Concurrent measurement of serum and radiomic biomarkers in the clinical investigation of equine musculoskeletal injuries: A prospective pilot study.
HDP
SPECT
fracture
geometric mean
Journal
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
ISSN: 1740-8261
Titre abrégé: Vet Radiol Ultrasound
Pays: England
ID NLM: 9209635
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
revised:
20
12
2022
received:
26
02
2022
accepted:
02
01
2023
medline:
2
6
2023
pubmed:
1
3
2023
entrez:
28
2
2023
Statut:
ppublish
Résumé
The prevention of musculoskeletal injuries and their related welfare and economic impacts represent an immediate priority for the horse racing industry. This prospective pilot study aimed to evaluate a method to quantitatively analyze scintigraphic features of specific anatomical regions of the horse's appendicular skeleton in combination with secondary measures of musculoskeletal metabolism in blood. Twelve horses referred for scintigraphic assessment of lameness were enrolled. Blood samples were collected immediately prior to the administration of radiotracer. Serum concentrations associated with bone turnover were determined for the following biomarkers: C-terminal telopeptides of type I collagen, proteoglycans and sulfated glycosaminoglycans, collagen type II, osteocalcin, and procollagen II C-terminal propeptide. Scintigraphic images underwent radiomic analysis of discrete regions of the distal limbs and these data were correlated to bone turnover markers. Three lame horses demonstrated asymmetrical radiomic abnormalities. The concentration of osteocalcin in the lame horses was significantly higher when compared to the control group, while no significant changes were observed for the other screened serum biomarkers. Findings from the current study provided evidence that radiomic analysis of equine scintigraphy is feasible. This method has the potential to interrogate which serum markers are associated with musculoskeletal injuries.
Substances chimiques
Osteocalcin
104982-03-8
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
484-491Subventions
Organisme : TeleMed Equine Research Program Fund
ID : EPBI2020
Informations de copyright
© 2023 American College of Veterinary Radiology.
Références
Thoroughbred Welfare Initiative. The Most Important Participant: A Framework for Thoroughbred Welfare. Report of the Thoroughbred Aftercare Welfare Working Group. Thoroughbred Aftercare Welfare Working Group 2021.
Plevin S, McLellan J. Clinical insights: musculoskeletal injury in the racehorse: what is new? Equine Vet J. 2020;52(5):639-642. doi:10.1111/evj.13309
Colgate VA, Group F, Marr CM. Science-in-brief: Risk assessment for reducing injuries of the fetlock bones in Thoroughbred racehorses. Equine Vet J. 2020;52(4):482-488. doi:10.1111/evj.13273
Parkin TD, Clegg PD, French NP, et al. Horse-level risk factors for fatal distal limb fracture in racing Thoroughbreds in the UK. Equine Vet J. 2004;36(6):513-519. doi:10.2746/0425164044877387
Frisbie DD, Mc Ilwraith CW, Arthur RM, Blea J, Baker VA, Billinghurst RC. Serum biomarker levels for musculoskeletal disease in two- and three-year-old racing Thoroughbred horses: A prospective study of 130 horses. Equine Vet J. 2010;42(7):643-651. doi:10.1111/j.2042-3306.2010.00123.x
McIlwraith CW, Clegg PD. Science in brief: Report on the Havemeyer Foundation workshop on equine musculoskeletal biomarkers - current knowledge and future needs. Equine Vet J. 2014;46(6):651-653. doi:10.1111/evj.12339
Turlo AJ, Cywinska A, Frisbie DD. Revisiting predictive biomarkers of musculoskeletal injury in thoroughbred racehorses: longitudinal study in polish population. BMC veterinary research. 2019;15(1):66. doi:10.1186/s12917-019-1799-7
Alwan WH, Carter SD, Bennett D, Edwards GB. Glycosaminoglycans in horses with osteoarthritis. Equine Vet J. 1991;23(1):44-47. doi:10.1111/j.2042-3306.1991.tb02712.x
Price JS. Biochemical markers of bone metabolism in horses: Potentials and limitations? Vet J. 1998;156(3):163-165. doi:10.1016/s1090-0233(98)80117-2
Jackson BF, Lonnell C, Verheyen KL, Dyson P, Pfeiffer DU, Price JS. Biochemical markers of bone metabolism and risk of dorsal metacarpal disease in 2-year-old Thoroughbreds. Equine Vet J. 2005;37(1):87-91. doi:10.2746/0425164054406775
Billinghurst RC, Brama PA, van Weeren PR, Knowlton MS, McIlwraith CW. Significant exercise-related changes in the serum levels of two biomarkers of collagen metabolism in young horses. Osteoarthr Cartil. 2003;11(10):760-769. doi:10.1016/s1063-4584(03)00152-3
Vial A, Stirling D, Field M, et al. The role of deep learning and radiomic feature extraction in cancer-specific predictive modelling: a review. Transl Cancer Res. 2018;7(3):803-816.
