Effects of microtubule length and crowding on active microtubule network organization.
Biological sciences
Biophysics
Cell biology
Functional aspects of cell biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
17 Feb 2023
17 Feb 2023
Historique:
received:
23
09
2022
revised:
12
12
2022
accepted:
20
01
2023
entrez:
28
2
2023
pubmed:
1
3
2023
medline:
1
3
2023
Statut:
epublish
Résumé
Active filament networks can organize into various dynamic architectures driven by cross-linking motors. Densities and kinetic properties of motors and microtubules have been shown previously to determine active microtubule network self-organization, but the effects of other control parameters are less understood. Using computer simulations, we study here how microtubule lengths and crowding effects determine active network architecture and dynamics. We find that attractive interactions mimicking crowding effects or long microtubules both promote the formation of extensile nematic networks instead of asters. When microtubules are very long and the network is highly connected, a new isotropically motile network state resembling a "gliding mesh" is predicted. Using
Identifiants
pubmed: 36852161
doi: 10.1016/j.isci.2023.106063
pii: S2589-0042(23)00140-2
pmc: PMC9958361
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106063Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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