Vitamin D Metabolism Genes are Differentially Methylated in Individuals with Chronic Knee Pain.
Journal
Lifestyle genomics
ISSN: 2504-3188
Titre abrégé: Lifestyle Genom
Pays: Switzerland
ID NLM: 101716139
Informations de publication
Date de publication:
28 Feb 2023
28 Feb 2023
Historique:
received:
08
06
2022
accepted:
01
02
2023
pmc-release:
28
08
2024
entrez:
28
2
2023
pubmed:
1
3
2023
medline:
1
3
2023
Statut:
aheadofprint
Résumé
Recent evidence suggests that Vitamin D may interact with the epigenome and play a role in the pain experience. In order for proper functioning to occur, there must be an adequate level of Vitamin D present, made possible by enzymatic reactions that allow Vitamin D to be biologically active. The purpose of this study was to explore the epigenetic landscape of genes involved in Vitamin D metabolism in individuals with and without chronic knee pain. Community-dwelling individuals recruited as part of a larger study focused on knee pain provided demographic, clinical and pain-related information, as well as an intravenous blood sample to determine DNA methylation levels at CpG sites. There were differences in DNA methylation between those with and without pain in genes that code for enzymes related to Vitamin D metabolism: CYP24A1 (24-hydroxylase) and CYP27B1 (1--hydroxylase). There was also hypermethylation on the gene that codes for the Vitamin D receptor (VDR). The presence of chronic pain is associated with epigenetic modifications in genes responsible for the expression of enzymes involved in Vitamin D metabolism and cellular function. These results lay groundwork in understanding the mechanism underlying the association between Vitamin D and chronic pain.
Identifiants
pubmed: 36854277
pii: 000529823
doi: 10.1159/000529823
pmc: PMC10493864
mid: NIHMS1918513
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : R01 AG059809
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067757
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG033906
Pays : United States
Informations de copyright
The Author(s). Published by S. Karger AG, Basel.
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