Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected Parents.

Humans Child, Preschool Child Adolescent Young Adult Adult Psychotic Disorders / diagnosis Bipolar Disorder / diagnosis Schizophrenia / diagnosis Parents Risk Factors
Bipolar and Related Disorders Depressive Disorders Genetics/Genomics Major Depressive Disorder Schizophrenia Spectrum and Other Psychotic Disorders

Journal

The American journal of psychiatry
ISSN: 1535-7228
Titre abrégé: Am J Psychiatry
Pays: United States
ID NLM: 0370512

Informations de publication

Date de publication:
01 04 2023
Historique:
medline: 4 4 2023
pubmed: 2 3 2023
entrez: 1 3 2023
Statut: ppublish

Résumé

Family history is an established risk factor for mental illness. The authors sought to investigate whether polygenic scores (PGSs) can complement family history to improve identification of risk for major mood and psychotic disorders. Eight cohorts were combined to create a sample of 1,884 participants ages 2-36 years, including 1,339 offspring of parents with mood or psychotic disorders, who were prospectively assessed with diagnostic interviews over an average of 5.1 years. PGSs were constructed for depression, bipolar disorder, anxiety, attention deficit hyperactivity disorder (ADHD), schizophrenia, neuroticism, subjective well-being, There were 435 onsets of major mood and psychotic disorders across follow-up. PGSs for neuroticism (hazard ratio=1.23, 95% CI=1.12-1.36), schizophrenia (hazard ratio=1.15, 95% CI=1.04-1.26), depression (hazard ratio=1.11, 95% CI=1.01-1.22), ADHD (hazard ratio=1.10, 95% CI=1.00-1.21), subjective well-being (hazard ratio=0.90, 95% CI=0.82-0.99), and Neuroticism and subjective well-being PGSs capture risk of major mood and psychotic disorders that is independent of family history, whereas PGSs for psychiatric illness provide limited predictive power when family history is known. Neuroticism and subjective well-being PGSs may complement family history in the early identification of persons at elevated risk.

Identifiants

DOI: 10.1176/appi.ajp.20220476 PMID: 36856707
pubmed: 36856707
doi: 10.1176/appi.ajp.20220476
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

285-293

Subventions

Organisme : CIHR
Pays : Canada
Organisme : NIMH NIH HHS
ID : R01 MH073151
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH068006
Pays : United States
Organisme : Medical Research Council
ID : MR/R004609/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Auteurs

Alyson Zwicker (A)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Janice M Fullerton (JM)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Niamh Mullins (N)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Frances Rice (F)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Danella M Hafeman (DM)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Neeltje E M van Haren (NEM)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Nikita Setiaman (N)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

John A Merranko (JA)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Benjamin I Goldstein (BI)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Alessandra G Ferrera (AG)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Emma K Stapp (EK)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Elena de la Serna (E)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Dolores Moreno (D)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Gisela Sugranyes (G)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Sergio Mas Herrero (SM)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Gloria Roberts (G)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Claudio Toma (C)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Peter R Schofield (PR)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Howard J Edenberg (HJ)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Holly C Wilcox (HC)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Melvin G McInnis (MG)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Victoria Powell (V)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Lukas Propper (L)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Eileen Denovan-Wright (E)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Guy Rouleau (G)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Josefina Castro-Fornieles (J)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Manon H J Hillegers (MHJ)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Boris Birmaher (B)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Anita Thapar (A)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Philip B Mitchell (PB)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Cathryn M Lewis (CM)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Martin Alda (M)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

John I Nurnberger (JI)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

Rudolf Uher (R)

Department of Psychiatry (Zwicker, Propper, Denovan-Wright, Alda, Uher) and Department of Pharmacology (Denovan-Wright), Dalhousie University, Halifax, Nova Scotia, Canada; Nova Scotia Health, Halifax (Zwicker, Alda, Uher); Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada (Zwicker); Neuroscience Research Australia, Randwick, New South Wales, Australia (Fullerton, Toma, Schofield); School of Medical Sciences, University of New South Wales, Kensington, Australia (Fullerton, Toma, Schofield); Department of Genetics and Genomic Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Mullins); Wolfson Centre for Young People's Mental Health, Section of Child and Adolescent Psychiatry, Division of Psychological Medicine and Clinical Neurosciences, and MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, U.K. (Rice, Powell, Thapar); Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh (Hafeman, Merranko, Birmaher); Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands (van Haren, Setiaman, Hillegers); Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands (van Haren, Setiaman, Hillegers); Center for Addiction and Mental Health, University of Toronto Faculty of Medicine, Ontario (Goldstein); Department of Psychiatry (Ferrera, Nurnberger) and Stark Neurosciences Research Institute (Nurnberger), Indiana University School of Medicine, Indianapolis; NIMH, Bethesda, Md. (Stapp); Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain (de la Serna, Moreno, Sugranyes, Castro-Fornieles); Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic of Barcelona, Spain (de la Serna, Sugranyes, Castro-Fornieles); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Madrid (Moreno); Department of Psychiatry, Universitat de Barcelona, Spain (Herrero); School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia (Roberts, Mitchell); Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid/CSIC, Madrid (Toma); Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis (Edenberg); Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry and Public Health, Johns Hopkins Medicine, and Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Wilcox); Department of Psychiatry, University of Michigan, Ann Arbor (McInnis); IWK Health Centre, Halifax (Propper); Montreal Neurological Institute and Department of Neurology, McGill University, Montreal (Rouleau); Department of Medicine, University of Barcelona, Barcelona, Spain (Castro-Fornieles); Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Lewis).

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Classifications MeSH

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