j.lanwpc.2023.100710
pii: S2666-6065(23)00028-7
pmc: PMC9957736
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100710Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
J.C receives support for attending meetings and travel from Lee Kong Chian School of Medicine Strategic Academic Initiative and/or National Medical Research Council Singapore Translational Research Investigator Award and/or President's Chair in Cardiovascular Epidemiology. J.C. is Programme Director for Population and Global Health Programme at Lee Kong Chian School of Medicine, and Chief Scientific Officer at Precision Health Research, Singapore. J.N. receives research and educational grant from Astra Zeneca for cancer research unrelated to this work. All other authors declare no conflict of interest.
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