Familial Primary Biliary Cholangitis With Different Clinical Courses Based on Anti-gp210 Antibody Positivity: A Report of Two Cases.
anti-glycoprotein 210 antibody
clinical course
familial onset
first-degree relatives
primary biliary cholangitis
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
accepted:
27
01
2023
entrez:
1
3
2023
pubmed:
2
3
2023
medline:
2
3
2023
Statut:
epublish
Résumé
A 30-year-old woman (daughter) was diagnosed to have primary biliary cholangitis (PBC) with autoimmune hepatitis (AIH) overlap syndrome. Although she was started on prednisolone and ursodeoxycholic acid (UA), she eventually died of hepatic failure with gastrointestinal hemorrhage seven months after the initial hospitalization. A 60-year-old woman (mother) was diagnosed with PBC with alcoholic liver cirrhosis, was treated with UA, and had no disease progression. These familial PBC patients had different clinical courses. While the mother was negative for the anti-glycoprotein 210 (anti-gp210) antibody, the daughter was positive for the same. These findings suggest that anti-gp210 antibody positivity affects the prognosis of PBC, even in familial cases.
Identifiants
pubmed: 36855497
doi: 10.7759/cureus.34275
pmc: PMC9968480
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e34275Informations de copyright
Copyright © 2023, Nagata et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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