Isothiouronium-Mediated Conversion of Carboxylic Acids to Cyanomethyl Thioesters.
Journal
The Journal of organic chemistry
ISSN: 1520-6904
Titre abrégé: J Org Chem
Pays: United States
ID NLM: 2985193R
Informations de publication
Date de publication:
17 Mar 2023
17 Mar 2023
Historique:
pubmed:
1
3
2023
medline:
1
3
2023
entrez:
28
2
2023
Statut:
ppublish
Résumé
We report the development of an isothiouronium salt as a reagent for the operationally simple synthesis of cyanomethyl thioesters with high functional group tolerance and avoiding the use of thiols. Additionally, we show that the products can be engaged in amide synthesis in either a two-step or one-pot fashion.
Identifiants
pubmed: 36853206
doi: 10.1021/acs.joc.2c02902
pmc: PMC10028607
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3941-3944Références
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