RND Pump-Mediated Efflux of Amotosalen, a Compound Used in Pathogen Inactivation Technology to Enhance Safety of Blood Transfusion Products, May Compromise Its Gram-Negative Anti-Bacterial Activity.

Membrane Transport Proteins / genetics Bacterial Proteins / genetics Escherichia coli / metabolism Furocoumarins / pharmacology Gram-Negative Bacteria Blood Transfusion Cell Division
Acinetobacter baumannii Eshcerichia coli Pseudomonas RND adeABC amotosalen antimicrobial resistance efflux mexXY multidrug resistance pathogen inactivation psoralen

Journal

mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533

Informations de publication

Date de publication:
20 04 2023
Historique:
medline: 24 4 2023
pubmed: 1 3 2023
entrez: 28 2 2023
Statut: ppublish

Résumé

Pathogen inactivation is a strategy to improve the safety of transfusion products. The only pathogen reduction technology for blood products currently approved in the US utilizes a psoralen compound, called amotosalen, in combination with UVA light to inactivate bacteria, viruses, and protozoa. Psoralens have structural similarity to bacterial multidrug efflux pump substrates. As these efflux pumps are often overexpressed in multidrug-resistant pathogens, we tested whether contemporary drug-resistant pathogens might show resistance to amotosalen and other psoralens based on multidrug efflux mechanisms through genetic, biophysical, and molecular modeling analysis. The main efflux systems in

Identifiants

DOI: 10.1128/msphere.00673-22 PMID: 36853056 PMC: PMC10117049
pubmed: 36853056
doi: 10.1128/msphere.00673-22
pmc: PMC10117049
doi:

Substances chimiques

amotosalen K1LDZ0VBC0
Membrane Transport Proteins 0
Bacterial Proteins 0
Furocoumarins 0

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0067322

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI145069
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI142040
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI146485
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007061
Pays : United States

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Auteurs

Alex B Green (AB)

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Lucius Chiaraviglio (L)

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Katherine A Truelson (KA)

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Katelyn E Zulauf (KE)

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Harvard Medical School, Boston, Massachusetts, USA.

Meng Cui (M)

Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts, USA.

Zhemin Zhang (Z)

Department of Pharmacology, Case Western Reserve University Medical Center, Cleveland, Ohio, USA.

Matthew P Ware (MP)

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Willy A Flegel (WA)

Department of Transfusion Medicine, NIH Clinical Center, National Institutes of Health Bethesda, Maryland, USA.
ORCID: 0000-0002-1631-7198

Richard L Haspel (RL)

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Harvard Medical School, Boston, Massachusetts, USA.

Edward W Yu (EW)

Department of Pharmacology, Case Western Reserve University Medical Center, Cleveland, Ohio, USA.

James E Kirby (JE)

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Harvard Medical School, Boston, Massachusetts, USA.
ORCID: 0000-0003-0392-4500

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › RND Pump-Mediated Efflux of Amotosalen, a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › RND Pump-Mediated Efflux of Amotosalen, a...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › RND Pump-Mediated Efflux of Amotosalen, a...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Furocoumarines › RND Pump-Mediated Efflux of Amotosalen, a...
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › RND Pump-Mediated Efflux of Amotosalen, a...
questionsmedicales.fr › Thérapeutique › Biothérapie › Transfusion sanguine › RND Pump-Mediated Efflux of Amotosalen, a...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Division cellulaire › RND Pump-Mediated Efflux of Amotosalen, a...