Cystathionine-γ-lyase overexpression modulates oxidized nicotinamide adenine dinucleotide biosynthesis and enhances neovascularization.
CGL
Endothelial cells
Hydrogen sulfide
Peripheral arterial disease
Journal
JVS-vascular science
ISSN: 2666-3503
Titre abrégé: JVS Vasc Sci
Pays: United States
ID NLM: 101767073
Informations de publication
Date de publication:
2023
2023
Historique:
received:
01
07
2022
accepted:
10
11
2022
entrez:
28
2
2023
pubmed:
1
3
2023
medline:
1
3
2023
Statut:
epublish
Résumé
Hydrogen sulfide is a proangiogenic gas produced primarily by the transsulfuration enzyme cystathionine-γ-lyase (CGL). CGL-dependent hydrogen sulfide production is required for neovascularization in models of peripheral arterial disease. However, the benefits of increasing endogenous CGL and its mechanism of action have not yet been elucidated. Male whole body CGL-overexpressing transgenic (CGL The restoration of blood flow occurred more rapidly in CGL Our results have demonstrated that CGL overexpression improves the neovascularization of skeletal muscle on hindlimb ischemia. These effects correlated with changes in the NAD pathway, which improved EC migration.
Identifiants
pubmed: 36852171
doi: 10.1016/j.jvssci.2022.11.003
pii: S2666-3503(22)00083-9
pmc: PMC9958478
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100095Informations de copyright
Copyright © 2023 by the Society for Vascular Surgery. Published by Elsevier Inc.
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