Currie G, Hawk KE, Rohren E, Vial A, Klein R. Machine learning and deep learning in medical imaging: intelligent imaging. J Med Imaging Radiat Sci. 2019;50(4):477-487. doi:10.1016/j.jmir.2019.09.005
Miller C, Filipow L, Jackson S. A review of activity quantification by planar imaging methods. J Nucl Med Technol. 1995;23(1):3-9.
IAEA. Quantitative Nuclear Medicine Imaging: Concepts, Requirements and Methods. International Atomic Energy Agency; 2014.
Nakajima K, Edenbrandt L, Mizokami A. Bone scan index: A new biomarker of bone metastasis in patients with prostate cancer. Int J Urol. 2017;24(9):668-673. doi:10.1111/iju.13386
Balon HR, Silberstein EB, Meier D. Society of Nuclear Medicine procedure guideline for thyroid uptake measurement. Thyroid. 2013;12:0.11.
Zadelhoff C, Ehrle A, Merle R, Jahn W, Lischer C. Thoracic processi spinosi findings agree among subjective, semiquantitative, and modified semiquantitative scintigraphic image evaluation methods and partially agree with clinical findings in horses with and without thoracolumbar pain. Vet Radiol Ultrasound. 2019;60(2):210-218. doi:10.1111/vru.12695
Valdés-Martínez A, Seiler G, Mai W, et al. Quantitative analysis of scintigraphic findings in tibial stress fractures in Thoroughbred racehorses. Am J Vet Res. 2008;69(7):886-890. doi:10.2460/ajvr.69.7.886
Parker RA, Bladon BM, Parkin TDH, Fraser BSL. Quantitative evaluation of subchondral bone injury of the plantaro-lateral condyles of the third metatarsal bone in Thoroughbred horses identified using nuclear scintigraphy: 48 cases: quantitative evaluation of subchondral bone injury in Thoroughbred horses. Equine Vet J. 2010;42(6):552-557. doi:10.1111/j.2042-3306.2010.00088.x
Weekes JS, Murray RC, Dyson SJ. Scintigraphic evaluation of metacarpophalangeal and metatarsophalangeal joints in clinically sound horses. Vet Radiol Ultrasound. 2004;45(1):85-90. doi:10.1111/j.1740-8261.2004.04014.x
Delmas PD, Malaval L, Arlot ME, Meunier PJ. Serum bone Gla-protein compared to bone histomorphometry in endocrine diseases. Bone. 1985;6(5):339-341. doi:10.1016/8756-3282(85)90326-6
Jackson BF, Goodship AE, Eastell R, Price JS. Evaluation of serum concentrations of biochemical markers of bone metabolism and insulin-like growth factor I associated with treadmill exercise in young horses. Am J Vet Res. 2003;64(12):1549-1556. doi:10.2460/ajvr.2003.64.1549
Jackson BF, Dyson PK, Lonnell C, Verheyen KLP, Pfeiffer DU, Price JS. Bone biomarkers and risk of fracture in two- and three-year-old Thoroughbreds. Equine Vet J. 2009;41(4):410-413.
Brown JP, Delmas PD, Malaval L, Edouard C, Chapuy MC, Meunier PJ. Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis. Lancet. 1984;1(8386):1091-1093. doi:10.1016/s0140-6736(84)92506-6